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The map label for this gene is thiD [H]

Identifier: 153951985

GI number: 153951985

Start: 584454

End: 585266

Strand: Direct

Name: thiD [H]

Synonym: JJD26997_0641

Alternate gene names: 153951985

Gene position: 584454-585266 (Clockwise)

Preceding gene: 153952148

Following gene: 153951222

Centisome position: 31.68

GC content: 35.79

Gene sequence:

>813_bases
ATGAAAGCAAAAGGAAGTGAACTTATACCTGTTTTAACTATAGCAGGGAGTGATTGTAGTGGTGGAGCAGGGATACAAGC
CGATCTTAAAACCTTTAGTGCACACAATCTTTTTGGTATGAGTGTGGTTTTAAGTGTGGTAGCTGAAAATACCGCAAGGG
TGATTTCTGTACACGATATACCTACTCAAAGCGTGGATGAACAAATGCTTGCCGTGTTTGAAGATATAGTGCCAAAGGCA
ACTAAAATTGGAATGATAGGATCTTGTGAATTAATGAGCTGTGTAGCTAAAAATTTAAGCGAGTTTAAACCTCAAAATGT
AGTGATTGATCCTGTAATGTTTGCTAAAAATGGCTATGCTTTAATGCCGCAAGAAAATTGTGATTTTTTCAAACAAACCA
TAGTAAAATTTGCAGACATTCTTACGCCTAATATACCTGAAGCAGAGTTTTTATGCGGTTTTAAGATTGCTAATGAAGAG
CAGATGATAAAGGCAGCTAAGCATTTATGTAGCTTGGGGGCTAAGGCTGTTTTGCTTAAAGGTGGGCATAGTGAAGAAAA
TGCCAATGATGTGCTTTACGATGGAAAAGAAATTTATATTTTAAAAGGCGAACGCATAGAAACTAAAAATACTCACGGTA
CAGGTTGTACGCTTTCTTCGGCTATTGCTAGTAATTTAGCTAAAGGCAAGGATTTATTTCATGCCGTTAGTGAAGCTAAA
GAATATGTAAGAAATGCGATTTATTATTCACTCAATCTTGGAAAAGGTTGTGGTCCTACAAATCATTTTTTCAAGTTTTT
AGATGAAAAATAA

Upstream 100 bases:

>100_bases
TTTTTCATGCTTTGATTGTAGCTTTTGCAAAACAGAGTTTTAAAGGACAAAAATTAAGCCCTAAGGGTGAAGAATGGATC
AAAATTTTAAAGGAAGATTT

Downstream 100 bases:

>100_bases
ATTAGATCTTAGTCTTTATCTAGTTGCTACTAAGGGAAATAAAAGCGAGGAGTGTTTTTTAAACACTTTAGAAAATGCTA
TAAAAGGCGGAGTAAGTATA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGAKAVLLKGGHSEENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK

Sequences:

>Translated_270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGAKAVLLKGGHSEENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
>Mature_270_residues
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDIPTQSVDEQMLAVFEDIVPKA
TKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYALMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFKIANEE
QMIKAAKHLCSLGAKAVLLKGGHSEENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=41.06463878327, Blast_Score=194, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6325378, Length=278, Percent_Identity=36.3309352517986, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6324997, Length=279, Percent_Identity=36.9175627240143, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=36.7272727272727, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29217; Mature: 29217

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDI
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECC
PTQSVDEQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYA
CCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEECCCCEE
LMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFKIANEEQMIKAAKHLCSLGAKAVLLK
ECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECEEECCHHHHHHHHHHHHHCCCCEEEEE
GGHSEENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
CCCCCCCCCCEEECCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
HHHHHHHEEEEECCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKAKGSELIPVLTIAGSDCSGGAGIQADLKTFSAHNLFGMSVVLSVVAENTARVISVHDI
CCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECC
PTQSVDEQMLAVFEDIVPKATKIGMIGSCELMSCVAKNLSEFKPQNVVIDPVMFAKNGYA
CCCHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHHCCCCCEEECCEEECCCCEE
LMPQENCDFFKQTIVKFADILTPNIPEAEFLCGFKIANEEQMIKAAKHLCSLGAKAVLLK
ECCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECEEECCHHHHHHHHHHHHHCCCCEEEEE
GGHSEENANDVLYDGKEIYILKGERIETKNTHGTGCTLSSAIASNLAKGKDLFHAVSEAK
CCCCCCCCCCEEECCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EYVRNAIYYSLNLGKGCGPTNHFFKFLDEK
HHHHHHHEEEEECCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]