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The map label for this gene is purE [H]

Identifier: 154245204

GI number: 154245204

Start: 1445993

End: 1446475

Strand: Reverse

Name: purE [H]

Synonym: Xaut_1256

Alternate gene names: 154245204

Gene position: 1446475-1445993 (Counterclockwise)

Preceding gene: 154245205

Following gene: 154245203

Centisome position: 27.25

GC content: 71.22

Gene sequence:

>483_bases
ATGAGCACGGCTGACGTTGCCGTCATCATGGGCAGCCAGTCCGATTGGGAAACCATGCGCCACGCGTCCGAGACGCTGGA
AGCGCTGAAGATCCCGCACGACAGCCGCATCGTCTCCGCCCATCGCACGCCCGAGCGCATGTACGCCTTCGCCCGCAGCG
CGAAGGCGGACGGCTTCAAGGTGATCATCGCCGGCGCCGGCGGGGCGGCCCACCTGCCGGGCATGGTGGCGGCGCTCACC
ACCCTGCCCGTGTTCGGCGTGCCGGTGCAGTCCAAGGCCCTGTCCGGCCTCGACAGCCTCTATTCCATCGTCCAGATGCC
GGCCGGCGTTCCGGTAGGGACGCTGGCCATCGGCGTCGCCGGAGCGACCAATGCGGCGCTGCTGGCGGCTTCCGTGCTGG
CGCTCTCGGACCCGGCCCTGTCGCAACGCCTCGAAGCCTGGCGGGCATCCCGCACCGCGGCGGTGGCGGAACGGCCGGCC
TGA

Upstream 100 bases:

>100_bases
CACCCGCGCCCGGATGCGGACAGGAGAGTTGGCCGCAACCCTTGCCCCCGCTGCGGCGATCCTATAAAGCCGCGCTTTCC
GTTTTAAGGGGTCTTGAGGG

Downstream 100 bases:

>100_bases
GCCATGCTGAAACCCGGAAGCGTCATCGGCATCCTCGGCGGCGGCCAGCTCGGCCGCATGATCGCGCTCGCTGCGGCGGA
GCTGGGCCTGAAGACCCATA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSTADVAVIMGSQSDWETMRHASETLEALKIPHDSRIVSAHRTPERMYAFARSAKADGFKVIIAGAGGAAHLPGMVAALT
TLPVFGVPVQSKALSGLDSLYSIVQMPAGVPVGTLAIGVAGATNAALLAASVLALSDPALSQRLEAWRASRTAAVAERPA

Sequences:

>Translated_160_residues
MSTADVAVIMGSQSDWETMRHASETLEALKIPHDSRIVSAHRTPERMYAFARSAKADGFKVIIAGAGGAAHLPGMVAALT
TLPVFGVPVQSKALSGLDSLYSIVQMPAGVPVGTLAIGVAGATNAALLAASVLALSDPALSQRLEAWRASRTAAVAERPA
>Mature_159_residues
STADVAVIMGSQSDWETMRHASETLEALKIPHDSRIVSAHRTPERMYAFARSAKADGFKVIIAGAGGAAHLPGMVAALTT
LPVFGVPVQSKALSGLDSLYSIVQMPAGVPVGTLAIGVAGATNAALLAASVLALSDPALSQRLEAWRASRTAAVAERPA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=63.9240506329114, Blast_Score=181, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324702, Length=142, Percent_Identity=56.3380281690141, Blast_Score=148, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16431; Mature: 16300

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTADVAVIMGSQSDWETMRHASETLEALKIPHDSRIVSAHRTPERMYAFARSAKADGFK
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCEE
VIIAGAGGAAHLPGMVAALTTLPVFGVPVQSKALSGLDSLYSIVQMPAGVPVGTLAIGVA
EEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
GATNAALLAASVLALSDPALSQRLEAWRASRTAAVAERPA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STADVAVIMGSQSDWETMRHASETLEALKIPHDSRIVSAHRTPERMYAFARSAKADGFK
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCCCCEE
VIIAGAGGAAHLPGMVAALTTLPVFGVPVQSKALSGLDSLYSIVQMPAGVPVGTLAIGVA
EEEEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCC
GATNAALLAASVLALSDPALSQRLEAWRASRTAAVAERPA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]