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The map label for this gene is bioF [C]

Identifier: 153952135

GI number: 153952135

Start: 1466997

End: 1468139

Strand: Direct

Name: bioF [C]

Synonym: JJD26997_1659

Alternate gene names: 153952135

Gene position: 1466997-1468139 (Clockwise)

Preceding gene: 153952444

Following gene: 153951131

Centisome position: 79.51

GC content: 30.1

Gene sequence:

>1143_bases
ATGAAGCTTGAAAAAATTTTGCAAGATCTAGAGCAAAATCACAATCTAAGAACTCTAACGCCTTTAAAACATGAAAATAA
ATTTGTTTATAAGCAAGATCAAAAACTTTTAAATTTAGCAGGAAATGATTATCTTTATTTGGCGTCTTCTAAAGAGTTAA
AAGCTGAGTTTTTAAACACCTTAAAAGAACAAGATTTGTTTTTTTCAAGTTCGAGTTCAAGAAGTTTGAGTGGAAATTTT
GAAATTTATGAAGAATTAGAAAGTTTTTTAAAGACTAAATTTAAAAATAAGGAAATTTTGCATTTTAATAGTGGCTATCA
TCTAAATATCTCTTGTATAGCAGCACTTTCTAGCGTTTCTAAGACGCTTTTTTTAGCCGATAAACTCATTCATGCAAGTA
TGATTGATGGCTTAAGACTTGGCGGAGCTAATTTTTTTCGTTTTCATCATAAAGATATGAATCATTTAGAGAGTTTAATC
CAAAAACATTATGATAAATATGAAAATATCATCGTTTTAAGCGAAGCTTTGTTTAGTATGGATGGAGATTTTAGCGATTT
TAAAACTTTGTGTGAGCTTAAAAGGCGTTATGATAAAATCAAGCTTTATATAGATGAAGCACACAGCGTGGGTTGTTTTG
ATGAAGAGGGTTTGGGGCTTGTTAAAAAACTAGCCTTAGAAAATGAAGTGGATTTTTTGGTTTTTACCTTTGGAAAAGCC
TTTGCTTCCATGGGTGCTTGTATGATATGTGATGAAAAATATAAAAAATTTTTCATCAACAAAGCTAGAGCTTTTATTTA
TTCTACGGCCTTGCCACCTATTAATATAGCTTGGACGCAATTTATTTTTAAAAAAATGCCTTATTTTAAGAAAGAAAGAG
AAAAATTAGAACTTTTAAGTGCTTTTTTTAAAAGTAAATTGCAAGAAAAAAATCACACTGTTTTAGGCGATGTTTATATT
ATTTCCTTGCTTTTAGGTGAAAATAAAAAAGCCTTAGAAATTTCACAAAAACTCCAAAAAGCTGGTTTTTTTGCTCCTGC
GATCAAAGAACCTACCGTGCCAAAAAATACAGCCAGAATTCGTTTTTCTTTGCACGCAGGACTTAACACAGAAGAACTTG
AAAGGATAATAGAGCTTTTATGA

Upstream 100 bases:

>100_bases
TAAATCGAGATTTTTTAAGATTTGATTTTGCATTATAACTTCTTTTTTAAAAATATTTTGGCAAAATAATACTTTAAATT
TTTAAATTTACAGGAAAAAA

Downstream 100 bases:

>100_bases
AATATGAATTTTTATGTAAAAATCCTGATTCAAAAAAACTTATAGTGGTATTTGGGGGATTTGCTTCACATTCTAGTCAT
TTTTCGCATTTAAAAAGCGA

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKLEKILQDLEQNHNLRTLTPLKHENKFVYKQDQKLLNLAGNDYLYLASSKELKAEFLNTLKEQDLFFSSSSSRSLSGNF
EIYEELESFLKTKFKNKEILHFNSGYHLNISCIAALSSVSKTLFLADKLIHASMIDGLRLGGANFFRFHHKDMNHLESLI
QKHYDKYENIIVLSEALFSMDGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGKA
FASMGACMICDEKYKKFFINKARAFIYSTALPPINIAWTQFIFKKMPYFKKEREKLELLSAFFKSKLQEKNHTVLGDVYI
ISLLLGENKKALEISQKLQKAGFFAPAIKEPTVPKNTARIRFSLHAGLNTEELERIIELL

Sequences:

>Translated_380_residues
MKLEKILQDLEQNHNLRTLTPLKHENKFVYKQDQKLLNLAGNDYLYLASSKELKAEFLNTLKEQDLFFSSSSSRSLSGNF
EIYEELESFLKTKFKNKEILHFNSGYHLNISCIAALSSVSKTLFLADKLIHASMIDGLRLGGANFFRFHHKDMNHLESLI
QKHYDKYENIIVLSEALFSMDGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGKA
FASMGACMICDEKYKKFFINKARAFIYSTALPPINIAWTQFIFKKMPYFKKEREKLELLSAFFKSKLQEKNHTVLGDVYI
ISLLLGENKKALEISQKLQKAGFFAPAIKEPTVPKNTARIRFSLHAGLNTEELERIIELL
>Mature_380_residues
MKLEKILQDLEQNHNLRTLTPLKHENKFVYKQDQKLLNLAGNDYLYLASSKELKAEFLNTLKEQDLFFSSSSSRSLSGNF
EIYEELESFLKTKFKNKEILHFNSGYHLNISCIAALSSVSKTLFLADKLIHASMIDGLRLGGANFFRFHHKDMNHLESLI
QKHYDKYENIIVLSEALFSMDGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGKA
FASMGACMICDEKYKKFFINKARAFIYSTALPPINIAWTQFIFKKMPYFKKEREKLELLSAFFKSKLQEKNHTVLGDVYI
ISLLLGENKKALEISQKLQKAGFFAPAIKEPTVPKNTARIRFSLHAGLNTEELERIIELL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=365, Percent_Identity=27.6712328767123, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI284448556, Length=363, Percent_Identity=27.8236914600551, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI83977442, Length=349, Percent_Identity=26.0744985673352, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI83977440, Length=349, Percent_Identity=26.0744985673352, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI83977444, Length=349, Percent_Identity=26.0744985673352, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI119220554, Length=374, Percent_Identity=26.2032085561497, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4758668, Length=362, Percent_Identity=26.5193370165746, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4502025, Length=327, Percent_Identity=24.7706422018349, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI40316939, Length=327, Percent_Identity=24.7706422018349, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI5454084, Length=254, Percent_Identity=24.8031496062992, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786993, Length=363, Percent_Identity=29.4765840220386, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790046, Length=346, Percent_Identity=26.3005780346821, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71994529, Length=354, Percent_Identity=27.1186440677966, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=25.4794520547945, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=387, Percent_Identity=24.031007751938, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17560912, Length=387, Percent_Identity=24.031007751938, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71982617, Length=288, Percent_Identity=22.9166666666667, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71982625, Length=288, Percent_Identity=22.9166666666667, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320267, Length=364, Percent_Identity=28.2967032967033, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320438, Length=382, Percent_Identity=26.4397905759162, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323954, Length=275, Percent_Identity=23.2727272727273, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24662918, Length=363, Percent_Identity=26.1707988980716, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI17136286, Length=371, Percent_Identity=27.4932614555256, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17137420, Length=348, Percent_Identity=25.8620689655172, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653280, Length=313, Percent_Identity=22.3642172523962, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24653276, Length=313, Percent_Identity=22.3642172523962, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24653278, Length=313, Percent_Identity=22.3642172523962, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43902; Mature: 43902

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLEKILQDLEQNHNLRTLTPLKHENKFVYKQDQKLLNLAGNDYLYLASSKELKAEFLNT
CCHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
LKEQDLFFSSSSSRSLSGNFEIYEELESFLKTKFKNKEILHFNSGYHLNISCIAALSSVS
HHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHH
KTLFLADKLIHASMIDGLRLGGANFFRFHHKDMNHLESLIQKHYDKYENIIVLSEALFSM
HHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHC
DGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGKA
CCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHH
FASMGACMICDEKYKKFFINKARAFIYSTALPPINIAWTQFIFKKMPYFKKEREKLELLS
HHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
AFFKSKLQEKNHTVLGDVYIISLLLGENKKALEISQKLQKAGFFAPAIKEPTVPKNTARI
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
RFSLHAGLNTEELERIIELL
EEEEECCCCHHHHHHHHHHC
>Mature Secondary Structure
MKLEKILQDLEQNHNLRTLTPLKHENKFVYKQDQKLLNLAGNDYLYLASSKELKAEFLNT
CCHHHHHHHHHHCCCCEEECCCCCCCCEEEHHHHHHHHHCCCCEEEEECCHHHHHHHHHH
LKEQDLFFSSSSSRSLSGNFEIYEELESFLKTKFKNKEILHFNSGYHLNISCIAALSSVS
HHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHH
KTLFLADKLIHASMIDGLRLGGANFFRFHHKDMNHLESLIQKHYDKYENIIVLSEALFSM
HHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHC
DGDFSDFKTLCELKRRYDKIKLYIDEAHSVGCFDEEGLGLVKKLALENEVDFLVFTFGKA
CCCHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCEEEEHHHHH
FASMGACMICDEKYKKFFINKARAFIYSTALPPINIAWTQFIFKKMPYFKKEREKLELLS
HHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
AFFKSKLQEKNHTVLGDVYIISLLLGENKKALEISQKLQKAGFFAPAIKEPTVPKNTARI
HHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
RFSLHAGLNTEELERIIELL
EEEEECCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA