Click here to switch to the map view.

The map label for this gene is mdtA [H]

Identifier: 154244277

GI number: 154244277

Start: 330498

End: 331721

Strand: Reverse

Name: mdtA [H]

Synonym: Xaut_0320

Alternate gene names: 154244277

Gene position: 331721-330498 (Counterclockwise)

Preceding gene: 154244278

Following gene: 154244276

Centisome position: 6.25

GC content: 73.12

Gene sequence:

>1224_bases
ATGACCGCCCCGATCAGCACCGCACCCCGCACCGCCCGCCTGCGCAACCGCCTCCTCCTCGGCACCGTGGCCCTCGCCGC
CGTCCTGGGCACGCTCTACGGCCTGCCACAGACCCGCGCCCATGCGGAGAAGCCGGCGGCGGCAGCGCCCACAGCCGTGC
CGGTCTCCGTCGCCACCGTGGAGCCCCGCGATGCGCGGCTGTTCGAGACCTTCTCCGGCCGCCTCGAGGCGGTGGAGCGG
GTGGAGGTGCGCTCCCGCGTCGCCGGCGCCATCAAGGCCATCCATTTCCGCGAGGGCGCTCTGGTGCGCGAAGGCGAATT
GCTCGTCTCCATCGATCCCGAGCCGTTTGAAGCGGAAGTCGCCGAGGCCGAGGCCCAGGTGGCCGCCGCCCAGGCCCGCG
TGGAACTCGCCCGCAACGAGCTGGAGCGCGGCCAGCGCCTGTGGACCTCCCGCACCGTCTCCCAGCGCGATCTCGACGAG
CGCGTCAACGGCCAGCGCGCCGCCGAGGCGGCCCTGCGCGCGGTCGAGGCCAAGCTCACCTCGGCCAAGCTCAGCCTCTC
CTACACCCGCGTCCGCGCCCCGGTGTCGGGACGGGTGGGCAAATCGGAGATCACGGTGGGCAACCTGGTTGCCGCCGGCC
CCGGCGCGCCGGTGCTCACCACTTTGGTGTCGGTGGACCCCATCTATGCCAGCTTCAATGCGGACGAGGCCACCGTCTCC
CGCGCACTCGCCGGGCTCGGCGCCAGCGCGGATGTCTCCGACCAGCTCGACCGCATCCCCGTGCTCATGACCACCTCCGC
CGGTGGCACGCCGGTGGAAGGCCACATGCAGCTGGTGGACAACCAGGTGGACGTGCGCACCGGCACGGTGCGGGTGCGCG
CCCGCTTCGCCAATGCCGACGGGCGGCTCCTGCCCGGCCAGTTCGCGCGCCTTGAGATGGGCCAGCCTGTCAGCGAGCCG
GCCCTTCTCGTGAGCGAGCGGGCGGTGGGCACCGACCAGGACAAGAAGTTCGTCTTCGTGGTGGATGCCGCCAACACGGC
GGTGTGGCGCGAGGTCACGCTCGGCGCCCCCGTGGATGGCCTGCGCGTGGTCACCAGCGGGCTGAAGGCGGGCGAGCGCA
TCGTCGTCAACGGCCTCCACCGCGTGCGCCCCGGCGCGCCGGTGGCACCCCAGAGCGTGCCCATGCGGGTGACGGAAGCG
GCGCCCGCGACCCTCGCCAACTGA

Upstream 100 bases:

>100_bases
GTTCTCCCGCTTCTTCGAAACGTCCCGACCGCGTCGGCGCAAGCCGGCCCCGGCCGTCCTCTGACCGCCGAACATCCAGA
ACTCCCCCAGGATCTGCCCC

Downstream 100 bases:

>100_bases
CGCCGCGCGCCGTTACCCCCCGGCCGGACCGGGGAATAACGCGCAGCGTCTGAACCGGATTTAGATCCCTCTCCCCCGCA
TGGGAGAGGGCGGGTGAGGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTAPISTAPRTARLRNRLLLGTVALAAVLGTLYGLPQTRAHAEKPAAAAPTAVPVSVATVEPRDARLFETFSGRLEAVER
VEVRSRVAGAIKAIHFREGALVREGELLVSIDPEPFEAEVAEAEAQVAAAQARVELARNELERGQRLWTSRTVSQRDLDE
RVNGQRAAEAALRAVEAKLTSAKLSLSYTRVRAPVSGRVGKSEITVGNLVAAGPGAPVLTTLVSVDPIYASFNADEATVS
RALAGLGASADVSDQLDRIPVLMTTSAGGTPVEGHMQLVDNQVDVRTGTVRVRARFANADGRLLPGQFARLEMGQPVSEP
ALLVSERAVGTDQDKKFVFVVDAANTAVWREVTLGAPVDGLRVVTSGLKAGERIVVNGLHRVRPGAPVAPQSVPMRVTEA
APATLAN

Sequences:

>Translated_407_residues
MTAPISTAPRTARLRNRLLLGTVALAAVLGTLYGLPQTRAHAEKPAAAAPTAVPVSVATVEPRDARLFETFSGRLEAVER
VEVRSRVAGAIKAIHFREGALVREGELLVSIDPEPFEAEVAEAEAQVAAAQARVELARNELERGQRLWTSRTVSQRDLDE
RVNGQRAAEAALRAVEAKLTSAKLSLSYTRVRAPVSGRVGKSEITVGNLVAAGPGAPVLTTLVSVDPIYASFNADEATVS
RALAGLGASADVSDQLDRIPVLMTTSAGGTPVEGHMQLVDNQVDVRTGTVRVRARFANADGRLLPGQFARLEMGQPVSEP
ALLVSERAVGTDQDKKFVFVVDAANTAVWREVTLGAPVDGLRVVTSGLKAGERIVVNGLHRVRPGAPVAPQSVPMRVTEA
APATLAN
>Mature_406_residues
TAPISTAPRTARLRNRLLLGTVALAAVLGTLYGLPQTRAHAEKPAAAAPTAVPVSVATVEPRDARLFETFSGRLEAVERV
EVRSRVAGAIKAIHFREGALVREGELLVSIDPEPFEAEVAEAEAQVAAAQARVELARNELERGQRLWTSRTVSQRDLDER
VNGQRAAEAALRAVEAKLTSAKLSLSYTRVRAPVSGRVGKSEITVGNLVAAGPGAPVLTTLVSVDPIYASFNADEATVSR
ALAGLGASADVSDQLDRIPVLMTTSAGGTPVEGHMQLVDNQVDVRTGTVRVRARFANADGRLLPGQFARLEMGQPVSEPA
LLVSERAVGTDQDKKFVFVVDAANTAVWREVTLGAPVDGLRVVTSGLKAGERIVVNGLHRVRPGAPVAPQSVPMRVTEAA
PATLAN

Specific function: Unknown

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=338, Percent_Identity=33.7278106508876, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI1789929, Length=346, Percent_Identity=32.6589595375723, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786668, Length=382, Percent_Identity=33.2460732984293, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1789665, Length=364, Percent_Identity=30.4945054945055, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI87081796, Length=345, Percent_Identity=28.1159420289855, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87081951, Length=160, Percent_Identity=33.75, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42957; Mature: 42826

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPISTAPRTARLRNRLLLGTVALAAVLGTLYGLPQTRAHAEKPAAAAPTAVPVSVATV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEEEE
EPRDARLFETFSGRLEAVERVEVRSRVAGAIKAIHFREGALVREGELLVSIDPEPFEAEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCEEEEECCCCCHHHH
AEAEAQVAAAQARVELARNELERGQRLWTSRTVSQRDLDERVNGQRAAEAALRAVEAKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
SAKLSLSYTRVRAPVSGRVGKSEITVGNLVAAGPGAPVLTTLVSVDPIYASFNADEATVS
HHHEEEEEEEEECCCCCCCCCCCEEECCEEECCCCCHHHHHHHHCCCEEEECCCCHHHHH
RALAGLGASADVSDQLDRIPVLMTTSAGGTPVEGHMQLVDNQVDVRTGTVRVRARFANAD
HHHHHCCCCCCCHHHHHCCCEEEEECCCCCCCCCHHHHHCCCEEEEECEEEEEEEEECCC
GRLLPGQFARLEMGQPVSEPALLVSERAVGTDQDKKFVFVVDAANTAVWREVTLGAPVDG
CCCCCCHHHHEECCCCCCCCHHEEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCH
LRVVTSGLKAGERIVVNGLHRVRPGAPVAPQSVPMRVTEAAPATLAN
HHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure 
TAPISTAPRTARLRNRLLLGTVALAAVLGTLYGLPQTRAHAEKPAAAAPTAVPVSVATV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCEEEEEEE
EPRDARLFETFSGRLEAVERVEVRSRVAGAIKAIHFREGALVREGELLVSIDPEPFEAEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCEEEEECCCCCHHHH
AEAEAQVAAAQARVELARNELERGQRLWTSRTVSQRDLDERVNGQRAAEAALRAVEAKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
SAKLSLSYTRVRAPVSGRVGKSEITVGNLVAAGPGAPVLTTLVSVDPIYASFNADEATVS
HHHEEEEEEEEECCCCCCCCCCCEEECCEEECCCCCHHHHHHHHCCCEEEECCCCHHHHH
RALAGLGASADVSDQLDRIPVLMTTSAGGTPVEGHMQLVDNQVDVRTGTVRVRARFANAD
HHHHHCCCCCCCHHHHHCCCEEEEECCCCCCCCCHHHHHCCCEEEEECEEEEEEEEECCC
GRLLPGQFARLEMGQPVSEPALLVSERAVGTDQDKKFVFVVDAANTAVWREVTLGAPVDG
CCCCCCHHHHEECCCCCCCCHHEEECCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCH
LRVVTSGLKAGERIVVNGLHRVRPGAPVAPQSVPMRVTEAAPATLAN
HHHHHHHHCCCCEEEECCHHHCCCCCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA