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The map label for this gene is glyA2 [H]

Identifier: 154244820

GI number: 154244820

Start: 969928

End: 971202

Strand: Reverse

Name: glyA2 [H]

Synonym: Xaut_0870

Alternate gene names: 154244820

Gene position: 971202-969928 (Counterclockwise)

Preceding gene: 154244821

Following gene: 154244819

Centisome position: 18.29

GC content: 69.8

Gene sequence:

>1275_bases
ATGACCCTTCACGTTGCCCCGACCCACGCCGCCGACCCCGCCGTGTTCGACGCCATCCGCGCCGAGCTGAAGCGCCAGCA
GGACCAGATCGAGCTGATCGCCTCGGAGAACATCGTGTCCGAGGCGGTGCTGGCGGCGCAGGGCTCGGTGCTCACCAACA
AGTATGCCGAGGGCCTGCCGGGCAAGCGCTACTACGGCGGCTGCGAGCATGTGGACGTGGTGGAGGAGATCGCCATCGCC
CGCGCCAAGGCGCTGTTCGGCGCCGGCTTCGCCAATGTGCAGCCGCACTCGGGCGCGCAGGCCAATGCGGCGGTGCTGAT
GGCCCTGCTCCAGCCCGGCGACACCCTGCTCGGCATGTCGCTGGCGGCGGGCGGGCATCTCACCCACGGCGCGCCGCCCA
CGCTCTCCGGCAAGTGGTTCAAGGCCATCGGCTATGGCGTGACGCGCGACAACGCACTCATCGACTATGACGAGGTGGAG
CGCCTGGCGCAGGAGCACAGGCCCAAGCTCATCATCGCCGGCGGCTCGTCCTATCCGCGCATCATCGATTTCGCCCGCTT
CCGTGCCATCGCCGATGCGGTGGGCGCGCACCTGATGGTGGATGCGGCCCACTATGCCGGGCTCATCGTGGCGGGGGCCT
ATCCTTCCCCCTTCCCCCATGCCCACGTGGTGACGACCACCACCCACAAGACCCTGCGCGGACCGCGCGGCGGCCTCATC
CTTACCAATGACGAGGCGCTAGCGAAGAAGCTGAACTCGGCGGTCTTCCCCGGCCTCCAGGGCGGCCCCCTGATGCATGT
GATCGCGGCCAAGGCGGTGGCCTTCGGCGAGGCCCTCACCGACGATTTCCGCACCTATGCGCTCAAGGTGGTCTCCAACG
CGCGGGCGCTGGCCGGCCGGCTGTCCGAGCGCGGGGCGGCCATCGTCTCGGGAGGCACCGACAGCCACATGGTGCTGGTG
GACCTGCGGCCCTTCGGCGTCACCGGCAAGGCGGCGGAAGCCGCTCTCGAGCGAGCCGGCCTCACCTGCAACAAGAACGG
CATCCCGTTCGATCCGGAAAAGCCGTTCGTGACCTCGGGCATCCGCCTCGGCACCCCGGCCGGCACCACGCGCGGCTTCG
GCATCGCCGAGTTCGAAGAGGTCGGCGACCTCATCGCCGACGTGCTCACCGGCCTTGCGGCCAATGGCGCCGAAGCCAAC
GGCAAGGCGGAGGTGGCGACCCGCGCCAGGGTGGCCGAGCTGTGCGCCCGCTTCCCGCTCTATGCGGGGATGTGA

Upstream 100 bases:

>100_bases
TCCAAATACAAGGAAACCTCGCAGGGCGGCCTCGCGGTCAACGTGCCGGAATGCTGAGCCGCCCCGCCCATCCCCATCCC
TTCCAGAAGGACCAACGCCC

Downstream 100 bases:

>100_bases
GGGGCCCGTGTCCCTGCCGACTAAAGCGTGAGCGGAGGGAGGGCAGGAGCGCCGCTACCCCCTTGAACCGCCGTCATGCC
CGGCCCTGTGCCGGGCATCC

Product: glycine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 2; Serine methylase 2 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MTLHVAPTHAADPAVFDAIRAELKRQQDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHVDVVEEIAIA
RAKALFGAGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFKAIGYGVTRDNALIDYDEVE
RLAQEHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHVVTTTTHKTLRGPRGGLI
LTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALTDDFRTYALKVVSNARALAGRLSERGAAIVSGGTDSHMVLV
DLRPFGVTGKAAEAALERAGLTCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGIAEFEEVGDLIADVLTGLAANGAEAN
GKAEVATRARVAELCARFPLYAGM

Sequences:

>Translated_424_residues
MTLHVAPTHAADPAVFDAIRAELKRQQDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHVDVVEEIAIA
RAKALFGAGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFKAIGYGVTRDNALIDYDEVE
RLAQEHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHVVTTTTHKTLRGPRGGLI
LTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALTDDFRTYALKVVSNARALAGRLSERGAAIVSGGTDSHMVLV
DLRPFGVTGKAAEAALERAGLTCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGIAEFEEVGDLIADVLTGLAANGAEAN
GKAEVATRARVAELCARFPLYAGM
>Mature_423_residues
TLHVAPTHAADPAVFDAIRAELKRQQDQIELIASENIVSEAVLAAQGSVLTNKYAEGLPGKRYYGGCEHVDVVEEIAIAR
AKALFGAGFANVQPHSGAQANAAVLMALLQPGDTLLGMSLAAGGHLTHGAPPTLSGKWFKAIGYGVTRDNALIDYDEVER
LAQEHRPKLIIAGGSSYPRIIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHVVTTTTHKTLRGPRGGLIL
TNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALTDDFRTYALKVVSNARALAGRLSERGAAIVSGGTDSHMVLVD
LRPFGVTGKAAEAALERAGLTCNKNGIPFDPEKPFVTSGIRLGTPAGTTRGFGIAEFEEVGDLIADVLTGLAANGAEANG
KAEVATRARVAELCARFPLYAGM

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=398, Percent_Identity=48.4924623115578, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI261862352, Length=443, Percent_Identity=45.823927765237, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI261862350, Length=443, Percent_Identity=45.823927765237, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI261862348, Length=443, Percent_Identity=45.823927765237, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI261862346, Length=398, Percent_Identity=47.4874371859297, Blast_Score=327, Evalue=9e-90,
Organism=Homo sapiens, GI22547186, Length=405, Percent_Identity=46.9135802469136, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=44.0721649484536, Blast_Score=283, Evalue=3e-76,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=58.2125603864734, Blast_Score=455, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=49.2424242424242, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=396, Percent_Identity=49.2424242424242, Blast_Score=353, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=440, Percent_Identity=43.6363636363636, Blast_Score=348, Evalue=8e-97,
Organism=Saccharomyces cerevisiae, GI6323087, Length=408, Percent_Identity=44.3627450980392, Blast_Score=323, Evalue=4e-89,
Organism=Drosophila melanogaster, GI24640005, Length=456, Percent_Identity=43.640350877193, Blast_Score=346, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221329721, Length=456, Percent_Identity=43.640350877193, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44264; Mature: 44133

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLHVAPTHAADPAVFDAIRAELKRQQDQIELIASENIVSEAVLAAQGSVLTNKYAEGLP
CEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
GKRYYGGCEHVDVVEEIAIARAKALFGAGFANVQPHSGAQANAAVLMALLQPGDTLLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHH
LAAGGHLTHGAPPTLSGKWFKAIGYGVTRDNALIDYDEVERLAQEHRPKLIIAGGSSYPR
HHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECHHHHHHHHHHCCCEEEEECCCCCCH
IIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHEEEHHHHCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCEE
LTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALTDDFRTYALKVVSNARALAGR
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSERGAAIVSGGTDSHMVLVDLRPFGVTGKAAEAALERAGLTCNKNGIPFDPEKPFVTSG
HHHCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCHHCCC
IRLGTPAGTTRGFGIAEFEEVGDLIADVLTGLAANGAEANGKAEVATRARVAELCARFPL
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCH
YAGM
HCCC
>Mature Secondary Structure 
TLHVAPTHAADPAVFDAIRAELKRQQDQIELIASENIVSEAVLAAQGSVLTNKYAEGLP
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCC
GKRYYGGCEHVDVVEEIAIARAKALFGAGFANVQPHSGAQANAAVLMALLQPGDTLLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHH
LAAGGHLTHGAPPTLSGKWFKAIGYGVTRDNALIDYDEVERLAQEHRPKLIIAGGSSYPR
HHCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECHHHHHHHHHHCCCEEEEECCCCCCH
IIDFARFRAIADAVGAHLMVDAAHYAGLIVAGAYPSPFPHAHVVTTTTHKTLRGPRGGLI
HHHHHHHHHHHHHHHHHHEEEHHHHCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCEE
LTNDEALAKKLNSAVFPGLQGGPLMHVIAAKAVAFGEALTDDFRTYALKVVSNARALAGR
EECCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSERGAAIVSGGTDSHMVLVDLRPFGVTGKAAEAALERAGLTCNKNGIPFDPEKPFVTSG
HHHCCCEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCCCCHHCCC
IRLGTPAGTTRGFGIAEFEEVGDLIADVLTGLAANGAEANGKAEVATRARVAELCARFPL
EEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCH
YAGM
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA