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The map label for this gene is adk [H]

Identifier: 153952659

GI number: 153952659

Start: 1203290

End: 1203868

Strand: Direct

Name: adk [H]

Synonym: JJD26997_1360

Alternate gene names: 153952659

Gene position: 1203290-1203868 (Clockwise)

Preceding gene: 153951485

Following gene: 153951591

Centisome position: 65.22

GC content: 34.54

Gene sequence:

>579_bases
ATGAAAGAATTGTTTTTAATCATAGGTGCACCAGGTAGTGGAAAAACTACCGATGCTAGTTTAATCGCACAAGCAGATGC
GACAAATATCACACACTATTCAACAGGCGATCTTTTAAGAGCCCAAGTAGCAAGTGGGAGCGAACTTGGAAAAACTATAG
ATAGTTTTATCTCCAAAGGCAATCTTGTTCCTTTGGATGTGGTTGTAAATACTATAGTTTGTGCACTAAAAGCTGCTCCA
ACCAAAACTATTATCATCGATGGCTATCCAAGAAGTGTAGAGCAAATGATGGAATTTGACAAGGTTTTAAGTGAGCAAAA
TGAAATTTGTCTTAAAGGCGTCATAGAAGTAAGAGTAAGTGAAGAAGTTGCCAAAAAAAGAGTTCTAGGCAGAAATCGTG
GTGCAGATGATAATGAAGAAGTGTTTTACAATAGAATGAAAGTTTATACAGAACCTTTAAATGAAATTTTAGATTTTTAT
CAAAAGAAAAAACTTCATTTTATTATCGATGGAGAACGCACTATCGAACCTATCGTTGCAGACATGAAAGAGCTGATTAA
AAAAATTCAAAGCATATAA

Upstream 100 bases:

>100_bases
CAAAAACTCAAAGAGCGCAATGCTTAATGACAGAGGCTCCATCGCCTGCTAGCAATGAAGCAATGAGAGAGTTAGGAATC
AAATTAAGGGAGAATATAAA

Downstream 100 bases:

>100_bases
GGAGAAAAAATGGACTTAAGTAAAATCAAAATCGGAAATATTCCAAACAAAATCAATGCCGTAATCGAAATTCCATATGG
TTCAAACATAAAATACGAAA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKGNLVPLDVVVNTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERTIEPIVADMKELIKKIQSI

Sequences:

>Translated_192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKGNLVPLDVVVNTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERTIEPIVADMKELIKKIQSI
>Mature_192_residues
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKGNLVPLDVVVNTIVCALKAAP
TKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVSEEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFY
QKKKLHFIIDGERTIEPIVADMKELIKKIQSI

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=185, Percent_Identity=32.4324324324324, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=29.3269230769231, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI28144899, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI28144897, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI19923437, Length=206, Percent_Identity=29.126213592233, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=24.3523316062176, Blast_Score=74, Evalue=8e-14,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567503, Length=183, Percent_Identity=34.9726775956284, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=30.2325581395349, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=189, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17537943, Length=202, Percent_Identity=30.1980198019802, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=186, Percent_Identity=28.494623655914, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=210, Percent_Identity=28.0952380952381, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=27.3684210526316, Blast_Score=77, Evalue=1e-15,
Organism=Drosophila melanogaster, GI22026816, Length=199, Percent_Identity=29.6482412060301, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=31.0526315789474, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=31.0526315789474, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI221459597, Length=189, Percent_Identity=29.1005291005291, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21356893, Length=189, Percent_Identity=29.1005291005291, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17737899, Length=210, Percent_Identity=29.5238095238095, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24645822, Length=210, Percent_Identity=29.5238095238095, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21332; Mature: 21332

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKG
CCEEEEEEECCCCCCCCCHHHHEECCCCCCCEECCCHHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDVVVNTIVCALKAAPTKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFYQKKKLHFIIDGERTIEPIVA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
DMKELIKKIQSI
HHHHHHHHHHCC
>Mature Secondary Structure
MKELFLIIGAPGSGKTTDASLIAQADATNITHYSTGDLLRAQVASGSELGKTIDSFISKG
CCEEEEEEECCCCCCCCCHHHHEECCCCCCCEECCCHHHHHHHHCCHHHHHHHHHHHHCC
NLVPLDVVVNTIVCALKAAPTKTIIIDGYPRSVEQMMEFDKVLSEQNEICLKGVIEVRVS
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
EEVAKKRVLGRNRGADDNEEVFYNRMKVYTEPLNEILDFYQKKKLHFIIDGERTIEPIVA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHH
DMKELIKKIQSI
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA