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The map label for this gene is edd [H]

Identifier: 154244968

GI number: 154244968

Start: 1168975

End: 1170834

Strand: Direct

Name: edd [H]

Synonym: Xaut_1018

Alternate gene names: 154244968

Gene position: 1168975-1170834 (Clockwise)

Preceding gene: 154244967

Following gene: 154244969

Centisome position: 22.02

GC content: 70.59

Gene sequence:

>1860_bases
ATGTCCGCCGAAACTCCGTCCGCTTCGCCCGCCCCCCTGAACGCCCGTATCGGGGAGGTGACGGAGCGGATCGCGCAGCG
CAGCCGCGACCAGAGACAGCGCTATCTCGACCGCATCGCCGCCGCTGCCGCCCACAAGCCCCGCCGCCAGGCGCTGGGAT
GCGCCAACCAGGCCCATGGCTTCGCCGCCTGCGCTCCCGGCGACAAGGCGGTGCTGCGCGAGGGCCAGGGCGCGAGCCTC
GGCATCGTCACCGCCTATAACGACATGCTCTCCGCCCACCAGCCCTATGAGCGCTATCCGGAGCTGCTGCGCGAGGCCGC
CCGTGGCGTGGGCGGCGTGGCCCTGGTGGCCGGCGGCGTGCCCGCCATGTGCGACGGCGTCACCCAGGGCGAGGCCGGCA
TGGAGCTGTCTTTGTTCTCCCGCGACGTGATCGCGCTCTCCACCGCCGTGGCCCTCTCCCACCAGACCTTCGATGCGGCG
GTGTTCCTCGGCATCTGCGACAAGATCGTGCCGGGGCTGGTGATCGGGGCGCTGTCGTTCGGCCACCTGCCGGCGGTGTT
CATCCCGTCCGGTCCCATGACCTCGGGCCTGTCCAACACCGAGAAGTCGAAGATCCGCCAGCTGTTCGCGGAAGGAAAGG
TCGGCCGCGACGCGCTGCTGGAGGCGGAATCCAAATCCTACCACGGCCCCGGCACCTGCACCTTCTACGGCACCGCCAAC
ACCAACCAGATGCTCATGGAAATCATGGGCCTGCATCTGCCCGGCGCCTCCTTCGTGACCCCCGACACGCCGTTGCGCGA
TGCCCTCACCAGGGCGGCGGCGCAGCGGGCGCTGGCCATCACCGCGCTGGGCAACGATTACATCCCCGCCGGGCGGATGC
TGGACGAGAAGGCGTTCGTGAACGGCATCGTCGGCCTGCACGCCACCGGCGGCTCCACCAACCACACCCTGCATCTGGTG
GCCATGGCGGCGGCCGGCGGCATCGCCCTCACCTGGCAGGACTTTTCCGACCTCGCCGAGGTCACGCCCCTGCTCACCCG
GGTCTATCCCAACGGCACGGCGGACGTGAACCACTTCCACGCCGCCGGCGGCATGGCCTTCGTCATCCGCGAGCTTCTGG
GCGCAGGTCTCTTGCATGCCGATGCCGAGACCATCCTCGGGCGCGGGCTTGCGGCCTATACCAAGGAGCCGGTTCTGGCC
GAAGACGGCAGCCTTGCCTGGCGCGACGGCCCCGCCGTCACCGGTGACGCCAAGGTGCTGCGCACGGCGGCCGATCCGTT
CCAGGCCACCGGCGGGCTGAAGGTGCTCGACGGCAACATCGGCCGGGCGGTGATCAAGACCTCGGCGGTGGCCCCCGAGC
GCCACGTCATCGAGGCGCCGGCCCGGGTGTTCCATGCCCAGGAGGAGCTCCAGGCCGCCTTCAAGGCCGGCGAGCTGACA
GGCGACATGGTGGCGGTTCTGCGCTTCCAGGGCCCCAAGGCCAACGGCATGCCGGAGCTGCACAAGCTGATGCCGCCCTT
GGGCGTGCTGCAGGATCGCGGGCTGAAGGTGGCCCTCGTTACCGACGGGCGGCTGTCGGGGGCGTCGGGCAAGGTGCCCT
CGGCCATCCATGTGACGCCGGAAGCGGTGGACGGCGGCGCCATCGCCAAGGTGCGCGACGGCGACCTCATCCGCGTGGAC
GCGGTGGCCGGCACCCTCGAGGTTCTGGTCCCGGCCGCCGAATGGGCCGCCCGCCCGGCGGTGACCGTGGACCTCAGCGC
TTCCCACTCCGGCGTCGGCCGCGAGCTCTTCGCCCCCTTCCGAAACGCCGTCGGCCAGGCCGAAAAGGGCGCAAGCATTT
TCCAGGAGGTTTTCGCGTGA

Upstream 100 bases:

>100_bases
AGATGGTCGCAAGATGCGCGTATAAGAGCTGACGACAAGAAACCGATTGCCGGAAGAGCCGCCACAGGATCGGCGGATGC
CCTCCGGGAGGAGACCGCCA

Downstream 100 bases:

>100_bases
CCGATCAGATCCAGCCCGGGCTTCACTCCATTCTCTCCCGCGCCCCGGTGGTGCCCGTGGTGGTGGTGGAGCGCGCCGCC
GATGCCGTTCCGCTGGCCCG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MSAETPSASPAPLNARIGEVTERIAQRSRDQRQRYLDRIAAAAAHKPRRQALGCANQAHGFAACAPGDKAVLREGQGASL
GIVTAYNDMLSAHQPYERYPELLREAARGVGGVALVAGGVPAMCDGVTQGEAGMELSLFSRDVIALSTAVALSHQTFDAA
VFLGICDKIVPGLVIGALSFGHLPAVFIPSGPMTSGLSNTEKSKIRQLFAEGKVGRDALLEAESKSYHGPGTCTFYGTAN
TNQMLMEIMGLHLPGASFVTPDTPLRDALTRAAAQRALAITALGNDYIPAGRMLDEKAFVNGIVGLHATGGSTNHTLHLV
AMAAAGGIALTWQDFSDLAEVTPLLTRVYPNGTADVNHFHAAGGMAFVIRELLGAGLLHADAETILGRGLAAYTKEPVLA
EDGSLAWRDGPAVTGDAKVLRTAADPFQATGGLKVLDGNIGRAVIKTSAVAPERHVIEAPARVFHAQEELQAAFKAGELT
GDMVAVLRFQGPKANGMPELHKLMPPLGVLQDRGLKVALVTDGRLSGASGKVPSAIHVTPEAVDGGAIAKVRDGDLIRVD
AVAGTLEVLVPAAEWAARPAVTVDLSASHSGVGRELFAPFRNAVGQAEKGASIFQEVFA

Sequences:

>Translated_619_residues
MSAETPSASPAPLNARIGEVTERIAQRSRDQRQRYLDRIAAAAAHKPRRQALGCANQAHGFAACAPGDKAVLREGQGASL
GIVTAYNDMLSAHQPYERYPELLREAARGVGGVALVAGGVPAMCDGVTQGEAGMELSLFSRDVIALSTAVALSHQTFDAA
VFLGICDKIVPGLVIGALSFGHLPAVFIPSGPMTSGLSNTEKSKIRQLFAEGKVGRDALLEAESKSYHGPGTCTFYGTAN
TNQMLMEIMGLHLPGASFVTPDTPLRDALTRAAAQRALAITALGNDYIPAGRMLDEKAFVNGIVGLHATGGSTNHTLHLV
AMAAAGGIALTWQDFSDLAEVTPLLTRVYPNGTADVNHFHAAGGMAFVIRELLGAGLLHADAETILGRGLAAYTKEPVLA
EDGSLAWRDGPAVTGDAKVLRTAADPFQATGGLKVLDGNIGRAVIKTSAVAPERHVIEAPARVFHAQEELQAAFKAGELT
GDMVAVLRFQGPKANGMPELHKLMPPLGVLQDRGLKVALVTDGRLSGASGKVPSAIHVTPEAVDGGAIAKVRDGDLIRVD
AVAGTLEVLVPAAEWAARPAVTVDLSASHSGVGRELFAPFRNAVGQAEKGASIFQEVFA
>Mature_618_residues
SAETPSASPAPLNARIGEVTERIAQRSRDQRQRYLDRIAAAAAHKPRRQALGCANQAHGFAACAPGDKAVLREGQGASLG
IVTAYNDMLSAHQPYERYPELLREAARGVGGVALVAGGVPAMCDGVTQGEAGMELSLFSRDVIALSTAVALSHQTFDAAV
FLGICDKIVPGLVIGALSFGHLPAVFIPSGPMTSGLSNTEKSKIRQLFAEGKVGRDALLEAESKSYHGPGTCTFYGTANT
NQMLMEIMGLHLPGASFVTPDTPLRDALTRAAAQRALAITALGNDYIPAGRMLDEKAFVNGIVGLHATGGSTNHTLHLVA
MAAAGGIALTWQDFSDLAEVTPLLTRVYPNGTADVNHFHAAGGMAFVIRELLGAGLLHADAETILGRGLAAYTKEPVLAE
DGSLAWRDGPAVTGDAKVLRTAADPFQATGGLKVLDGNIGRAVIKTSAVAPERHVIEAPARVFHAQEELQAAFKAGELTG
DMVAVLRFQGPKANGMPELHKLMPPLGVLQDRGLKVALVTDGRLSGASGKVPSAIHVTPEAVDGGAIAKVRDGDLIRVDA
VAGTLEVLVPAAEWAARPAVTVDLSASHSGVGRELFAPFRNAVGQAEKGASIFQEVFA

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=62.7906976744186, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=537, Percent_Identity=30.3538175046555, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI2367371, Length=462, Percent_Identity=29.8701298701299, Blast_Score=135, Evalue=1e-32,
Organism=Escherichia coli, GI1786464, Length=466, Percent_Identity=29.8283261802575, Blast_Score=132, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322476, Length=473, Percent_Identity=32.1353065539112, Blast_Score=184, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64447; Mature: 64316

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAETPSASPAPLNARIGEVTERIAQRSRDQRQRYLDRIAAAAAHKPRRQALGCANQAHG
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHCCC
FAACAPGDKAVLREGQGASLGIVTAYNDMLSAHQPYERYPELLREAARGVGGVALVAGGV
EEEECCCCHHHHCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCC
PAMCDGVTQGEAGMELSLFSRDVIALSTAVALSHQTFDAAVFLGICDKIVPGLVIGALSF
HHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHLPAVFIPSGPMTSGLSNTEKSKIRQLFAEGKVGRDALLEAESKSYHGPGTCTFYGTAN
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEECCC
TNQMLMEIMGLHLPGASFVTPDTPLRDALTRAAAQRALAITALGNDYIPAGRMLDEKAFV
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHH
NGIVGLHATGGSTNHTLHLVAMAAAGGIALTWQDFSDLAEVTPLLTRVYPNGTADVNHFH
HHCEEEEECCCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHH
AAGGMAFVIRELLGAGLLHADAETILGRGLAAYTKEPVLAEDGSLAWRDGPAVTGDAKVL
HCCCHHHHHHHHHCCCHHHCCHHHHHHCCHHHHCCCCCEECCCCEEECCCCCCCCCHHHH
RTAADPFQATGGLKVLDGNIGRAVIKTSAVAPERHVIEAPARVFHAQEELQAAFKAGELT
HHCCCCHHCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDMVAVLRFQGPKANGMPELHKLMPPLGVLQDRGLKVALVTDGRLSGASGKVPSAIHVTP
CCEEEEEEECCCCCCCCHHHHHHCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECC
EAVDGGAIAKVRDGDLIRVDAVAGTLEVLVPAAEWAARPAVTVDLSASHSGVGRELFAPF
CCCCCCCEEEECCCCEEEEEEHHCCHHHEEEHHHHHCCCCEEEEECCCCCCCCHHHHHHH
RNAVGQAEKGASIFQEVFA
HHHHCCCHHHHHHHHHHHC
>Mature Secondary Structure 
SAETPSASPAPLNARIGEVTERIAQRSRDQRQRYLDRIAAAAAHKPRRQALGCANQAHG
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHCCC
FAACAPGDKAVLREGQGASLGIVTAYNDMLSAHQPYERYPELLREAARGVGGVALVAGGV
EEEECCCCHHHHCCCCCCEEEEEEEHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCC
PAMCDGVTQGEAGMELSLFSRDVIALSTAVALSHQTFDAAVFLGICDKIVPGLVIGALSF
HHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GHLPAVFIPSGPMTSGLSNTEKSKIRQLFAEGKVGRDALLEAESKSYHGPGTCTFYGTAN
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCEEEEEECCC
TNQMLMEIMGLHLPGASFVTPDTPLRDALTRAAAQRALAITALGNDYIPAGRMLDEKAFV
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCCHHHHHHHH
NGIVGLHATGGSTNHTLHLVAMAAAGGIALTWQDFSDLAEVTPLLTRVYPNGTADVNHFH
HHCEEEEECCCCCCCEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHH
AAGGMAFVIRELLGAGLLHADAETILGRGLAAYTKEPVLAEDGSLAWRDGPAVTGDAKVL
HCCCHHHHHHHHHCCCHHHCCHHHHHHCCHHHHCCCCCEECCCCEEECCCCCCCCCHHHH
RTAADPFQATGGLKVLDGNIGRAVIKTSAVAPERHVIEAPARVFHAQEELQAAFKAGELT
HHCCCCHHCCCCCEEEECCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GDMVAVLRFQGPKANGMPELHKLMPPLGVLQDRGLKVALVTDGRLSGASGKVPSAIHVTP
CCEEEEEEECCCCCCCCHHHHHHCCCHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEECC
EAVDGGAIAKVRDGDLIRVDAVAGTLEVLVPAAEWAARPAVTVDLSASHSGVGRELFAPF
CCCCCCCEEEECCCCEEEEEEHHCCHHHEEEHHHHHCCCCEEEEECCCCCCCCHHHHHHH
RNAVGQAEKGASIFQEVFA
HHHHCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]