Click here to switch to the map view.

The map label for this gene is ccmE

Identifier: 154245600

GI number: 154245600

Start: 1875437

End: 1875916

Strand: Direct

Name: ccmE

Synonym: Xaut_1656

Alternate gene names: 154245600

Gene position: 1875437-1875916 (Clockwise)

Preceding gene: 154245599

Following gene: 154245601

Centisome position: 35.33

GC content: 70.42

Gene sequence:

>480_bases
ATGACGCGCAAAGGCCGGCGGCTGGTGCTCATCGGAGCAGGACTTGGCGTGCTCGCGCTGGCGGCGGGGCTCATCCTGTC
CGCGCTCAACGACACCATCGTGTTCTTCCGCTCGCCCACGGAAGTGGCCCAGCAGCAGGTGGCCCCCGGCGCACGCCTGC
GCCTCGGCGGGCTGGTGGAGACGGGCAGCGTGGTCAAGTCCGGTACCCTCACCACCTTCAAGGTCACCGATGGCAACGCC
ACGGTGAAGGTGGCCTATTCCGGCATCCTGCCGGACCTGTTCCGCGAAGGGCAGGGGGTGGTGGCCGAGGGCGCGCTCCA
GCCCGACGGCAGCTTCAAGGCCGACAGCGTGCTGGCCAAGCATGACGAGAAATACATGCCACGCGAGGTGGCCGACGCCC
TGAAGAAGCAGGGCCGCTGGCAGGAAGGCGGCCCGGCTCCCGGCACCGCCGCGCCGGTCCAGCGCGCGCCGGGGAGTTGA

Upstream 100 bases:

>100_bases
AAAAGGCACGTGCAGCCTTCAAGGACAATGCAGAAGCTCTCGGGCGGCTCGATGCCGCCGAGAAGGAGCTCGCGGCAAGG
ACGGGAGCGGGAGAAAAAGG

Downstream 100 bases:

>100_bases
GCCATGATCGCGGAAATCGGCCAGTACGCCCTCGCCCTCGCCTTCGCCCTCTCGCTGGCGCAGGTGCTGCTGCCGTCCTG
GGGCGCGCGGCGCAACGACC

Product: CcmE/CycJ protein

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTRKGRRLVLIGAGLGVLALAAGLILSALNDTIVFFRSPTEVAQQQVAPGARLRLGGLVETGSVVKSGTLTTFKVTDGNA
TVKVAYSGILPDLFREGQGVVAEGALQPDGSFKADSVLAKHDEKYMPREVADALKKQGRWQEGGPAPGTAAPVQRAPGS

Sequences:

>Translated_159_residues
MTRKGRRLVLIGAGLGVLALAAGLILSALNDTIVFFRSPTEVAQQQVAPGARLRLGGLVETGSVVKSGTLTTFKVTDGNA
TVKVAYSGILPDLFREGQGVVAEGALQPDGSFKADSVLAKHDEKYMPREVADALKKQGRWQEGGPAPGTAAPVQRAPGS
>Mature_158_residues
TRKGRRLVLIGAGLGVLALAAGLILSALNDTIVFFRSPTEVAQQQVAPGARLRLGGLVETGSVVKSGTLTTFKVTDGNAT
VKVAYSGILPDLFREGQGVVAEGALQPDGSFKADSVLAKHDEKYMPREVADALKKQGRWQEGGPAPGTAAPVQRAPGS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=145, Percent_Identity=44.8275862068966, Blast_Score=111, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_XANP2 (A7IFV8)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001416558.1
- ProteinModelPortal:   A7IFV8
- SMR:   A7IFV8
- STRING:   A7IFV8
- GeneID:   5424739
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_1656
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   ICFCSAC
- ProtClustDB:   CLSK979477
- BioCyc:   XAUT78245:XAUT_1656-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16508; Mature: 16377

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: NA

Important sites: BINDING 121-121

Signals:

None

Transmembrane regions:

HASH(0xff071dc)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKGRRLVLIGAGLGVLALAAGLILSALNDTIVFFRSPTEVAQQQVAPGARLRLGGLVE
CCCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCCEEEECCEEC
TGSVVKSGTLTTFKVTDGNATVKVAYSGILPDLFREGQGVVAEGALQPDGSFKADSVLAK
CCCEEECCCEEEEEEECCCEEEEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHH
HDEKYMPREVADALKKQGRWQEGGPAPGTAAPVQRAPGS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure 
TRKGRRLVLIGAGLGVLALAAGLILSALNDTIVFFRSPTEVAQQQVAPGARLRLGGLVE
CCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCCEEEECCEEC
TGSVVKSGTLTTFKVTDGNATVKVAYSGILPDLFREGQGVVAEGALQPDGSFKADSVLAK
CCCEEECCCEEEEEEECCCEEEEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHH
HDEKYMPREVADALKKQGRWQEGGPAPGTAAPVQRAPGS
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA