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The map label for this gene is ilvD [H]

Identifier: 153952083

GI number: 153952083

Start: 17988

End: 19664

Strand: Direct

Name: ilvD [H]

Synonym: JJD26997_0013

Alternate gene names: 153952083

Gene position: 17988-19664 (Clockwise)

Preceding gene: 153951673

Following gene: 153950993

Centisome position: 0.97

GC content: 37.45

Gene sequence:

>1677_bases
ATGAGAAGCGATGCGATAAAAAAAGGACATTTAAAAGCACCTAATCGTTCTTTACTTCGTGCTTGTGGTTTGAAAGATGA
AGATTTTGACAAACCTTTTATAGGTGTAGCAAATAGCTATATAGACATAATTCCAGGGCATTATTTTTTAAATGATTATG
CTAAAATCATTAAAGATGAAATACGCAAAAATGGTTGCGTGCCTTTTGAGTTTAATACCATAGGTATAGATGATGGTATA
GCTATGGGGCATGAAGGTATGCTTTATTCTTTACCCAGTCGTGAAATCATCGCAAATTCTATTGAAACAGTGATGAATGC
TCATCAACTTGATGCTTTAATCTGTATTCCAAACTGCGATAAAATCACTCCTGGTATGTTAATGGGAGCTTTAAGGGTAA
ATGTTCCAACCATTTTTGTAAGTGGTGGACCTATGGCTTCAGGAGTAACCAAAAAAGGAGAAAAGATCAGTCTTAGCTCT
GTTTTTGAAGCCGTAGGGGCTTATGAAGCCAAAAAAATTAGCGAAGAAGAATTTAAAGATATAGAATGTTCAGCCTGTCC
AAGTGGTGGATCTTGTTCAGGAATGTTTACAGCAAATTCTATGAATACCTTATGCGAAGCTATGGGTATAGCACTAGAAG
GCAATGGAACCATTTTAGCTTTAAGCAAAGAAAGAGAAGAGCTTTTAAGAAAAGCAGCGCGTCGTATTTGTGAAATCGCC
TTAGATGAGCGTTTTAAAATTCGCAATATCATCACTCAAAAAGCCGTGCGTAATGCCATGATAGTAGATATGGCAATGGG
TGGAAGTAGCAATACAGTTTTACACATGCTTGCCATTTCGCGTGAAGCAGGGGTAGCACTAGACATTAAAGACTTAAATT
TCATCTCAAGTAAAGTCGCACACATAGCAAAAATAGCCCCATCGCTAAATAGTGTTTATATGGATGATATCCACAAAGCA
GGGGGTGTAAGTGCAGTTATGGCTGAAATTTCAAGCAGACAAGGACATATTTTAGAACTTGATGCACTAACTATCACAGG
AGAAAGTCTCGAAGAACGCTTAAAAAATGCCAAAATCAAAGATGAAAATATCATTCGCAAAGTAGATAATGCTTACTCAA
AAGTAGGCGGGCTTGCCATTTTGTTTGGAAATTTAGCCGAGCAAGGTTGTGTTATAAAAACCGCAGGAATAATCGGAGAA
AGAAAATTTAAAGGCAAAGCTGTTTGTTTTAACTCTCAAGATGAAGCTATAAAAGGCATTATTAAAGGCAAGGTGCAAAA
AGGAAATGTTTGCGTGATACGCTATGAAGGTCCAAAAGGTGGCCCTGGTATGCAAGAAATGTTAAGCCCTACTTCACTTT
TAATGGGTATGGGTTTGGGTGCTGATGTGGCTTTAATCACCGATGGTCGTTTTAGTGGGGCTACAAGGGGTTTAAGTATA
GGTCATATTTCCCCTGAAGCAGCTGAAGGTGGTCTTATAGGACTTTTAAAAGATGGAGATGAAATAGAAATTGATGTAGA
TGCTTATACTATCCATGCAAATTTAAGCGAAAAAGAAATCACTCAACGCAAAAAAGAATTTGTATTGCCTCAAAAAGAAG
TGCCTTCAAGATGGCTTAGAATGTATCAAAAACTTGTTAGCAACGCTAGTAAAGGTGCGGTTTTGGATATGGAATGA

Upstream 100 bases:

>100_bases
TAATAATTTTTATTATTTATGAAAATGTATATCAAAATAAATTTCACAAAAATTAAGCTTTGCTAAATATAATTTTAAAA
AATTATTATCAGGAGTTACA

Downstream 100 bases:

>100_bases
AAGGAAACCTTTCATTCTTCTATTTCTTTGGTTATACGATTTTTTATATCTCTATGAACTATTTCCATACCCCACAGCCA
AACAATATGGCCAAAAATTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 558; Mature: 558

Protein sequence:

>558_residues
MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDEIRKNGCVPFEFNTIGIDDGI
AMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCDKITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSS
VFEAVGAYEAKKISEEEFKDIECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIA
LDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVAHIAKIAPSLNSVYMDDIHKA
GGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIKDENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGE
RKFKGKAVCFNSQDEAIKGIIKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSI
GHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLRMYQKLVSNASKGAVLDME

Sequences:

>Translated_558_residues
MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDEIRKNGCVPFEFNTIGIDDGI
AMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCDKITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSS
VFEAVGAYEAKKISEEEFKDIECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIA
LDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVAHIAKIAPSLNSVYMDDIHKA
GGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIKDENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGE
RKFKGKAVCFNSQDEAIKGIIKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSI
GHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLRMYQKLVSNASKGAVLDME
>Mature_558_residues
MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDEIRKNGCVPFEFNTIGIDDGI
AMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCDKITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSS
VFEAVGAYEAKKISEEEFKDIECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIA
LDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVAHIAKIAPSLNSVYMDDIHKA
GGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIKDENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGE
RKFKGKAVCFNSQDEAIKGIIKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSI
GHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLRMYQKLVSNASKGAVLDME

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=608, Percent_Identity=46.3815789473684, Blast_Score=521, Evalue=1e-149,
Organism=Escherichia coli, GI1788157, Length=515, Percent_Identity=29.3203883495146, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1786464, Length=505, Percent_Identity=32.0792079207921, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI2367371, Length=570, Percent_Identity=31.2280701754386, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6322476, Length=551, Percent_Identity=42.4682395644283, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60187; Mature: 60187

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDE
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCEECCCHHHHHHHHHHHHHH
IRKNGCVPFEFNTIGIDDGIAMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCD
HHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCC
KITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSSVFEAVGAYEAKKISEEEFKD
CCCHHHHHHHEEECCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHCCHHHHCC
IECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCEEEECCCEEEEECHHHHHHHHHHHHHHHHHH
LDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVA
HCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHH
HIAKIAPSLNSVYMDDIHKAGGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIK
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHCCCCC
DENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGERKFKGKAVCFNSQDEAIKGI
CHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEECCHHHHHHHH
IKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSI
HHCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLR
CCCCCCCCCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCHHCCHHHHH
MYQKLVSNASKGAVLDME
HHHHHHCCCCCCCEEECC
>Mature Secondary Structure
MRSDAIKKGHLKAPNRSLLRACGLKDEDFDKPFIGVANSYIDIIPGHYFLNDYAKIIKDE
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCEECCCHHHHHHHHHHHHHH
IRKNGCVPFEFNTIGIDDGIAMGHEGMLYSLPSREIIANSIETVMNAHQLDALICIPNCD
HHHCCCCEEEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCC
KITPGMLMGALRVNVPTIFVSGGPMASGVTKKGEKISLSSVFEAVGAYEAKKISEEEFKD
CCCHHHHHHHEEECCCEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCHHHHHCCHHHHCC
IECSACPSGGSCSGMFTANSMNTLCEAMGIALEGNGTILALSKEREELLRKAARRICEIA
CCCCCCCCCCCCCEEEECCHHHHHHHHHCEEEECCCEEEEECHHHHHHHHHHHHHHHHHH
LDERFKIRNIITQKAVRNAMIVDMAMGGSSNTVLHMLAISREAGVALDIKDLNFISSKVA
HCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCEEEEEEECCCCCCEEEEHHHHHHHHHHH
HIAKIAPSLNSVYMDDIHKAGGVSAVMAEISSRQGHILELDALTITGESLEERLKNAKIK
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHCCCCC
DENIIRKVDNAYSKVGGLAILFGNLAEQGCVIKTAGIIGERKFKGKAVCFNSQDEAIKGI
CHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEECCCCCCCCCCCCEEEECCHHHHHHHH
IKGKVQKGNVCVIRYEGPKGGPGMQEMLSPTSLLMGMGLGADVALITDGRFSGATRGLSI
HHCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEE
GHISPEAAEGGLIGLLKDGDEIEIDVDAYTIHANLSEKEITQRKKEFVLPQKEVPSRWLR
CCCCCCCCCCCEEEEEECCCEEEEEEEEEEEEECCCHHHHHHHHHHHCCCCHHCCHHHHH
MYQKLVSNASKGAVLDME
HHHHHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA