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The map label for this gene is yisK [H]

Identifier: 154244877

GI number: 154244877

Start: 1045374

End: 1046219

Strand: Reverse

Name: yisK [H]

Synonym: Xaut_0927

Alternate gene names: 154244877

Gene position: 1046219-1045374 (Counterclockwise)

Preceding gene: 154244878

Following gene: 154244876

Centisome position: 19.71

GC content: 66.43

Gene sequence:

>846_bases
ATGAAGTTTGCTTCCTTCACCCATGCCGGCCGTGCCGGTTACGGCCTCGTGACGGACGGAGGGATCATCGATCTCACCCG
CCGCTTCCCCGAAGCGCCGACCTTGCGGACCTTCATCGCCGGCGGGCTGGATCGTGCCGCCGCCGTCGCCGGCGCGCCGG
CGGATTTCGCCTTGTCCGAGGTGACGCTCGCTCCGGTCATTCCAGACCCGGACAAGATCGTCTGCGTGGGCCTCAACTAC
CATGACCATGTGAACGAGACGGGACGCACGGTCACCCCCAATCCCATGCTGTTCGCGCGGTACGCTGGAAGCCAGGTCGG
CGCTGGCACGGCCCTGGTGAAGCCGCTGGAATCCGACGAGTTCGACTATGAAGGCGAACTTGCCGTCATCATCGGCAAGG
CCGGCCGGCGCATCTCCGAGGCCGACGCCCTCTCCCATGTGGCGGGCTATGCCTGCTATAATGATGCCAGTGTGCGCGAC
TGGCAGCGCCACACCTCGCAGTTCATGCCCGGCAAGACCTTTGCCGCCACCGGCGCCTTCGGCCCCTGGATGGTGAGCGC
CGACGAGATCCCCGATCCCACGCGCCTCACCCTCGCCACCCGCCTCAACGGCGCGCAGGTGCAGCACACGAGCGTGGATC
TGATGATCACCCCCATCCCCACGTTGATCGCCTACACCTCCACCATCCTGCCCCTGCTGCCTGGCGATGTGATCGTCTCC
GGCACGCCTGGAGGCGTGGGGGCGCGTCGCACGCCCAAGCTGTTCATGAAGGACGGCGATGTGGTGGAAGTCGAGGTCAG
CGGCATCGGCGTGTTGCGCAACCCCATCGTCGCCGAGCTTGCCTGA

Upstream 100 bases:

>100_bases
CCGCAACACGCTTCCGCCGCCTGATCCGCACCCGCGAACCGCGCGACCGCGCCAATCCCCCTCCTCACCAAGATGATGCT
CAAGGAAAAGGTTTGCCCCG

Downstream 100 bases:

>100_bases
GGCTCGCCCGCAGGTCATTCCATCAGGGAGTGTTGAAGCATGCCGGCCCGGGCAAGTCTGGGCACGGCATGTTCAAAACG
TATACCATGTGAACCAAAAG

Product: 5-carboxymethyl-2-hydroxymuconate delta-isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MKFASFTHAGRAGYGLVTDGGIIDLTRRFPEAPTLRTFIAGGLDRAAAVAGAPADFALSEVTLAPVIPDPDKIVCVGLNY
HDHVNETGRTVTPNPMLFARYAGSQVGAGTALVKPLESDEFDYEGELAVIIGKAGRRISEADALSHVAGYACYNDASVRD
WQRHTSQFMPGKTFAATGAFGPWMVSADEIPDPTRLTLATRLNGAQVQHTSVDLMITPIPTLIAYTSTILPLLPGDVIVS
GTPGGVGARRTPKLFMKDGDVVEVEVSGIGVLRNPIVAELA

Sequences:

>Translated_281_residues
MKFASFTHAGRAGYGLVTDGGIIDLTRRFPEAPTLRTFIAGGLDRAAAVAGAPADFALSEVTLAPVIPDPDKIVCVGLNY
HDHVNETGRTVTPNPMLFARYAGSQVGAGTALVKPLESDEFDYEGELAVIIGKAGRRISEADALSHVAGYACYNDASVRD
WQRHTSQFMPGKTFAATGAFGPWMVSADEIPDPTRLTLATRLNGAQVQHTSVDLMITPIPTLIAYTSTILPLLPGDVIVS
GTPGGVGARRTPKLFMKDGDVVEVEVSGIGVLRNPIVAELA
>Mature_281_residues
MKFASFTHAGRAGYGLVTDGGIIDLTRRFPEAPTLRTFIAGGLDRAAAVAGAPADFALSEVTLAPVIPDPDKIVCVGLNY
HDHVNETGRTVTPNPMLFARYAGSQVGAGTALVKPLESDEFDYEGELAVIIGKAGRRISEADALSHVAGYACYNDASVRD
WQRHTSQFMPGKTFAATGAFGPWMVSADEIPDPTRLTLATRLNGAQVQHTSVDLMITPIPTLIAYTSTILPLLPGDVIVS
GTPGGVGARRTPKLFMKDGDVVEVEVSGIGVLRNPIVAELA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=266, Percent_Identity=40.9774436090226, Blast_Score=198, Evalue=4e-51,
Organism=Homo sapiens, GI40786394, Length=266, Percent_Identity=40.6015037593985, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI13654274, Length=204, Percent_Identity=35.2941176470588, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI215422413, Length=201, Percent_Identity=34.8258706467662, Blast_Score=117, Evalue=9e-27,
Organism=Homo sapiens, GI66348062, Length=203, Percent_Identity=34.4827586206897, Blast_Score=117, Evalue=9e-27,
Organism=Escherichia coli, GI1787428, Length=180, Percent_Identity=33.8888888888889, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17557057, Length=196, Percent_Identity=35.7142857142857, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28572127, Length=221, Percent_Identity=39.3665158371041, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI24663695, Length=286, Percent_Identity=30.0699300699301, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28571789, Length=222, Percent_Identity=30.6306306306306, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 29673; Mature: 29673

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFASFTHAGRAGYGLVTDGGIIDLTRRFPEAPTLRTFIAGGLDRAAAVAGAPADFALSE
CCCCCCCCCCCCCCEEEECCCEEEHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCEEEE
VTLAPVIPDPDKIVCVGLNYHDHVNETGRTVTPNPMLFARYAGSQVGAGTALVKPLESDE
EEEECCCCCCCCEEEEECCCHHCCCCCCCEECCCCEEEEEECCCCCCCCHHEECCCCCCC
FDYEGELAVIIGKAGRRISEADALSHVAGYACYNDASVRDWQRHTSQFMPGKTFAATGAF
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCEEECCCC
GPWMVSADEIPDPTRLTLATRLNGAQVQHTSVDLMITPIPTLIAYTSTILPLLPGDVIVS
CCEEEECCCCCCCCEEEEEEECCCCEEEEEEEEEEEECHHHHHHHHHHHHHCCCCCEEEE
GTPGGVGARRTPKLFMKDGDVVEVEVSGIGVLRNPIVAELA
CCCCCCCCCCCCEEEECCCCEEEEEECCCEEECCCCHHHCC
>Mature Secondary Structure
MKFASFTHAGRAGYGLVTDGGIIDLTRRFPEAPTLRTFIAGGLDRAAAVAGAPADFALSE
CCCCCCCCCCCCCCEEEECCCEEEHHHHCCCCCCHHHHHHCCCCHHHHHCCCCCCCEEEE
VTLAPVIPDPDKIVCVGLNYHDHVNETGRTVTPNPMLFARYAGSQVGAGTALVKPLESDE
EEEECCCCCCCCEEEEECCCHHCCCCCCCEECCCCEEEEEECCCCCCCCHHEECCCCCCC
FDYEGELAVIIGKAGRRISEADALSHVAGYACYNDASVRDWQRHTSQFMPGKTFAATGAF
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHCCCCCCEEECCCC
GPWMVSADEIPDPTRLTLATRLNGAQVQHTSVDLMITPIPTLIAYTSTILPLLPGDVIVS
CCEEEECCCCCCCCEEEEEEECCCCEEEEEEEEEEEECHHHHHHHHHHHHHCCCCCEEEE
GTPGGVGARRTPKLFMKDGDVVEVEVSGIGVLRNPIVAELA
CCCCCCCCCCCCEEEECCCCEEEEEECCCEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]