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The map label for this gene is nadC [H]

Identifier: 154245129

GI number: 154245129

Start: 1357622

End: 1358473

Strand: Reverse

Name: nadC [H]

Synonym: Xaut_1181

Alternate gene names: 154245129

Gene position: 1358473-1357622 (Counterclockwise)

Preceding gene: 154245130

Following gene: 154245127

Centisome position: 25.59

GC content: 72.65

Gene sequence:

>852_bases
ATGCCCCTCGACCCGCTCCCCGAGCTGATGGTGGAGCCCATCGTGCGCGCCGCGCTGCTGGAGGATCTCGGCCGGGCCGG
CGACATCACCACCGACGCAGTGGTGCCCCCCGGCCATGAGAGCCGCCTCGTGCTCGCCGCGCGCCAGCCCGGCGTGGTGG
CAGGCCTCGATTGCGCCCGCCTCGCCTTCCGTCTGCTGGATGGCGCCGTGCGCTTCACCCCGCGCGTGACGGACGGCGCC
GCCGTGGAGCCCGGCACGGTGCTGGCGCAGGTGGAGGGCTCGTCCCGCGCTCTGCTCACCGGCGAGCGCACCGGGCTGAA
CCTCGCCTGCCGGCTCTCCGGCATCGCCACCGCAACAGCGGGGCTGGTTGCCGCCATCGCCGGCCACAAGGCGCAGATCG
TCTGCACCCGCAAGACCACGCCGGGGCTGCGGTCGCTGGAAAAATACGCGGTGCGCGCCGGCGGCGGCGCCAACCATCGC
TTCGGCCTCGATGATGCGGTGCTCATCAAGGACAACCATGTGGCCATCGCCGGCTCGGTGCGCGAGGCTATGAGCCGGGT
GCGGGCGCGGGCCGGCCACATGGTGAAGGTGGAGGTGGAGGTGGACACCCTCGCCCAGCTGGAAGAGCTGCTCACCATCG
GCGCCGACGCGGTGCTGCTCGACAACATGACGCCTGAGACACTCACCGAGGCCGTGCGCATGGTGGGCGGGCGCATGCTC
ACCGAGGCCTCCGGCCGGGTGAACCGCGATACCGCGCCGGCCATCGCGGCGGCGGGCGTGGACCTCATCTCCGTGGGCTG
GCTGACCCACAGCGCCCCCATCCTCGACATCGGCCTCGACTGGGTGGGGTGA

Upstream 100 bases:

>100_bases
CCCGGCGCTCCCGCACCACCCTTGAGCGCACCCTGGCCGAGGCCCGCCGCCATGCCGCGCCGGCCTTCGCCCTCGCCTCA
TCCAGCTGACGGATCGTTCC

Downstream 100 bases:

>100_bases
GCGCGCCCCAAACGAAAACGGCCGGGCGAGAGCCCGGCCGTTCCGTATCAACAGGCTGAGAAAACCCTCAGGCCATCACT
TTCACGCCGCCTTGGGCCAG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPLDPLPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCARLAFRLLDGAVRFTPRVTDGA
AVEPGTVLAQVEGSSRALLTGERTGLNLACRLSGIATATAGLVAAIAGHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHR
FGLDDAVLIKDNHVAIAGSVREAMSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRML
TEASGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGLDWVG

Sequences:

>Translated_283_residues
MPLDPLPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCARLAFRLLDGAVRFTPRVTDGA
AVEPGTVLAQVEGSSRALLTGERTGLNLACRLSGIATATAGLVAAIAGHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHR
FGLDDAVLIKDNHVAIAGSVREAMSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRML
TEASGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGLDWVG
>Mature_282_residues
PLDPLPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCARLAFRLLDGAVRFTPRVTDGAA
VEPGTVLAQVEGSSRALLTGERTGLNLACRLSGIATATAGLVAAIAGHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHRF
GLDDAVLIKDNHVAIAGSVREAMSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRMLT
EASGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGLDWVG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=37.410071942446, Blast_Score=148, Evalue=6e-36,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=43.3333333333333, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=249, Percent_Identity=33.3333333333333, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29472; Mature: 29341

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDPLPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCAR
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHH
LAFRLLDGAVRFTPRVTDGAAVEPGTVLAQVEGSSRALLTGERTGLNLACRLSGIATATA
HHHHHHHCHHEECCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHH
GLVAAIAGHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHRFGLDDAVLIKDNHVAIAGSV
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEHHH
REAMSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRML
HHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCEEE
TEASGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGLDWVG
ECCCCCCCCCCCCHHHHCCCHHEEECHHHCCCCEEEECCCCCC
>Mature Secondary Structure 
PLDPLPELMVEPIVRAALLEDLGRAGDITTDAVVPPGHESRLVLAARQPGVVAGLDCAR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCHHHH
LAFRLLDGAVRFTPRVTDGAAVEPGTVLAQVEGSSRALLTGERTGLNLACRLSGIATATA
HHHHHHHCHHEECCCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEEEECCHHHHHH
GLVAAIAGHKAQIVCTRKTTPGLRSLEKYAVRAGGGANHRFGLDDAVLIKDNHVAIAGSV
HHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEHHH
REAMSRVRARAGHMVKVEVEVDTLAQLEELLTIGADAVLLDNMTPETLTEAVRMVGGRML
HHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHCCEEE
TEASGRVNRDTAPAIAAAGVDLISVGWLTHSAPILDIGLDWVG
ECCCCCCCCCCCCHHHHCCCHHEEECHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]