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The map label for this gene is gltR [H]

Identifier: 154245454

GI number: 154245454

Start: 1714876

End: 1715790

Strand: Reverse

Name: gltR [H]

Synonym: Xaut_1507

Alternate gene names: 154245454

Gene position: 1715790-1714876 (Counterclockwise)

Preceding gene: 154245455

Following gene: 154245453

Centisome position: 32.32

GC content: 65.79

Gene sequence:

>915_bases
ATGGTCGATTTCCGCAGCCTTGAAATCTTCTACTGGGTGTCGCAGCTGGAAAGCTTCAGCAAGGCGGCCGAGCGGCTGAA
CACCACCCAGCCCGCCGTATCCCAGCGCATCGCCGCGCTGGAGACCGAGTTGCGGACACGCCTGTTCGAGCGGTCCTCGC
GCTCCATCAGCCTCACCGAGAAGGGCCGGGTGCTGGTGGATTATGCCGAGCGCTTTCTCAGGCTGCGCTCCGCCATGCTG
GAAGCGGTGGCGACCCCCGAGGCCATGCGCGGGGTGGTGCGCCTCGGAGTTGCGGAGACCATCGTTCAGACTTGGCTGTC
CCGCTTCATCGAGCGGGCCCACGCGGTTTATCCGAACGTGCTCATCGACATCACGGTGGACGTGTCGCCGGTGATGCGCG
ACGCGCTGGTGAAGCGGGAGCTGGACCTCGCCTTCCTGCTGGGTCCGGTGAACGAGCCCAACATGAGCAACCTCGACCTC
GGCAGCTATGCGCTGGCCTTCATCGCCGCCAGCGACCTGTCCCTCGCGGCCGAGCCCCTGTCGCGGCGGGATCTTCTGAA
GTATCCGCTCATCACCTATCCGAAATCCACCTATCCCTATACTTTCCTGCGGGAGATCCTGAGCATTCCGGAGATCGGAT
CGCCGCGCCTGTTCAGCAATTCCTCCCTCTCCACCATCATCCGCATGACCGAGGACCATATCGGCCTCAGCGTCATTCCC
CCCGACGTGATCCGCGCGGAGCTGGCCGCCGGCAAGCTGCGGGTGGTTGAGACCGAGGTCGCCCTGCCGGACCTCGCCTT
CACCGCCAGCTATCCCATGGCCATGGGCGGCGGCATCGCCGGTCCGCTTGCCGCCCTCGCCGCAGAGGTGGCGCGGGAGG
ACCGGGCCGGGGAGTTGGCCAATAAGCGGGCATGA

Upstream 100 bases:

>100_bases
GTGGGCGGACGGGGGCAGATGGCGGCAGGGTGGAAGCCGCGATTGCCAGCGCCCCCCATCGGCCTACAATTGTGGCCCCT
CTTAAGGCGTACCGCGTTCG

Downstream 100 bases:

>100_bases
TTAAAGTTCATACAGGATCATAATTTGTATGCATGTATGGAGCGTGATGACATGGCGACCTCTCCCGCCGAGGCCCGACC
ATGCCATCTCAATCCGCACT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MVDFRSLEIFYWVSQLESFSKAAERLNTTQPAVSQRIAALETELRTRLFERSSRSISLTEKGRVLVDYAERFLRLRSAML
EAVATPEAMRGVVRLGVAETIVQTWLSRFIERAHAVYPNVLIDITVDVSPVMRDALVKRELDLAFLLGPVNEPNMSNLDL
GSYALAFIAASDLSLAAEPLSRRDLLKYPLITYPKSTYPYTFLREILSIPEIGSPRLFSNSSLSTIIRMTEDHIGLSVIP
PDVIRAELAAGKLRVVETEVALPDLAFTASYPMAMGGGIAGPLAALAAEVAREDRAGELANKRA

Sequences:

>Translated_304_residues
MVDFRSLEIFYWVSQLESFSKAAERLNTTQPAVSQRIAALETELRTRLFERSSRSISLTEKGRVLVDYAERFLRLRSAML
EAVATPEAMRGVVRLGVAETIVQTWLSRFIERAHAVYPNVLIDITVDVSPVMRDALVKRELDLAFLLGPVNEPNMSNLDL
GSYALAFIAASDLSLAAEPLSRRDLLKYPLITYPKSTYPYTFLREILSIPEIGSPRLFSNSSLSTIIRMTEDHIGLSVIP
PDVIRAELAAGKLRVVETEVALPDLAFTASYPMAMGGGIAGPLAALAAEVAREDRAGELANKRA
>Mature_304_residues
MVDFRSLEIFYWVSQLESFSKAAERLNTTQPAVSQRIAALETELRTRLFERSSRSISLTEKGRVLVDYAERFLRLRSAML
EAVATPEAMRGVVRLGVAETIVQTWLSRFIERAHAVYPNVLIDITVDVSPVMRDALVKRELDLAFLLGPVNEPNMSNLDL
GSYALAFIAASDLSLAAEPLSRRDLLKYPLITYPKSTYPYTFLREILSIPEIGSPRLFSNSSLSTIIRMTEDHIGLSVIP
PDVIRAELAAGKLRVVETEVALPDLAFTASYPMAMGGGIAGPLAALAAEVAREDRAGELANKRA

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=173, Percent_Identity=31.7919075144509, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790262, Length=247, Percent_Identity=26.7206477732794, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788297, Length=147, Percent_Identity=29.2517006802721, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=240, Percent_Identity=25, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082132, Length=254, Percent_Identity=24.8031496062992, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786401, Length=277, Percent_Identity=27.0758122743682, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789639, Length=261, Percent_Identity=24.5210727969349, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788626, Length=142, Percent_Identity=31.6901408450704, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787128, Length=218, Percent_Identity=27.0642201834862, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788748, Length=247, Percent_Identity=24.2914979757085, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081904, Length=206, Percent_Identity=26.6990291262136, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=267, Percent_Identity=25.8426966292135, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI2367136, Length=249, Percent_Identity=30.5220883534137, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786508, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1789173, Length=265, Percent_Identity=26.0377358490566, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1790399, Length=120, Percent_Identity=31.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=151, Percent_Identity=26.4900662251656, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI1786713, Length=210, Percent_Identity=30.952380952381, Blast_Score=61, Evalue=9e-11,
Organism=Escherichia coli, GI1790783, Length=272, Percent_Identity=25, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33570; Mature: 33570

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDFRSLEIFYWVSQLESFSKAAERLNTTQPAVSQRIAALETELRTRLFERSSRSISLTE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
KGRVLVDYAERFLRLRSAMLEAVATPEAMRGVVRLGVAETIVQTWLSRFIERAHAVYPNV
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LIDITVDVSPVMRDALVKRELDLAFLLGPVNEPNMSNLDLGSYALAFIAASDLSLAAEPL
EEEEEECCHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
SRRDLLKYPLITYPKSTYPYTFLREILSIPEIGSPRLFSNSSLSTIIRMTEDHIGLSVIP
HHHHHHHCCCEECCCCCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCEEECC
PDVIRAELAAGKLRVVETEVALPDLAFTASYPMAMGGGIAGPLAALAAEVAREDRAGELA
HHHHHHHHHCCCEEEEEHHHCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NKRA
CCCC
>Mature Secondary Structure
MVDFRSLEIFYWVSQLESFSKAAERLNTTQPAVSQRIAALETELRTRLFERSSRSISLTE
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
KGRVLVDYAERFLRLRSAMLEAVATPEAMRGVVRLGVAETIVQTWLSRFIERAHAVYPNV
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LIDITVDVSPVMRDALVKRELDLAFLLGPVNEPNMSNLDLGSYALAFIAASDLSLAAEPL
EEEEEECCHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
SRRDLLKYPLITYPKSTYPYTFLREILSIPEIGSPRLFSNSSLSTIIRMTEDHIGLSVIP
HHHHHHHCCCEECCCCCCCHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHCCCEEECC
PDVIRAELAAGKLRVVETEVALPDLAFTASYPMAMGGGIAGPLAALAAEVAREDRAGELA
HHHHHHHHHCCCEEEEEHHHCCCCHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHH
NKRA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]