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The map label for this gene is purK [H]

Identifier: 154245203

GI number: 154245203

Start: 1444880

End: 1445989

Strand: Reverse

Name: purK [H]

Synonym: Xaut_1255

Alternate gene names: 154245203

Gene position: 1445989-1444880 (Counterclockwise)

Preceding gene: 154245204

Following gene: 154245202

Centisome position: 27.24

GC content: 70.81

Gene sequence:

>1110_bases
ATGCTGAAACCCGGAAGCGTCATCGGCATCCTCGGCGGCGGCCAGCTCGGCCGCATGATCGCGCTCGCTGCGGCGGAGCT
GGGCCTGAAGACCCATATCCTGTGCCCCGACAAGGATAGCCCCGCCTTCCATGTGAGCGAACACCACATCTGCGCGCCCT
ACGACGACTTCGCGGCGCTGGAGCGCTTCGCGGCCGGCGTGGACGTGGTGACCTACGAATTCGAGAACGTGCCGCTGGCC
ACCGCCGAGTTCCTCGCCGCCCGGGTGCCCCTGAGGCCGGGCGCGAAGGCCCTCGCCATCACCCAGGACCGACTGGCGGA
AAAGAGCTTCGTGCGCGACCTCGGCATCGAGACCGCGCCGTTCGCCGCCGTGGACGACCTCGCCGGCCTTGAGGCGGGCG
TGGCGGCGCTTGGCCTGCCGGCGGTGCTGAAGACCCGGCGCTTCGGGTATGACGGCAAGGGCCAGGTCATCATCCGCCCG
GAGGAAGACCTCACCGCCGCCTGGCACGCCCTGGGCCGGCAGAGCGCGATCCTGGAGGGCTTCGTCGCCTTCGAGCGCGA
GGTCTCGGTGGTGGCGGCGCGGCGGGCCGATGGCGCCTTCCAGGCCTTCGACGTGACCGAGAACGTGCATCGCGAGCACA
TCCTGCACACCTCCACCGTGCCCGCCACCCTGTCGGCCGGCGCGGCGCGCCAGGCCCGGTCCATCGCCCGCGCCATCGGC
GATGCCCTCGACTATGAGGGGGTGTTCGCGGTGGAATTGTTCGTGGTGGGATGCGGCGCGGACGAACGGGTGATCGTCAA
CGAGATCGCCCCGCGCGTGCACAACAGCGGGCACTGGACCCAGGACGGCGCCGTGACCTCCCAGTTCGAGCAGCATGTGC
GCGCCATCGCCGGCTGGCCGCTGGGCGAGGTGGCGCGCATCGGCCGGGTTGAGATGACCAACCTCATCGGCGCCGACGTG
CATGACTGGCATGCGCTGCTCGCCGAGCCCGGCGCCCACGTCCATCTCTACGGCAAGGACGAGGCCCGCGCCGGCCGCAA
GATGGGCCACGTGGTGCGGGTGCGCCGCGATCCGGAAGCCTGCACCAACATTCCGGAAGCCGGCTGCTAG

Upstream 100 bases:

>100_bases
GGCTTCCGTGCTGGCGCTCTCGGACCCGGCCCTGTCGCAACGCCTCGAAGCCTGGCGGGCATCCCGCACCGCGGCGGTGG
CGGAACGGCCGGCCTGAGCC

Downstream 100 bases:

>100_bases
AACACTGTTCCCGCCCCTCGGCAGGACTGTCCCAGAGCTGTCACAGCCGTGCCATCGAGCCTGACCAAAATACCGCCTGA
AGCTTGACCTTCCGCGACCT

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MLKPGSVIGILGGGQLGRMIALAAAELGLKTHILCPDKDSPAFHVSEHHICAPYDDFAALERFAAGVDVVTYEFENVPLA
TAEFLAARVPLRPGAKALAITQDRLAEKSFVRDLGIETAPFAAVDDLAGLEAGVAALGLPAVLKTRRFGYDGKGQVIIRP
EEDLTAAWHALGRQSAILEGFVAFEREVSVVAARRADGAFQAFDVTENVHREHILHTSTVPATLSAGAARQARSIARAIG
DALDYEGVFAVELFVVGCGADERVIVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGEVARIGRVEMTNLIGADV
HDWHALLAEPGAHVHLYGKDEARAGRKMGHVVRVRRDPEACTNIPEAGC

Sequences:

>Translated_369_residues
MLKPGSVIGILGGGQLGRMIALAAAELGLKTHILCPDKDSPAFHVSEHHICAPYDDFAALERFAAGVDVVTYEFENVPLA
TAEFLAARVPLRPGAKALAITQDRLAEKSFVRDLGIETAPFAAVDDLAGLEAGVAALGLPAVLKTRRFGYDGKGQVIIRP
EEDLTAAWHALGRQSAILEGFVAFEREVSVVAARRADGAFQAFDVTENVHREHILHTSTVPATLSAGAARQARSIARAIG
DALDYEGVFAVELFVVGCGADERVIVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGEVARIGRVEMTNLIGADV
HDWHALLAEPGAHVHLYGKDEARAGRKMGHVVRVRRDPEACTNIPEAGC
>Mature_369_residues
MLKPGSVIGILGGGQLGRMIALAAAELGLKTHILCPDKDSPAFHVSEHHICAPYDDFAALERFAAGVDVVTYEFENVPLA
TAEFLAARVPLRPGAKALAITQDRLAEKSFVRDLGIETAPFAAVDDLAGLEAGVAALGLPAVLKTRRFGYDGKGQVIIRP
EEDLTAAWHALGRQSAILEGFVAFEREVSVVAARRADGAFQAFDVTENVHREHILHTSTVPATLSAGAARQARSIARAIG
DALDYEGVFAVELFVVGCGADERVIVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWPLGEVARIGRVEMTNLIGADV
HDWHALLAEPGAHVHLYGKDEARAGRKMGHVVRVRRDPEACTNIPEAGC

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=361, Percent_Identity=36.01108033241, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1788155, Length=373, Percent_Identity=28.9544235924933, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=363, Percent_Identity=33.3333333333333, Blast_Score=191, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39479; Mature: 39479

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKPGSVIGILGGGQLGRMIALAAAELGLKTHILCPDKDSPAFHVSEHHICAPYDDFAAL
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCEECCCHHHHHH
ERFAAGVDVVTYEFENVPLATAEFLAARVPLRPGAKALAITQDRLAEKSFVRDLGIETAP
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCC
FAAVDDLAGLEAGVAALGLPAVLKTRRFGYDGKGQVIIRPEEDLTAAWHALGRQSAILEG
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHH
FVAFEREVSVVAARRADGAFQAFDVTENVHREHILHTSTVPATLSAGAARQARSIARAIG
HHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHH
DALDYEGVFAVELFVVGCGADERVIVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWP
HHCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
LGEVARIGRVEMTNLIGADVHDWHALLAEPGAHVHLYGKDEARAGRKMGHVVRVRRDPEA
HHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCEEEEECCCHH
CTNIPEAGC
HCCCCCCCC
>Mature Secondary Structure
MLKPGSVIGILGGGQLGRMIALAAAELGLKTHILCPDKDSPAFHVSEHHICAPYDDFAAL
CCCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEECCCCEECCCHHHHHH
ERFAAGVDVVTYEFENVPLATAEFLAARVPLRPGAKALAITQDRLAEKSFVRDLGIETAP
HHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCC
FAAVDDLAGLEAGVAALGLPAVLKTRRFGYDGKGQVIIRPEEDLTAAWHALGRQSAILEG
CHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHH
FVAFEREVSVVAARRADGAFQAFDVTENVHREHILHTSTVPATLSAGAARQARSIARAIG
HHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHH
DALDYEGVFAVELFVVGCGADERVIVNEIAPRVHNSGHWTQDGAVTSQFEQHVRAIAGWP
HHCCCCCEEEEEEEEEECCCCCEEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCC
LGEVARIGRVEMTNLIGADVHDWHALLAEPGAHVHLYGKDEARAGRKMGHVVRVRRDPEA
HHHHHHCCCHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHCCEEEEECCCHH
CTNIPEAGC
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]