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The map label for this gene is zwf [H]

Identifier: 154244967

GI number: 154244967

Start: 1167329

End: 1168804

Strand: Direct

Name: zwf [H]

Synonym: Xaut_1017

Alternate gene names: 154244967

Gene position: 1167329-1168804 (Clockwise)

Preceding gene: 154244966

Following gene: 154244968

Centisome position: 21.99

GC content: 68.29

Gene sequence:

>1476_bases
ATGTCGAGTCGCGTCATTCCGGTGCAACCCTTCGTCCTCACGGTGTTCGGCGCCACCGGGGACCTTGCCCGCCGCAAGCT
GCTGCCTGCGCTGTACCAGCGCGACCGGGCCGGACAATTGCCGGAGCGCGCCGCCATCGTCGGCGCCTCGCGCCAGCAGA
TGACGCCGGAGGCTTTCGTCGCCTTCGCCCGCGCCGCCATCACCGAATATGTGCCGGCCGGCGACCTCGAGGATGCGGAC
GTGGCCCGCTTCCTCGCCCGCCTCACCTATGTGCCGGTGGAGGCGGAAGGCGAGGGCGGCTGGCCGCAGCTTGCGGCCCT
CATCGCCACCCACACGGACATGATCCGGGTGTTCTATCTCGCCACCGGGCCGGCCCTGTTCGGCCCCATCTGCTCCCGGC
TCGGCGCCCACGGCATCGCCGTGGATGGTGCGCGGGTGGTGGTGGAGAAGCCGCTGGGCAAGAGCCTGGAGAGCGCTGTG
GCGCTCAACAAGGCCATCGGCGAAGTCTTCGAGGAGCGCAACGTCTACCGTATCGACCATTATCTCGGTAAGGAGACGGT
GCAGAACCTGATGGCGCTCAGGTTTGCCAATAACCTGTTCGAGCCGGTGTGGAACAACGCCCACATCGACCATGTGCAGA
TCACGGTCGCAGAAGACATCGGCACCGCCGGCCGTGCCGGTTACTATGACACCGCCGGCGCCCTGCGCGACATGGTGCAG
AACCACATTCTCCAATTGCTCTGCCTGGTGGCCATGGAGCCCCCCGTGTCGCTGGATGCGGATGCGGTGCGCGACGAGAA
GCTGAAGGTTCTCAAGGCGCTTTTGCCCATCACCGAGGCCAATGCCGGCCAGCTCACCGTGCGCGGCCAGTATCGCGCCG
GGGCCTCGGCGGGCGGGGCCGTGCCGGGCTATCTGGAGGAGCTGGGCTCTTCTACGTCCGAGACCGAGACCTTCGTGGCC
CTGAAGGCGGAGATCGGCAACTGGCGCTGGTCCGGCGTGCCGTTCTACCTGCGCACCGGCAAGAGGCTGGCCTCGCGGGT
GTCGGAGATCGTCATCACCTTCCGGCCGGTGCCCCATTCGGTGTTCGATGCGTCCGCCGGCACGCTGCGGGCCAACGTGC
TGGTGCTGCGGCTCCAACCGGAGGAGGGCGTGAAGCTGTGGCTGATGATCAAGGATCCCGGCCCCGGCGGCATGCGGCTT
GAGCATGTGCCCCTCGACATGAGCTTTGCCAGCGTCTTCGGCGTGCGCAATCCCGATGCCTATGAGCGCCTGCTCATGGA
CGTGGTGCGCGGCAACCAGACCCTGTTCATGCGCCGCGACGAGGTGGAGGCGGCGTGGCGCTGGGTGGACCCGATCCTCG
AGGCGTGGCGCGCCTCCCGCGAGCCGCCCAAGCCCTATACCGCCGGCACCTGGGGCCCCGCTGCCGCCATCGCCCTCATC
GAGCGCGACGGCCGGACCTGGTCCGGCGACGACTGA

Upstream 100 bases:

>100_bases
CAGCCGCATAAATCTCGCCGAGCCTCCCCGGCTCGTGCCGCACCCAGGCGCCGGACCCGCAGTCCCGGCCTGGCGGGCCC
CACTGCAAGGCGAATCTCCG

Downstream 100 bases:

>100_bases
ACGCCTGTTTTCGCTTGCACCCTGCCGGACTTGACCGGCAGGGTCGCGCCAAAAGCTGGCTCGTGCCAACAGATGGTCGC
AAGATGCGCGTATAAGAGCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSSRVIPVQPFVLTVFGATGDLARRKLLPALYQRDRAGQLPERAAIVGASRQQMTPEAFVAFARAAITEYVPAGDLEDAD
VARFLARLTYVPVEAEGEGGWPQLAALIATHTDMIRVFYLATGPALFGPICSRLGAHGIAVDGARVVVEKPLGKSLESAV
ALNKAIGEVFEERNVYRIDHYLGKETVQNLMALRFANNLFEPVWNNAHIDHVQITVAEDIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALLPITEANAGQLTVRGQYRAGASAGGAVPGYLEELGSSTSETETFVA
LKAEIGNWRWSGVPFYLRTGKRLASRVSEIVITFRPVPHSVFDASAGTLRANVLVLRLQPEEGVKLWLMIKDPGPGGMRL
EHVPLDMSFASVFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWRWVDPILEAWRASREPPKPYTAGTWGPAAAIALI
ERDGRTWSGDD

Sequences:

>Translated_491_residues
MSSRVIPVQPFVLTVFGATGDLARRKLLPALYQRDRAGQLPERAAIVGASRQQMTPEAFVAFARAAITEYVPAGDLEDAD
VARFLARLTYVPVEAEGEGGWPQLAALIATHTDMIRVFYLATGPALFGPICSRLGAHGIAVDGARVVVEKPLGKSLESAV
ALNKAIGEVFEERNVYRIDHYLGKETVQNLMALRFANNLFEPVWNNAHIDHVQITVAEDIGTAGRAGYYDTAGALRDMVQ
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALLPITEANAGQLTVRGQYRAGASAGGAVPGYLEELGSSTSETETFVA
LKAEIGNWRWSGVPFYLRTGKRLASRVSEIVITFRPVPHSVFDASAGTLRANVLVLRLQPEEGVKLWLMIKDPGPGGMRL
EHVPLDMSFASVFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWRWVDPILEAWRASREPPKPYTAGTWGPAAAIALI
ERDGRTWSGDD
>Mature_490_residues
SSRVIPVQPFVLTVFGATGDLARRKLLPALYQRDRAGQLPERAAIVGASRQQMTPEAFVAFARAAITEYVPAGDLEDADV
ARFLARLTYVPVEAEGEGGWPQLAALIATHTDMIRVFYLATGPALFGPICSRLGAHGIAVDGARVVVEKPLGKSLESAVA
LNKAIGEVFEERNVYRIDHYLGKETVQNLMALRFANNLFEPVWNNAHIDHVQITVAEDIGTAGRAGYYDTAGALRDMVQN
HILQLLCLVAMEPPVSLDADAVRDEKLKVLKALLPITEANAGQLTVRGQYRAGASAGGAVPGYLEELGSSTSETETFVAL
KAEIGNWRWSGVPFYLRTGKRLASRVSEIVITFRPVPHSVFDASAGTLRANVLVLRLQPEEGVKLWLMIKDPGPGGMRLE
HVPLDMSFASVFGVRNPDAYERLLMDVVRGNQTLFMRRDEVEAAWRWVDPILEAWRASREPPKPYTAGTWGPAAAIALIE
RDGRTWSGDD

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=39.7540983606557, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=39.7540983606557, Blast_Score=329, Evalue=3e-90,
Organism=Homo sapiens, GI52145310, Length=490, Percent_Identity=30.4081632653061, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788158, Length=483, Percent_Identity=49.6894409937888, Blast_Score=482, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17538218, Length=492, Percent_Identity=37.8048780487805, Blast_Score=335, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=36.1746361746362, Blast_Score=292, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24643352, Length=488, Percent_Identity=37.0901639344262, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24643350, Length=488, Percent_Identity=37.0901639344262, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI221513548, Length=496, Percent_Identity=30.8467741935484, Blast_Score=217, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 53720; Mature: 53589

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRVIPVQPFVLTVFGATGDLARRKLLPALYQRDRAGQLPERAAIVGASRQQMTPEAFV
CCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHCCHHHHH
AFARAAITEYVPAGDLEDADVARFLARLTYVPVEAEGEGGWPQLAALIATHTDMIRVFYL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEEEE
ATGPALFGPICSRLGAHGIAVDGARVVVEKPLGKSLESAVALNKAIGEVFEERNVYRIDH
ECCHHHHHHHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEHH
YLGKETVQNLMALRFANNLFEPVWNNAHIDHVQITVAEDIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALLPITEANAGQLTVRGQYRAGASAGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCC
VPGYLEELGSSTSETETFVALKAEIGNWRWSGVPFYLRTGKRLASRVSEIVITFRPVPHS
CCHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHEEEEEECCCCH
VFDASAGTLRANVLVLRLQPEEGVKLWLMIKDPGPGGMRLEHVPLDMSFASVFGVRNPDA
HHCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLLMDVVRGNQTLFMRRDEVEAAWRWVDPILEAWRASREPPKPYTAGTWGPAAAIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEE
ERDGRTWSGDD
ECCCCCCCCCC
>Mature Secondary Structure 
SSRVIPVQPFVLTVFGATGDLARRKLLPALYQRDRAGQLPERAAIVGASRQQMTPEAFV
CCCCEECCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCHHHCCHHHHH
AFARAAITEYVPAGDLEDADVARFLARLTYVPVEAEGEGGWPQLAALIATHTDMIRVFYL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHEEEEEE
ATGPALFGPICSRLGAHGIAVDGARVVVEKPLGKSLESAVALNKAIGEVFEERNVYRIDH
ECCHHHHHHHHHHHCCCCEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEHH
YLGKETVQNLMALRFANNLFEPVWNNAHIDHVQITVAEDIGTAGRAGYYDTAGALRDMVQ
HHCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHH
NHILQLLCLVAMEPPVSLDADAVRDEKLKVLKALLPITEANAGQLTVRGQYRAGASAGGA
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCC
VPGYLEELGSSTSETETFVALKAEIGNWRWSGVPFYLRTGKRLASRVSEIVITFRPVPHS
CCHHHHHHCCCCCCCEEEEEEEEECCCEEECCCCEEECCCHHHHHHHHHEEEEEECCCCH
VFDASAGTLRANVLVLRLQPEEGVKLWLMIKDPGPGGMRLEHVPLDMSFASVFGVRNPDA
HHCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCEEEECCCCCHHHHHHCCCCCHH
YERLLMDVVRGNQTLFMRRDEVEAAWRWVDPILEAWRASREPPKPYTAGTWGPAAAIALI
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEEE
ERDGRTWSGDD
ECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]