Click here to switch to the map view.

The map label for this gene is ilvD [H]

Identifier: 154244972

GI number: 154244972

Start: 1173764

End: 1175566

Strand: Reverse

Name: ilvD [H]

Synonym: Xaut_1022

Alternate gene names: 154244972

Gene position: 1175566-1173764 (Counterclockwise)

Preceding gene: 154244973

Following gene: 154244971

Centisome position: 22.14

GC content: 69.11

Gene sequence:

>1803_bases
ATGAGCGACGAGACCAAGGGCAAGCCCGTGCAAGTCATGCCCGTCCAAGACACGCCCGGCGCCAAGGAAGCCGCCAAGCA
AAGCACCAAGCCCCTGCGCAGCCAGGCCTGGTTCGGCCGGCAGGACAAGATGGGCTTCTATTACCGGTCCTTCCTGAAGA
ACTCCGGCTTCCCCCAGGACCAGTTCGACGGCCGCCCGGTCATCGGCATCTGTAACACCTGGTCGGAGCTGACCCCCTGC
AACGCCCATTTCCGCACCATCGCCGAGCATGTGCGCTACGGGGTGCTGGATGCCGGTGGCTTCCCGCTGGAATTCCCGGT
CTCCTCCCTTGGCGAGGTGACCATGCGGCCCACCGCCATGCTGTTCCGCAACCTCGCCTCCATGGACGTGGAGGAGGCCA
TCCGCGCCCATCCCCTCGACGGCGTGGTGCTGCTGATGGGCTGCGACAAGACCACCCCCGCCCTGCTCATGGGCGCGGCC
TCCGCCGACCTGCCGGCCATCGGCGTGTCCGGCGGGCCGCAGTTGCGTGGCGTCTATCGCGGCGAGATCATCGGCTCGGG
CACCAACATCATCTCCATGAGCGAGCAGTTGCGCGCCGGGGAGATCACCCTTGCCGACTTCCACGAGGCGGAGGCGGCCA
TGAACCGCTCCGCCGGCAGTTGCATGACCATGGGCACGGCTTCGACGATGGCCTCGATGGTCGAGGCCCTTGGCCTCGGC
CTGCCGGAGAATGCCGCCATCCCCGCCGCCGACGCCCGGCGCAACCTGCTCGCCCGCATGGCCGGCCGGCGCATCGTCGA
GATGGCGAAGGCGGACCTGAAGCCCTCCGACATCCTCACCCGCGCGGCCTTCGAGAACGCCATCCGGGCGCTGGCGGCCA
TCGGCGGTTCCACCAATGCGGTGGTGCACCTGCTCGCCATCGCCGGCCGGGTGGGCGTGGAGCTGACCCTGGAGGATTTC
GACCGGCTGGGCCGCGACGTGCACTGCCTGGTGGACCTCATGCCCTCCGGCCGCTTCCTGATGGAGGATTTCTACTATGC
CGGCGGCCTGCCCGCCGTGCTGCGCACGCTCGGCGAGCGCGGGCTCCTGAACCGCGAGGCGCTGACCGTCAACGGCCGCT
CCATCTGGGAGAATGTGGCCGAGGCGCCGTGCTGGAATGAGGAGGTCATCACCCCGTTCGAGGCGCCGTTCAAGGCCGAC
GCCGGCATTGCCATCCTGAAGGGCAACCTTGCCCCGGACGGCGCCGTGATCAAGCCCTCGGCGGCCTCTCCCGAGCTGAT
GCAGCACACCGGCCGCGCCGTGGTGTTCGAGAGCGTGGAGGAGATGCACCACGCCGTGAACGACGAGGCCCTCGACATCG
ACGCCTCCTCAATCATGGTGCTGAAGCATTGTGGGCCCAAGGGCTATCCCGGCATGGCGGAGGTGGGCAACATGCCCCTG
CCCGCCAAACTGCTACGCCAGGGCGTACGCGACATGATCCGCATCTCGGATGCCCGCATGTCCGGCACCGCCTATGGCAC
GGTGGTGCTGCACGTGGCGCCCGAGGCCACGGCCGGAGGCCCGCTGGCCCTGGTGAAGACCGGCGACCTCATCACCCTCG
ACGTGCCCGCCCGTGCCCTGCACCTCCACGTGAGCGAAGAGGAGCTCGCGGCCCGCCGCGCCGCCTGGGTGCCGCCCGCT
CCCCACGCCGAGCGCGGCTATCAGCGCCTCTACATCGACCACGTGCTGCAGGCCGACCGCGGCGCGGATTTCGATTTTCT
CGTCGGCCGCACCGGATCGCCGGTGCCGCGCGACAATCACTGA

Upstream 100 bases:

>100_bases
GGCCAGGGAGGACAGCCGCAGTGTCACGCAAAGACCCGCCGCGCGCCGATGATCCTGGCCTTGCCACGCCGCGCCGCAAC
GGCATGACGGGACACGCAGC

Downstream 100 bases:

>100_bases
AGGTGACCCATGCCCACGTTTCCTGCCGCGCGCCCGTTCAAGGGCGTGTTCCCGGTGGCGCCCACCGTGTTCGACGCCGC
CGGCGCGCTTGATCTGGACG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 600; Mature: 599

Protein sequence:

>600_residues
MSDETKGKPVQVMPVQDTPGAKEAAKQSTKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPC
NAHFRTIAEHVRYGVLDAGGFPLEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAA
SADLPAIGVSGGPQLRGVYRGEIIGSGTNIISMSEQLRAGEITLADFHEAEAAMNRSAGSCMTMGTASTMASMVEALGLG
LPENAAIPAADARRNLLARMAGRRIVEMAKADLKPSDILTRAAFENAIRALAAIGGSTNAVVHLLAIAGRVGVELTLEDF
DRLGRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGERGLLNREALTVNGRSIWENVAEAPCWNEEVITPFEAPFKAD
AGIAILKGNLAPDGAVIKPSAASPELMQHTGRAVVFESVEEMHHAVNDEALDIDASSIMVLKHCGPKGYPGMAEVGNMPL
PAKLLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATAGGPLALVKTGDLITLDVPARALHLHVSEEELAARRAAWVPPA
PHAERGYQRLYIDHVLQADRGADFDFLVGRTGSPVPRDNH

Sequences:

>Translated_600_residues
MSDETKGKPVQVMPVQDTPGAKEAAKQSTKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPC
NAHFRTIAEHVRYGVLDAGGFPLEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAA
SADLPAIGVSGGPQLRGVYRGEIIGSGTNIISMSEQLRAGEITLADFHEAEAAMNRSAGSCMTMGTASTMASMVEALGLG
LPENAAIPAADARRNLLARMAGRRIVEMAKADLKPSDILTRAAFENAIRALAAIGGSTNAVVHLLAIAGRVGVELTLEDF
DRLGRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGERGLLNREALTVNGRSIWENVAEAPCWNEEVITPFEAPFKAD
AGIAILKGNLAPDGAVIKPSAASPELMQHTGRAVVFESVEEMHHAVNDEALDIDASSIMVLKHCGPKGYPGMAEVGNMPL
PAKLLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATAGGPLALVKTGDLITLDVPARALHLHVSEEELAARRAAWVPPA
PHAERGYQRLYIDHVLQADRGADFDFLVGRTGSPVPRDNH
>Mature_599_residues
SDETKGKPVQVMPVQDTPGAKEAAKQSTKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQDQFDGRPVIGICNTWSELTPCN
AHFRTIAEHVRYGVLDAGGFPLEFPVSSLGEVTMRPTAMLFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAAS
ADLPAIGVSGGPQLRGVYRGEIIGSGTNIISMSEQLRAGEITLADFHEAEAAMNRSAGSCMTMGTASTMASMVEALGLGL
PENAAIPAADARRNLLARMAGRRIVEMAKADLKPSDILTRAAFENAIRALAAIGGSTNAVVHLLAIAGRVGVELTLEDFD
RLGRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGERGLLNREALTVNGRSIWENVAEAPCWNEEVITPFEAPFKADA
GIAILKGNLAPDGAVIKPSAASPELMQHTGRAVVFESVEEMHHAVNDEALDIDASSIMVLKHCGPKGYPGMAEVGNMPLP
AKLLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATAGGPLALVKTGDLITLDVPARALHLHVSEEELAARRAAWVPPAP
HAERGYQRLYIDHVLQADRGADFDFLVGRTGSPVPRDNH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=597, Percent_Identity=31.4907872696817, Blast_Score=266, Evalue=4e-72,
Organism=Escherichia coli, GI2367371, Length=471, Percent_Identity=31.8471337579618, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1788157, Length=516, Percent_Identity=31.0077519379845, Blast_Score=180, Evalue=3e-46,
Organism=Escherichia coli, GI1786464, Length=445, Percent_Identity=32.8089887640449, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=552, Percent_Identity=32.0652173913043, Blast_Score=271, Evalue=2e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64325; Mature: 64193

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDETKGKPVQVMPVQDTPGAKEAAKQSTKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQD
CCCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
QFDGRPVIGICNTWSELTPCNAHFRTIAEHVRYGVLDAGGFPLEFPVSSLGEVTMRPTAM
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCHHHHCCCCCCHHHH
LFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADLPAIGVSGGPQLRGVYR
HHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCCEEECCCCCCCCEEEE
GEIIGSGTNIISMSEQLRAGEITLADFHEAEAAMNRSAGSCMTMGTASTMASMVEALGLG
CEEEECCCCEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCC
LPENAAIPAADARRNLLARMAGRRIVEMAKADLKPSDILTRAAFENAIRALAAIGGSTNA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
VVHLLAIAGRVGVELTLEDFDRLGRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGER
HHHHHHHHCCCCEEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHC
GLLNREALTVNGRSIWENVAEAPCWNEEVITPFEAPFKADAGIAILKGNLAPDGAVIKPS
CCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCC
AASPELMQHTGRAVVFESVEEMHHAVNDEALDIDASSIMVLKHCGPKGYPGMAEVGNMPL
CCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCHHHHCCCCC
PAKLLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATAGGPLALVKTGDLITLDVPARAL
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCEEE
HLHVSEEELAARRAAWVPPAPHAERGYQRLYIDHVLQADRGADFDFLVGRTGSPVPRDNH
EEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SDETKGKPVQVMPVQDTPGAKEAAKQSTKPLRSQAWFGRQDKMGFYYRSFLKNSGFPQD
CCCCCCCCEEEEECCCCCCHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
QFDGRPVIGICNTWSELTPCNAHFRTIAEHVRYGVLDAGGFPLEFPVSSLGEVTMRPTAM
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCCCHHHHCCCCCCHHHH
LFRNLASMDVEEAIRAHPLDGVVLLMGCDKTTPALLMGAASADLPAIGVSGGPQLRGVYR
HHHHHHHCCHHHHHHHCCCCCEEEEEECCCCCHHHEEECCCCCCCEEECCCCCCCCEEEE
GEIIGSGTNIISMSEQLRAGEITLADFHEAEAAMNRSAGSCMTMGTASTMASMVEALGLG
CEEEECCCCEEEHHHHHCCCCEEEHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCC
LPENAAIPAADARRNLLARMAGRRIVEMAKADLKPSDILTRAAFENAIRALAAIGGSTNA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
VVHLLAIAGRVGVELTLEDFDRLGRDVHCLVDLMPSGRFLMEDFYYAGGLPAVLRTLGER
HHHHHHHHCCCCEEEEHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHC
GLLNREALTVNGRSIWENVAEAPCWNEEVITPFEAPFKADAGIAILKGNLAPDGAVIKPS
CCCCCCEEEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEECCC
AASPELMQHTGRAVVFESVEEMHHAVNDEALDIDASSIMVLKHCGPKGYPGMAEVGNMPL
CCCCHHHHHCCCCHHHHHHHHHHHHCCCCCEECCCCCEEEEEECCCCCCCCHHHHCCCCC
PAKLLRQGVRDMIRISDARMSGTAYGTVVLHVAPEATAGGPLALVKTGDLITLDVPARAL
CHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEECCCEEEEECCCEEE
HLHVSEEELAARRAAWVPPAPHAERGYQRLYIDHVLQADRGADFDFLVGRTGSPVPRDNH
EEEECHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA