Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 154245362

GI number: 154245362

Start: 1618568

End: 1619908

Strand: Reverse

Name: pyrC [H]

Synonym: Xaut_1415

Alternate gene names: 154245362

Gene position: 1619908-1618568 (Counterclockwise)

Preceding gene: 154245368

Following gene: 154245359

Centisome position: 30.51

GC content: 70.1

Gene sequence:

>1341_bases
ATGCCCGTGACTTTCGATCTGCTGCTCAAGGGCGGCGCGGTCGCGACCCCCGCCGGCATTGCCGTTGCGGACATCGGAGT
GACAGGCGGACGCATCCGCGCCATCGGCTCGCTGGCCGCCGCAAGCGCGGGTGAGGTGGTGGACGCCACCGGCCTCCACA
TCCTGCCCGGCGTCATCGACACCCAGGTGCATTTCCGCGAGCCGGGGCTGGAGCAGAAGGAAGACCTGGAGACCGGGTCG
CTGGCCGCCGTCATGGGCGGGGTGACCGGCGTGTTCGAGATGCCGAACACCATTCCCCAGACCACGACCGCCTCGGTGCT
GGAAGACAAGATCGCGCGCGGGACCAACCGCATGCACTGCGACTTCGCCTTCTACGTGGGCGGCACCCATGACAACGTGA
AGGACCTGCCCGAGCTGGAGCGCCTGCCCGGCGCTGCGGGCGTGAAGGTGTTCATCGGTTCGTCCACCGGCTCACTGCTG
GTGGCGGACGATGACGGGGTGCGCAACATCCTGAAAGTCATCCGCCGCCGCGCGGCCTTTCATTGCGAGGACGAGCCGCG
CCTCCAGGAGCGCAAGAGCCTGCGCGTGCCCGGGGATGCCTCCTCCCACCCGGTGTGGCGCGATGAGATCGCGGCGCTGA
CCGCCACCCGGCGCCTCGTCAACCTGGCCCGCGAGACCGGCGCGCGGGTGCATGTGCTGCACGTGACCTCGGCGGAGGAG
ATGGAATTCCTGGCCGATGCCCGCGACGTGGCCTCGGTGGAGGTGACGCCCCATCACCTCACCCTGGCGGCGCCGGACTG
CTACGAGCGGCTCGGCACGCTGGTGCAGATGAATCCTCCGGTGCGCGACGGCCGCCATCGCGATGCCCTGTGGGCGGCGC
TCCAGAGCGGCGTGGTGGACGTGCTCGGCTCCGACCACGCGCCCCACACGCTGGAGGAAAAGGCAAAGCCCTATCCCGAA
AGCCCCTCGGGCATGACCGGGGTGCAGACCCTGGTGCCGCTGATGCTGGACCATGTGGCCGCTGGGCGGCTGACGCTGGA
GCGCTTCGTGGACCTGTCCAGCGCCGGCCCCGCCCGGCTGTTCGGCATTGCCCGCAAGGGCCGCATCGTGGTGGGCTATG
ACGCCGACTTCACCGTGGTGGACCTGAAGCGCCGCGCCACCATCACGGCGGACTGGATCGCCTCGCGCTCCAAGTGGACG
CCCTATGACGGCAAGGAAGTCACCGGCTGGCCCGTGGGCACGTTCGTGCGCGGCCGCAAGGTGATGTGGGAAGGCGAGCT
CACCGGCCCCGCCTCCGGCGCGCCCATCGGCTTCCTGGAGACGCTCCAGCCGCAGGGCTGA

Upstream 100 bases:

>100_bases
CGGTCAAATAAACGACGGGCATGGGGGCCGTCCTTGTCAGAAAAATAAAAACCAGATTTAAGGCCGCTTGCCTGTCCCCA
TCAAGAGCGAGCTTCCTCCC

Downstream 100 bases:

>100_bases
GCCAAGGCGGTCCCCAAGCGGATTGCCAACGAAAGAGGGCGCGCCACCGGCGCGCCCTTTCTTTTCGGCGACAGGACTTG
CTTTCGACCGCTGGCAGCCC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGSLAAASAGEVVDATGLHILPGVIDTQVHFREPGLEQKEDLETGS
LAAVMGGVTGVFEMPNTIPQTTTASVLEDKIARGTNRMHCDFAFYVGGTHDNVKDLPELERLPGAAGVKVFIGSSTGSLL
VADDDGVRNILKVIRRRAAFHCEDEPRLQERKSLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEE
MEFLADARDVASVEVTPHHLTLAAPDCYERLGTLVQMNPPVRDGRHRDALWAALQSGVVDVLGSDHAPHTLEEKAKPYPE
SPSGMTGVQTLVPLMLDHVAAGRLTLERFVDLSSAGPARLFGIARKGRIVVGYDADFTVVDLKRRATITADWIASRSKWT
PYDGKEVTGWPVGTFVRGRKVMWEGELTGPASGAPIGFLETLQPQG

Sequences:

>Translated_446_residues
MPVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGSLAAASAGEVVDATGLHILPGVIDTQVHFREPGLEQKEDLETGS
LAAVMGGVTGVFEMPNTIPQTTTASVLEDKIARGTNRMHCDFAFYVGGTHDNVKDLPELERLPGAAGVKVFIGSSTGSLL
VADDDGVRNILKVIRRRAAFHCEDEPRLQERKSLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEE
MEFLADARDVASVEVTPHHLTLAAPDCYERLGTLVQMNPPVRDGRHRDALWAALQSGVVDVLGSDHAPHTLEEKAKPYPE
SPSGMTGVQTLVPLMLDHVAAGRLTLERFVDLSSAGPARLFGIARKGRIVVGYDADFTVVDLKRRATITADWIASRSKWT
PYDGKEVTGWPVGTFVRGRKVMWEGELTGPASGAPIGFLETLQPQG
>Mature_445_residues
PVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGSLAAASAGEVVDATGLHILPGVIDTQVHFREPGLEQKEDLETGSL
AAVMGGVTGVFEMPNTIPQTTTASVLEDKIARGTNRMHCDFAFYVGGTHDNVKDLPELERLPGAAGVKVFIGSSTGSLLV
ADDDGVRNILKVIRRRAAFHCEDEPRLQERKSLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEEM
EFLADARDVASVEVTPHHLTLAAPDCYERLGTLVQMNPPVRDGRHRDALWAALQSGVVDVLGSDHAPHTLEEKAKPYPES
PSGMTGVQTLVPLMLDHVAAGRLTLERFVDLSSAGPARLFGIARKGRIVVGYDADFTVVDLKRRATITADWIASRSKWTP
YDGKEVTGWPVGTFVRGRKVMWEGELTGPASGAPIGFLETLQPQG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=419, Percent_Identity=31.5035799522673, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI19923821, Length=444, Percent_Identity=27.9279279279279, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4503379, Length=443, Percent_Identity=25.0564334085779, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4503051, Length=446, Percent_Identity=25.3363228699552, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI190194363, Length=451, Percent_Identity=26.3858093126386, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4503377, Length=446, Percent_Identity=25.5605381165919, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI62422571, Length=446, Percent_Identity=25.3363228699552, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI4503375, Length=449, Percent_Identity=28.7305122494432, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1786722, Length=462, Percent_Identity=32.4675324675325, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=26.3982102908277, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193204318, Length=390, Percent_Identity=28.4615384615385, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17539558, Length=447, Percent_Identity=26.8456375838926, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71989490, Length=466, Percent_Identity=26.6094420600858, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI86575075, Length=464, Percent_Identity=25.4310344827586, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=390, Percent_Identity=30.5128205128205, Blast_Score=136, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=32.3907455012853, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI18859883, Length=432, Percent_Identity=27.3148148148148, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47763; Mature: 47632

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGSLAAASAGEVVDATGLHILPGVID
CCEEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEECCCCEEECCHHC
TQVHFREPGLEQKEDLETGSLAAVMGGVTGVFEMPNTIPQTTTASVLEDKIARGTNRMHC
CEEEECCCCCCCHHCCCCCCHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEE
DFAFYVGGTHDNVKDLPELERLPGAAGVKVFIGSSTGSLLVADDDGVRNILKVIRRRAAF
EEEEEECCCCCCHHHCHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHC
HCEDEPRLQERKSLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEE
CCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MEFLADARDVASVEVTPHHLTLAAPDCYERLGTLVQMNPPVRDGRHRDALWAALQSGVVD
HHHHHHHHHCEEEEECCCEEEEECCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCHHE
VLGSDHAPHTLEEKAKPYPESPSGMTGVQTLVPLMLDHVAAGRLTLERFVDLSSAGPARL
ECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHE
FGIARKGRIVVGYDADFTVVDLKRRATITADWIASRSKWTPYDGKEVTGWPVGTFVRGRK
EEEECCCEEEEEECCCEEEEEECCCCEEEHHHHCCCCCCCCCCCCEECCCCCHHEECCCE
VMWEGELTGPASGAPIGFLETLQPQG
EEEECCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
PVTFDLLLKGGAVATPAGIAVADIGVTGGRIRAIGSLAAASAGEVVDATGLHILPGVID
CEEEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEECCCCEEECCHHC
TQVHFREPGLEQKEDLETGSLAAVMGGVTGVFEMPNTIPQTTTASVLEDKIARGTNRMHC
CEEEECCCCCCCHHCCCCCCHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCEEE
DFAFYVGGTHDNVKDLPELERLPGAAGVKVFIGSSTGSLLVADDDGVRNILKVIRRRAAF
EEEEEECCCCCCHHHCHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHC
HCEDEPRLQERKSLRVPGDASSHPVWRDEIAALTATRRLVNLARETGARVHVLHVTSAEE
CCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MEFLADARDVASVEVTPHHLTLAAPDCYERLGTLVQMNPPVRDGRHRDALWAALQSGVVD
HHHHHHHHHCEEEEECCCEEEEECCHHHHHHCCEEECCCCCCCCCCHHHHHHHHHHCHHE
VLGSDHAPHTLEEKAKPYPESPSGMTGVQTLVPLMLDHVAAGRLTLERFVDLSSAGPARL
ECCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHE
FGIARKGRIVVGYDADFTVVDLKRRATITADWIASRSKWTPYDGKEVTGWPVGTFVRGRK
EEEECCCEEEEEECCCEEEEEECCCCEEEHHHHCCCCCCCCCCCCEECCCCCHHEECCCE
VMWEGELTGPASGAPIGFLETLQPQG
EEEECCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA