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The map label for this gene is hemH [H]

Identifier: 153951990

GI number: 153951990

Start: 1272594

End: 1273505

Strand: Direct

Name: hemH [H]

Synonym: JJD26997_1433

Alternate gene names: 153951990

Gene position: 1272594-1273505 (Clockwise)

Preceding gene: 153951743

Following gene: 153951454

Centisome position: 68.97

GC content: 27.74

Gene sequence:

>912_bases
GTGAGATTAGTTTTATTTTTAAATATGGGCGGAGCTATGAATTTACAAGATTGTGAAGTTTTTTTAAAAAATATGTTTAA
TGATCCTTATATTTTAGGAATCAAAAATCGATTTTTAAGAAAATTTGTAGCGTGGATCATAACAAAAGCTCGCGTTAAAG
CCATGCAAGAAAACTATAAAAAAATGGGCGGAAAATCCCCTTTAAACGAACTTACTCAAAGCCTGTGTGACAAGCTTAAT
TTAAAACAAGATGAATTTAAATTTGATTTTGTAAATCTTTATGTACCTCCTTTTGCCACAGAAATTTTGCAAAAATACAC
TTTAAATGAAAATGATGAAATCATTCTTTTTCCACTTTATCCACACCATTCTTGCACCACAGTAACTTCATCTTTAGAAA
TTCTGCAAGATGAAATTTCAAAGCAAAAAATTCAAGCAAAAGTAAAAACTATAGATATTTTTTACAAAAATAAACTTTAT
AATGAGATGATAGTTTCGCACATTTTGGCTAAAAAAAATAAATTTGATGCCAAAATTTTGATTTTTTCAGCGCATTCTTT
ACCACAAAGCATTATTGATAAGGGTGATTTATACGAAAAGCATGTAAAGGATCATGTAGAAATTTTAAAAGAAAAATTAA
AAGATCATTTTGATGAATTTATTTTAGCTTATCAGTCTAAACTAGGCCCTGTAAAATGGCTTGAACCAAATACAAGCGAT
GTTTTAGCAAATTTAAACGATAAAGCTTTGATTTATCCTATTTCTTTTTGCATTGATTGTTCTGAAACGATTTTTGAACT
AGGTATGGAGTATAAACATTTAGCAAAATGTGATTATGATTTGATAAGTTGCCCTAATGATAGTGATGAATTTGCCCAAT
TTATTTTAAAGTATTTATCTGATCTTAACTAA

Upstream 100 bases:

>100_bases
GAGAACATGAAGCTTTGTTAAAACTTATCGATAATCAACCCAATCATTTAGCCAGCACAAGCGATGCTTACAAAGTTCAA
GAAATTTTAGAAAGGTTTGC

Downstream 100 bases:

>100_bases
GAATGAATTTAAACCCTGCTACAAGCCCACTAAGTCCACCTAAAATAGTCGGTTTTTTATGGATGATCCACTCAAGCACT
ACCCATTGTAAAGTAATGAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MRLVLFLNMGGAMNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNENDEIILFPLYPHHSCTTVTSSLEILQDEISKQKIQAKVKTIDIFYKNKLY
NEMIVSHILAKKNKFDAKILIFSAHSLPQSIIDKGDLYEKHVKDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNDSDEFAQFILKYLSDLN

Sequences:

>Translated_303_residues
MRLVLFLNMGGAMNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNENDEIILFPLYPHHSCTTVTSSLEILQDEISKQKIQAKVKTIDIFYKNKLY
NEMIVSHILAKKNKFDAKILIFSAHSLPQSIIDKGDLYEKHVKDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNDSDEFAQFILKYLSDLN
>Mature_303_residues
MRLVLFLNMGGAMNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYKKMGGKSPLNELTQSLCDKLN
LKQDEFKFDFVNLYVPPFATEILQKYTLNENDEIILFPLYPHHSCTTVTSSLEILQDEISKQKIQAKVKTIDIFYKNKLY
NEMIVSHILAKKNKFDAKILIFSAHSLPQSIIDKGDLYEKHVKDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNDSDEFAQFILKYLSDLN

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=291, Percent_Identity=31.6151202749141, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI60499025, Length=291, Percent_Identity=31.6151202749141, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1786681, Length=274, Percent_Identity=22.6277372262774, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324750, Length=283, Percent_Identity=27.5618374558304, Blast_Score=102, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17864156, Length=321, Percent_Identity=26.4797507788162, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24651774, Length=257, Percent_Identity=26.8482490272374, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45552018, Length=132, Percent_Identity=29.5454545454545, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 35264; Mature: 35264

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLFLNMGGAMNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYK
CEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMGGKSPLNELTQSLCDKLNLKQDEFKFDFVNLYVPPFATEILQKYTLNENDEIILFPLY
HCCCCCCHHHHHHHHHHHCCCCCHHCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECC
PHHSCTTVTSSLEILQDEISKQKIQAKVKTIDIFYKNKLYNEMIVSHILAKKNKFDAKIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IFSAHSLPQSIIDKGDLYEKHVKDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
EEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNDSDEFAQFILKYLS
HHHCCCCCEEEEEHHHHHCCHHHHHHHCCHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
DLN
CCC
>Mature Secondary Structure
MRLVLFLNMGGAMNLQDCEVFLKNMFNDPYILGIKNRFLRKFVAWIITKARVKAMQENYK
CEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
KMGGKSPLNELTQSLCDKLNLKQDEFKFDFVNLYVPPFATEILQKYTLNENDEIILFPLY
HCCCCCCHHHHHHHHHHHCCCCCHHCEEEEEEEECCHHHHHHHHHHCCCCCCCEEEEECC
PHHSCTTVTSSLEILQDEISKQKIQAKVKTIDIFYKNKLYNEMIVSHILAKKNKFDAKIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
IFSAHSLPQSIIDKGDLYEKHVKDHVEILKEKLKDHFDEFILAYQSKLGPVKWLEPNTSD
EEECCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHH
VLANLNDKALIYPISFCIDCSETIFELGMEYKHLAKCDYDLISCPNDSDEFAQFILKYLS
HHHCCCCCEEEEEHHHHHCCHHHHHHHCCHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
DLN
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA