Click here to switch to the map view.

The map label for this gene is hflC [H]

Identifier: 154245607

GI number: 154245607

Start: 1882384

End: 1883286

Strand: Reverse

Name: hflC [H]

Synonym: Xaut_1663

Alternate gene names: 154245607

Gene position: 1883286-1882384 (Counterclockwise)

Preceding gene: 154245608

Following gene: 154245606

Centisome position: 35.47

GC content: 68.11

Gene sequence:

>903_bases
ATGAGAAACCCGATCCTCGGCGGGGTCGTCGCCATTCTCGGCGTCGTTGCCCTCGTCCTCATCTATTCCGCGGCCTTCAT
CGTCCAGCAGACCCAGCAGGCGCTGGTGCTGCGGCTCGGCGAGCCGCTGGCCCCCGTGACCACGCCGGGACTGCACTGGA
AGGTGCCGTTCATCGACAGCGTGGTCTATATCGACAACCGGATCCTGGACCTGGAAAATCCCTCCCAGGAGGTGATCGCC
TCGGACCAGAAGCGGCTGGTGGTGGACGCATTCGCGCGCTACCGCATCACCGCCCCGCTGCGCTTCTTCCAGTCGGTGGG
GACGGTGCAGGGCGCCAACTCACGCCTCTCCACGGTGCTGAACTCCGCGCTGCGCCGGGTTCTGGGCGAGAACAGCTTCA
TCAGCCTGGTGCGTGACGGCCGCGAAGGCCTGATGCACCAGATCGCCGAGCAGGTGAACCGGGAGGCGGCGAACTTCGGC
ATCACCGTGGTGGATGTGCGCATCCGCCGCGCCGACCTGCCGGAGGCCAACAGCCAGGCGGTGTTCCAGCGCATGCAGAC
GGAACGCCAGCGCGAGGCCGCCGAGATCCGCGCCCAGGGCAATGAGGCCGCCCAGCGGCTGCGCGCCCGGGCCGATCGCG
AGGTAACCATCGTGGTGGCCGAGGCCAACTCGAAGGGCGAGCAGTTGCGCGGCGAGGGCGATGCGGAACGCAACCGCATC
TTCGCCGACGCGTTCGGGCGCGATCCGGACTTCTTCTCCTTCTACCGGTCCATGCAGGCCTATGAAGCCAGCATCAAGCC
CAGCGACACCCGGATGGTGCTGAGCCCGGATGCGCGCTTCTTCCGCTACTTCCAGGACCCCGTGAGCGCGGTGGCTCCCC
CCGCCCCCGCGGCCGGCAACTGA

Upstream 100 bases:

>100_bases
TATCCGCCGGCGGGCCGGGAGGCGTCGTGCCCGTGCTGCCGCTCAACGATCTCCTCCGCCGCCAGCCGGCGCCTGTCGCC
CAGCCCCAGGGAGCCACGCG

Downstream 100 bases:

>100_bases
ACAAGGGGCCGGGTGCGGCATGAAGGACCTGATCGCCGCGCTCGGCCTCATGCTGGCCATCGAAGGCTTGTGCCTCGCCG
CCTTTCCGGGGGCATGGCGC

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MRNPILGGVVAILGVVALVLIYSAAFIVQQTQQALVLRLGEPLAPVTTPGLHWKVPFIDSVVYIDNRILDLENPSQEVIA
SDQKRLVVDAFARYRITAPLRFFQSVGTVQGANSRLSTVLNSALRRVLGENSFISLVRDGREGLMHQIAEQVNREAANFG
ITVVDVRIRRADLPEANSQAVFQRMQTERQREAAEIRAQGNEAAQRLRARADREVTIVVAEANSKGEQLRGEGDAERNRI
FADAFGRDPDFFSFYRSMQAYEASIKPSDTRMVLSPDARFFRYFQDPVSAVAPPAPAAGN

Sequences:

>Translated_300_residues
MRNPILGGVVAILGVVALVLIYSAAFIVQQTQQALVLRLGEPLAPVTTPGLHWKVPFIDSVVYIDNRILDLENPSQEVIA
SDQKRLVVDAFARYRITAPLRFFQSVGTVQGANSRLSTVLNSALRRVLGENSFISLVRDGREGLMHQIAEQVNREAANFG
ITVVDVRIRRADLPEANSQAVFQRMQTERQREAAEIRAQGNEAAQRLRARADREVTIVVAEANSKGEQLRGEGDAERNRI
FADAFGRDPDFFSFYRSMQAYEASIKPSDTRMVLSPDARFFRYFQDPVSAVAPPAPAAGN
>Mature_300_residues
MRNPILGGVVAILGVVALVLIYSAAFIVQQTQQALVLRLGEPLAPVTTPGLHWKVPFIDSVVYIDNRILDLENPSQEVIA
SDQKRLVVDAFARYRITAPLRFFQSVGTVQGANSRLSTVLNSALRRVLGENSFISLVRDGREGLMHQIAEQVNREAANFG
ITVVDVRIRRADLPEANSQAVFQRMQTERQREAAEIRAQGNEAAQRLRARADREVTIVVAEANSKGEQLRGEGDAERNRI
FADAFGRDPDFFSFYRSMQAYEASIKPSDTRMVLSPDARFFRYFQDPVSAVAPPAPAAGN

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790617, Length=317, Percent_Identity=34.384858044164, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1786697, Length=285, Percent_Identity=24.9122807017544, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790616, Length=214, Percent_Identity=27.5700934579439, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=182, Percent_Identity=28.021978021978, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=183, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987621, Length=233, Percent_Identity=29.1845493562232, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25153583, Length=233, Percent_Identity=29.1845493562232, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17569497, Length=218, Percent_Identity=27.9816513761468, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71987612, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI32564147, Length=196, Percent_Identity=25, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566490, Length=205, Percent_Identity=28.2926829268293, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45556022, Length=235, Percent_Identity=28.936170212766, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI18860517, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33269; Mature: 33269

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNPILGGVVAILGVVALVLIYSAAFIVQQTQQALVLRLGEPLAPVTTPGLHWKVPFIDS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHE
VVYIDNRILDLENPSQEVIASDQKRLVVDAFARYRITAPLRFFQSVGTVQGANSRLSTVL
EEEECCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NSALRRVLGENSFISLVRDGREGLMHQIAEQVNREAANFGITVVDVRIRRADLPEANSQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCHHH
VFQRMQTERQREAAEIRAQGNEAAQRLRARADREVTIVVAEANSKGEQLRGEGDAERNRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCCHHHHEE
FADAFGRDPDFFSFYRSMQAYEASIKPSDTRMVLSPDARFFRYFQDPVSAVAPPAPAAGN
EHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRNPILGGVVAILGVVALVLIYSAAFIVQQTQQALVLRLGEPLAPVTTPGLHWKVPFIDS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHE
VVYIDNRILDLENPSQEVIASDQKRLVVDAFARYRITAPLRFFQSVGTVQGANSRLSTVL
EEEECCEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
NSALRRVLGENSFISLVRDGREGLMHQIAEQVNREAANFGITVVDVRIRRADLPEANSQA
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCHHH
VFQRMQTERQREAAEIRAQGNEAAQRLRARADREVTIVVAEANSKGEQLRGEGDAERNRI
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHCCCCCHHHHEE
FADAFGRDPDFFSFYRSMQAYEASIKPSDTRMVLSPDARFFRYFQDPVSAVAPPAPAAGN
EHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]