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The map label for this gene is murC

Identifier: 154245140

GI number: 154245140

Start: 1371449

End: 1372861

Strand: Direct

Name: murC

Synonym: Xaut_1192

Alternate gene names: 154245140

Gene position: 1371449-1372861 (Clockwise)

Preceding gene: 154245139

Following gene: 154245144

Centisome position: 25.83

GC content: 67.02

Gene sequence:

>1413_bases
ATGAAGTTGCCGTCCGGCCTCGGCTCCATCCATTTCGTCGGCATCGGCGGCATCGGCATGAGCGGCATCGCCGAAGTGCT
GCACAATCTCGGCTATGAGGTGCAGGGCTCGGACGTGGCGGACAGCGCCAACGTGAAGCGCCTGCGCGACCTCGGCATCA
AGGTGATGATCGGCCACTCCGCGGTCAATGTGGATGACGCCGACGTGGTGGTGGTCTCCTCCGCCATCAAGCGCGACAAT
CCGGAGCTGGTGGCCGCCCGCACCAAGCGCCTGCCGGTGGTGCGCCGCGCCGAGATGCTGGCCGAACTGATGCGGCTGAA
GAGCTGCGTCTCCATCGCCGGCACCCACGGCAAGACCACCACCACCTCCATGGTGGCGGCACTGCTGGACGCCGGCAATT
TCGACCCCACCGTCATCAACGGCGGCATCATCAACGCCTACGGCACCAATGCCCGCCTCGGCGACGGCAACTGGATGGTG
GTGGAAGCGGACGAGAGCGACGGCACCTTCCTGAAACTGCCCACGGAAGTCGCCATCGTCACCAATGTGGACCCCGAGCA
CCTCGACCATTTCAAGACCTTCGACAAGGTGCAGGACGCCTTCAAGACCTTCGTGGAGAACGTGCCCTTCTACGGCTTCG
CGGTGATGTGCATCGACCATCCGGTGGTGCAGGCGCTGGTGGGCCGCATCGAGGACCGGCGCGTCATCACCTATGGCGAG
AACCCGCAGGCGGACGTGCGCCTCGTGGACGTGGACCTGAAGGGCGGCATCACCCGCTTCGGCGTCGTCTTCCGCAACCG
CGCGGGGGAGACGGTGCACGAGATTTCCGGGCTCAAGCTGCCCATGCCGGGCAAGCACAATGCGCTCAACGCCACTGCGG
CCATCGCGGTGGCCCATGAGCTGAAGGTGCCCGACGACAAGATCATCGAGGCCATCGCCAATTTCGGTGGCGTGAAGCGG
CGTTTCACCCGCACCGGGGAATGGAACGGCGTCACCGTGTTCGACGACTACGGCCACCACCCGGTGGAGATCGCCGCCGT
GCTGAAGGCGGCGCGGGCGGCGAGTGAGGGGCAGGTGATCGCCGTGGTGCAGCCGCACCGCTATTCGCGGCTCGCCTCCC
TGTTCGACGAATTCTGCACCTGCTTCAACGATGCCGACCACGTGGTGGTGGCCCCGGTCTATGCCGCCGGCGAGACCCCC
ATCGAGGGCGCGGACCGGGACCATCTGGTGCAGGGCCTCATCGCCCACGGCCACCGCTCGGTGACGGCGCTGGAGGGACC
GGAACGGCTTGCCCAGGTGGTGGGTGGGCTGGCGAAGCCGGGAGACTACGTCATCTGCCTCGGCGCCGGCTCCATCAGCG
GCTGGGCCTATGCCCTGCCGGGGGAACTGGCCGCGCTCAAGCCGGCGGCTTAG

Upstream 100 bases:

>100_bases
CCAGAAGCCAGGGTGTGCTCGACGCAGCGGAACGACTGGGCGATCTCGTCCGGCATCTGGCGGCGAAGGGCGCGGTCGCA
ACCTTTCAGGGGAAACTGGC

Downstream 100 bases:

>100_bases
GGGGCGGCGGGCAGGAGGTAACCGGCGTGCAGGCAGCGGGGAGCGCCTCGGCGCCTGCCGTCGAAAGCTTGTAGATATCC
CCGACTGCGACGAACATGAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHSAVNVDDADVVVVSSAIKRDN
PELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTTTTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMV
VEADESDGTFLKLPTEVAIVTNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGE
NPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHELKVPDDKIIEAIANFGGVKR
RFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVIAVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETP
IEGADRDHLVQGLIAHGHRSVTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA

Sequences:

>Translated_470_residues
MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHSAVNVDDADVVVVSSAIKRDN
PELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTTTTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMV
VEADESDGTFLKLPTEVAIVTNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGE
NPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHELKVPDDKIIEAIANFGGVKR
RFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVIAVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETP
IEGADRDHLVQGLIAHGHRSVTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA
>Mature_470_residues
MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHSAVNVDDADVVVVSSAIKRDN
PELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTTTTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMV
VEADESDGTFLKLPTEVAIVTNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGE
NPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHELKVPDDKIIEAIANFGGVKR
RFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVIAVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETP
IEGADRDHLVQGLIAHGHRSVTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=44.2516268980477, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1790680, Length=465, Percent_Identity=28.8172043010753, Blast_Score=160, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_XANP2 (A7IEJ8)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001416098.1
- ProteinModelPortal:   A7IEJ8
- SMR:   A7IEJ8
- STRING:   A7IEJ8
- GeneID:   5422631
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_1192
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   XAUT78245:XAUT_1192-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50112; Mature: 50112

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCEEEEECCC
AVNVDDADVVVVSSAIKRDNPELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTT
EECCCCCCEEEEEHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
TTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMVVEADESDGTFLKLPTEVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEECCCEEEEE
TNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECC
NPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHE
CCCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHHEEEEEHH
LKVPDDKIIEAIANFGGVKRRFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVI
CCCCHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
AVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETPIEGADRDHLVQGLIAHGHRS
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC
VTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA
EEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKLPSGLGSIHFVGIGGIGMSGIAEVLHNLGYEVQGSDVADSANVKRLRDLGIKVMIGHS
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHCCEEEEECCC
AVNVDDADVVVVSSAIKRDNPELVAARTKRLPVVRRAEMLAELMRLKSCVSIAGTHGKTT
EECCCCCCEEEEEHHHCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCH
TTSMVAALLDAGNFDPTVINGGIINAYGTNARLGDGNWMVVEADESDGTFLKLPTEVAIV
HHHHHHHHHHCCCCCCEEEECCEEEECCCCCEECCCCEEEEEECCCCCCEEECCCEEEEE
TNVDPEHLDHFKTFDKVQDAFKTFVENVPFYGFAVMCIDHPVVQALVGRIEDRRVITYGE
ECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCCCCCCEEEEECC
NPQADVRLVDVDLKGGITRFGVVFRNRAGETVHEISGLKLPMPGKHNALNATAAIAVAHE
CCCCCEEEEEEECCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCHHHEEEEEHH
LKVPDDKIIEAIANFGGVKRRFTRTGEWNGVTVFDDYGHHPVEIAAVLKAARAASEGQVI
CCCCHHHHHHHHHHCCCHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEE
AVVQPHRYSRLASLFDEFCTCFNDADHVVVAPVYAAGETPIEGADRDHLVQGLIAHGHRS
EEECCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCC
VTALEGPERLAQVVGGLAKPGDYVICLGAGSISGWAYALPGELAALKPAA
EEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA