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The map label for this gene is lpxK

Identifier: 154245428

GI number: 154245428

Start: 1690757

End: 1691788

Strand: Reverse

Name: lpxK

Synonym: Xaut_1481

Alternate gene names: 154245428

Gene position: 1691788-1690757 (Counterclockwise)

Preceding gene: 154245429

Following gene: 154245426

Centisome position: 31.87

GC content: 73.74

Gene sequence:

>1032_bases
ATGCGCGCGCCCGCCTTCTGGTGGCGCCGCCCGGGTGTTGCGAGTGCCCTGCTCTCCCCCATCGGCGCCGTGGTGGGCGC
CGTCGCGCTGGCCCGCATGGGCAAGGCCGGCGGGCGGGTGGACGCGCCGGTGCTGTGCATCGGAAATCCCACCGTGGGGG
GCGCGGGCAAAACGCCCACCGCCATCGCCCTCCTTGACCGCCTCACCGCCCGTGGCGCCACGCCCTTCGCCCTGCTGCGG
GGCCATGGCGGCTCGGCGCCGATGCCGTTGCGGGTGGATCCGGCGATCCACGGCGCCGACGCGGTGGGTGACGAGGCCCT
GCTGCTCGCCCGCCACGCCCCCACCATCGTCGCCGGCGGCGCGCGGCTGGCCGGTGCCGCGATGGCGGTTGAGACGGGTG
CGAGCCATATCGTCATGGACGACGGCTTCCAGAATCCGTCCCTGCACAAGGATGTGTCGGTTCTGGTGGTGGATGGAATG
GTGGGCGTCGGCAACGCCTGCGTCACCCCCGCCGGCCCGCTGCGAGCGCCGCTCCTGCCCCAACTGGCCCGCGCCGATGC
GGTGCTGGTGGTGGGCGACGGCAGCGCGGGGGACAGGGTGGCGGCCGAGGCCACTCAGGCGGGATGCACCGTGCTGCGCG
GCTGGCTGGTGCCCGATCCGGCGGCCGTGGCGGCGTTACACGGAATACCTCTCATCGCCTTCGCCGGCATCGGCCGGCCG
GAAAAATTCTTCGCGACGCTGGAAAGAGAAGGGCTGGCCCTGCTGGCACGCCACGCCTTCGCCGACCACCATCCGTTCCG
CCCCGCCGAAATCGCCCGGCTCGTCGAAGCCGCGCGGGCGCAGGGCGCACGGCTGGTGACCACGGAAAAGGACCGGGCAC
GCCTGACCGGCCCGGCCTTCGCTGGGCCGGAGTTCTCAGGTGTCCTCGACGCCATCGCGCCCCTGCCGGTCACCCTCGCC
CTCGACGCGCCGCACGCGCTCGACGCCCTTGTGGACCGCGCCGAAGCCCGCTTTCAAGCCCGGCGCACGTAG

Upstream 100 bases:

>100_bases
CAGCCTTCGCCACGGTCACGGGGCTGGGTGGCGCGTTGGATCGCACCCTCTCGGCCATCGAGCCCTATCTCATCCAGATC
CGCCTCGAGGCCCGCTGAGG

Downstream 100 bases:

>100_bases
AAGGCGAAGAGGCTCAGGCCCGGCGCGCGACGAGGGCGCTGGCCCCGACCGTCAGCCAGCCAAGGATCATCAGCGAGCCG
CCGAAAGGCGCGCTGCCGCC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAPAFWWRRPGVASALLSPIGAVVGAVALARMGKAGGRVDAPVLCIGNPTVGGAGKTPTAIALLDRLTARGATPFALLR
GHGGSAPMPLRVDPAIHGADAVGDEALLLARHAPTIVAGGARLAGAAMAVETGASHIVMDDGFQNPSLHKDVSVLVVDGM
VGVGNACVTPAGPLRAPLLPQLARADAVLVVGDGSAGDRVAAEATQAGCTVLRGWLVPDPAAVAALHGIPLIAFAGIGRP
EKFFATLEREGLALLARHAFADHHPFRPAEIARLVEAARAQGARLVTTEKDRARLTGPAFAGPEFSGVLDAIAPLPVTLA
LDAPHALDALVDRAEARFQARRT

Sequences:

>Translated_343_residues
MRAPAFWWRRPGVASALLSPIGAVVGAVALARMGKAGGRVDAPVLCIGNPTVGGAGKTPTAIALLDRLTARGATPFALLR
GHGGSAPMPLRVDPAIHGADAVGDEALLLARHAPTIVAGGARLAGAAMAVETGASHIVMDDGFQNPSLHKDVSVLVVDGM
VGVGNACVTPAGPLRAPLLPQLARADAVLVVGDGSAGDRVAAEATQAGCTVLRGWLVPDPAAVAALHGIPLIAFAGIGRP
EKFFATLEREGLALLARHAFADHHPFRPAEIARLVEAARAQGARLVTTEKDRARLTGPAFAGPEFSGVLDAIAPLPVTLA
LDAPHALDALVDRAEARFQARRT
>Mature_343_residues
MRAPAFWWRRPGVASALLSPIGAVVGAVALARMGKAGGRVDAPVLCIGNPTVGGAGKTPTAIALLDRLTARGATPFALLR
GHGGSAPMPLRVDPAIHGADAVGDEALLLARHAPTIVAGGARLAGAAMAVETGASHIVMDDGFQNPSLHKDVSVLVVDGM
VGVGNACVTPAGPLRAPLLPQLARADAVLVVGDGSAGDRVAAEATQAGCTVLRGWLVPDPAAVAALHGIPLIAFAGIGRP
EKFFATLEREGLALLARHAFADHHPFRPAEIARLVEAARAQGARLVTTEKDRARLTGPAFAGPEFSGVLDAIAPLPVTLA
LDAPHALDALVDRAEARFQARRT

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=312, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_XANP2 (A7IFD6)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001416386.1
- STRING:   A7IFD6
- GeneID:   5422036
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_1481
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   DEPVLIH
- ProtClustDB:   PRK00652
- BioCyc:   XAUT78245:XAUT_1481-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34966; Mature: 34966

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPAFWWRRPGVASALLSPIGAVVGAVALARMGKAGGRVDAPVLCIGNPTVGGAGKTPT
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCH
AIALLDRLTARGATPFALLRGHGGSAPMPLRVDPAIHGADAVGDEALLLARHAPTIVAGG
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEECC
ARLAGAAMAVETGASHIVMDDGFQNPSLHKDVSVLVVDGMVGVGNACVTPAGPLRAPLLP
CHHHHHHHEEECCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHH
QLARADAVLVVGDGSAGDRVAAEATQAGCTVLRGWLVPDPAAVAALHGIPLIAFAGIGRP
HHHCCCEEEEEECCCCCCHHHHHHHHHCHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCH
EKFFATLEREGLALLARHAFADHHPFRPAEIARLVEAARAQGARLVTTEKDRARLTGPAF
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCC
AGPEFSGVLDAIAPLPVTLALDAPHALDALVDRAEARFQARRT
CCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRAPAFWWRRPGVASALLSPIGAVVGAVALARMGKAGGRVDAPVLCIGNPTVGGAGKTPT
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCH
AIALLDRLTARGATPFALLRGHGGSAPMPLRVDPAIHGADAVGDEALLLARHAPTIVAGG
HHHHHHHHHHCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCCEEEEEECCCEEEECC
ARLAGAAMAVETGASHIVMDDGFQNPSLHKDVSVLVVDGMVGVGNACVTPAGPLRAPLLP
CHHHHHHHEEECCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHH
QLARADAVLVVGDGSAGDRVAAEATQAGCTVLRGWLVPDPAAVAALHGIPLIAFAGIGRP
HHHCCCEEEEEECCCCCCHHHHHHHHHCHHHHHCCCCCCHHHHHHHHCCCEEEEECCCCH
EKFFATLEREGLALLARHAFADHHPFRPAEIARLVEAARAQGARLVTTEKDRARLTGPAF
HHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCEECCCCC
AGPEFSGVLDAIAPLPVTLALDAPHALDALVDRAEARFQARRT
CCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA