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The map label for this gene is lpxC

Identifier: 154244286

GI number: 154244286

Start: 341157

End: 342092

Strand: Direct

Name: lpxC

Synonym: Xaut_0329

Alternate gene names: 154244286

Gene position: 341157-342092 (Clockwise)

Preceding gene: 154244285

Following gene: 154244287

Centisome position: 6.43

GC content: 68.38

Gene sequence:

>936_bases
ATGCAGACGACACTGGCTCGCGAGATCACGCTCAAAGGTGCGGGTGTCCATGCGGCTGTCGACGCCACCGTCACTTTGAA
GCCTGCCCTCGCGAACACTGGTATCGTCTTCGTCCGCTCCTTCGCCGATCAGGCGCCCCGCAAGGCCACCGTGAGCCGCA
CTTCGGTTCAGGCCACCGACCTTGCCACCGTCCTTGGCGATCGCTCCGGCGCCCTTGTCTCGACTGTCGAGCATCTTCTC
GCGGCCTTCCACGGCTTGGCGATCGACAATGCCCTGGTGGAGATCGACGGGCCGGAAGTTCCGATCCTCGACGGCAGCGC
CGCCCAGTTCGTGGCCGCGATCGATGCCGCCGGCGTCACCGAGGTGCGCGGCCGCCGCAAGTATCTCAAGGTGCTGAAGC
CGGTTCGGGTGGAGAACGGCGCCTCCTTCGGCGAGCTCCTGCCCTATGACGCGGGCTTTCGCCTGGAAGTGGAAATCGAG
TTCGCCCACGACGCCATCGGACGCCAGCGCTTTGCCGCCACCATGTCCCCCGCCGTGTTCCGCCGCGAACTGGCCGGTGC
CCGCACCTTCGGCTTCCTGAAGGATGTGGAGCGCCTGCGCGCTGCCGGCTATGCCCGCGGCGCGGCGCTGGAGAACACCG
TGTGCCTCGACGAGGCCGGCGTGATGAACGAGGGCGGCCTGCGCTTCACCGACGAATTCGTGCGGCACAAGGCCCTCGAC
GCGGTGGGTGACCTGGCCCTTTCCGGCCTGCCCCTGCTCGCCCGCTATCGCTCCTTCCGCGGCGGCCACAAGCTGAACTA
CCAGGTGGTGGACGCCCTCTTCTCCGACCGCTCCGCCTATGCGGTGGTGGAGGCCCCGGCCCGTCCCGTGCGCGACACGG
TGGGTGCCGACATGGGTGTCTCGGCCCCGGTGCCGGTGTTCGCTCCGGAAGTCTGA

Upstream 100 bases:

>100_bases
ACAACCGAGGCGAAAGTGGGAACGCAAGGTGAAGGTTTGAGGGACGGGTTGCGGCGGCCATGAGGCACCGGACCCCATCT
CCGATACGGGACGCATCGAC

Downstream 100 bases:

>100_bases
CCGGCTCTTTGATCGCATTAAAGCGGCGCCCCACGCGGGCGCCGTTTGCGTTTGAGGCGGCCTTCGCGGGTGGTTCGGAC
CGGTGCTTGCGGTTTTTTAA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MQTTLAREITLKGAGVHAAVDATVTLKPALANTGIVFVRSFADQAPRKATVSRTSVQATDLATVLGDRSGALVSTVEHLL
AAFHGLAIDNALVEIDGPEVPILDGSAAQFVAAIDAAGVTEVRGRRKYLKVLKPVRVENGASFGELLPYDAGFRLEVEIE
FAHDAIGRQRFAATMSPAVFRRELAGARTFGFLKDVERLRAAGYARGAALENTVCLDEAGVMNEGGLRFTDEFVRHKALD
AVGDLALSGLPLLARYRSFRGGHKLNYQVVDALFSDRSAYAVVEAPARPVRDTVGADMGVSAPVPVFAPEV

Sequences:

>Translated_311_residues
MQTTLAREITLKGAGVHAAVDATVTLKPALANTGIVFVRSFADQAPRKATVSRTSVQATDLATVLGDRSGALVSTVEHLL
AAFHGLAIDNALVEIDGPEVPILDGSAAQFVAAIDAAGVTEVRGRRKYLKVLKPVRVENGASFGELLPYDAGFRLEVEIE
FAHDAIGRQRFAATMSPAVFRRELAGARTFGFLKDVERLRAAGYARGAALENTVCLDEAGVMNEGGLRFTDEFVRHKALD
AVGDLALSGLPLLARYRSFRGGHKLNYQVVDALFSDRSAYAVVEAPARPVRDTVGADMGVSAPVPVFAPEV
>Mature_311_residues
MQTTLAREITLKGAGVHAAVDATVTLKPALANTGIVFVRSFADQAPRKATVSRTSVQATDLATVLGDRSGALVSTVEHLL
AAFHGLAIDNALVEIDGPEVPILDGSAAQFVAAIDAAGVTEVRGRRKYLKVLKPVRVENGASFGELLPYDAGFRLEVEIE
FAHDAIGRQRFAATMSPAVFRRELAGARTFGFLKDVERLRAAGYARGAALENTVCLDEAGVMNEGGLRFTDEFVRHKALD
AVGDLALSGLPLLARYRSFRGGHKLNYQVVDALFSDRSAYAVVEAPARPVRDTVGADMGVSAPVPVFAPEV

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=284, Percent_Identity=40.4929577464789, Blast_Score=227, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 33072; Mature: 33072

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTTLAREITLKGAGVHAAVDATVTLKPALANTGIVFVRSFADQAPRKATVSRTSVQATD
CCCCCCCEEEEECCCEEEEEEEEEEECCHHCCCCCEEEEHHHHCCCCCHHHHHCCCHHHH
LATVLGDRSGALVSTVEHLLAAFHGLAIDNALVEIDGPEVPILDGSAAQFVAAIDAAGVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCHHHHHHHHHHCCHH
EVRGRRKYLKVLKPVRVENGASFGELLPYDAGFRLEVEIEFAHDAIGRQRFAATMSPAVF
HHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCHHHH
RRELAGARTFGFLKDVERLRAAGYARGAALENTVCLDEAGVMNEGGLRFTDEFVRHKALD
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHH
AVGDLALSGLPLLARYRSFRGGHKLNYQVVDALFSDRSAYAVVEAPARPVRDTVGADMGV
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCC
SAPVPVFAPEV
CCCCCCCCCCC
>Mature Secondary Structure
MQTTLAREITLKGAGVHAAVDATVTLKPALANTGIVFVRSFADQAPRKATVSRTSVQATD
CCCCCCCEEEEECCCEEEEEEEEEEECCHHCCCCCEEEEHHHHCCCCCHHHHHCCCHHHH
LATVLGDRSGALVSTVEHLLAAFHGLAIDNALVEIDGPEVPILDGSAAQFVAAIDAAGVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCEEECCCHHHHHHHHHHCCHH
EVRGRRKYLKVLKPVRVENGASFGELLPYDAGFRLEVEIEFAHDAIGRQRFAATMSPAVF
HHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCHHHH
RRELAGARTFGFLKDVERLRAAGYARGAALENTVCLDEAGVMNEGGLRFTDEFVRHKALD
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHH
AVGDLALSGLPLLARYRSFRGGHKLNYQVVDALFSDRSAYAVVEAPARPVRDTVGADMGV
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHCCCCCC
SAPVPVFAPEV
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA