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The map label for this gene is argH [H]

Identifier: 153951734

GI number: 153951734

Start: 784358

End: 785740

Strand: Direct

Name: argH [H]

Synonym: JJD26997_0883

Alternate gene names: 153951734

Gene position: 784358-785740 (Clockwise)

Preceding gene: 153951612

Following gene: 153951413

Centisome position: 42.51

GC content: 31.6

Gene sequence:

>1383_bases
ATGAAAAATGAAATGTGGTCAGGACGCTTTAGCGGTGCAAGTGATGAGCTTCTAAAGGAATTTAATGCGAGTTTGAATGT
AGATAAAACTTTGTTTAATGAAGATATACAAGGATCTATAGCACACGCTACAATGCTTGAAAGTTGTGGTATTTTAAAAA
AAGAAGAATTAGATGCTATTGTAAAAGGCTTAGAGCAGGTTAGAAGTGAAATAGAGCAAGGCAAATTTATTTTTGATATT
AAAGATGAAGATATTCATATGGCTATAGAAAAGCGTTTGAGTGAAATTATAGGCAGTGAAATTGGTGGAAGACTACATAC
CGCAAGAAGTAGAAATGACCAAGTGGCTACTGATTTTAAACTTTTTGTCAAAAAATCTCATATTGAACTTATAAAGCTTT
TAAAAGAATTGATTCAAACCATGCTTGAACATGCTAAAGTGCATAAAAAAACTATTATGCCAAGTTTTACACATTTACAA
CATGCTCAGCCTGTGAGTTTTTCTTTTTATATTTTAGCTTATGCTTTTATGTTAATGCGAGATGTTAAGCGTTTGCAAAA
TAGTCTAGAACTTGCAGGCTTTTCGCCACTTGGATCTTGTGCATGTGCAGGAACAAGCTATGCTACCAATCGTGAGTTGA
GTGCTAAAATTTTAGGATTTAAGGATATTATGCCAAATGCTATGGATGGAGTGAGTGATAGGGATTTTGTTCTTGATTTA
CTTTATGATATAGCAGTTATTTTTACACATACTTCAAGACTTTGCGAGGAAATGATTTTATTTTCAAGCTCGGAGTTTTC
TTTTATAACTATAAGTGATAGTTTTTCAACAGGAAGTTCTATCATGCCTCAGAAAAAAAATCCCGATGTTTGCGAACTTA
TACGTGGAAAAACAGGGCGTGTTTATGGAAATTTGATTTCTCTTTTAACCATAATGAAAGCTTTACCTTTGGCCTACAAT
AAAGATATGCAAGAAGATAAAGAAGGGCTTTTTGATAGTGTAAAAACCGCTAAAGATAGTTTAATCATCTTAAATGTAAT
GCTAAAAGAAATACGAATTAATAAAGAAAATATGCTTAATGCTTGCAAAAAAGGTCATTTGTTAGCTACTGATTTGGCGG
ATTATTTAGTGCGTGAAAAAAATATTCCTTTTAGAAAAGCACATTTTATAGTGGGAAATGTTGTTGCACAAGCCGAAGTA
CAAGGCATTGATATAAGCGAAATTAAAGATCTTTCAAAAATAGATCCTATATTTGATGAAAAAGCTATGGAGCTTTTAAA
TTTTGAATTTTCTTTAAATTCTAAGCAAAGCGAAGGCTCAAGTTCTATTGCAAGCGTAGAAAAGCAAATTCAAATTTTAC
AAGAATTTATTAAAAAATTATAA

Upstream 100 bases:

>100_bases
TAAATTAGCCCATATGTTTGTGCAAAATTTTAAACGCTATGAAGATGTCAAAGAAGGCATTGAATTTAGCAAATTTGGAC
CAAAAATTTAAGGCGTTTAA

Downstream 100 bases:

>100_bases
ATATTGTTTAAGCTATTTTGCCTAAACATTGAATCTAAAATGCATTATATCACCATCTAAAACGATATAGTCTTTTCCTT
CAAGGCGCAGTTTTCCTGCT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIVKGLEQVRSEIEQGKFIFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLEHAKVHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDVKRLQNSLELAGFSPLGSCACAGTSYATNRELSAKILGFKDIMPNAMDGVSDRDFVLDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGLFDSVKTAKDSLIILNVMLKEIRINKENMLNACKKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEV
QGIDISEIKDLSKIDPIFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILQEFIKKL

Sequences:

>Translated_460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIVKGLEQVRSEIEQGKFIFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLEHAKVHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDVKRLQNSLELAGFSPLGSCACAGTSYATNRELSAKILGFKDIMPNAMDGVSDRDFVLDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGLFDSVKTAKDSLIILNVMLKEIRINKENMLNACKKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEV
QGIDISEIKDLSKIDPIFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILQEFIKKL
>Mature_460_residues
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAIVKGLEQVRSEIEQGKFIFDI
KDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFKLFVKKSHIELIKLLKELIQTMLEHAKVHKKTIMPSFTHLQ
HAQPVSFSFYILAYAFMLMRDVKRLQNSLELAGFSPLGSCACAGTSYATNRELSAKILGFKDIMPNAMDGVSDRDFVLDL
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGRVYGNLISLLTIMKALPLAYN
KDMQEDKEGLFDSVKTAKDSLIILNVMLKEIRINKENMLNACKKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEV
QGIDISEIKDLSKIDPIFDEKAMELLNFEFSLNSKQSEGSSSIASVEKQIQILQEFIKKL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=458, Percent_Identity=42.5764192139738, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI68303542, Length=458, Percent_Identity=42.5764192139738, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI68303549, Length=458, Percent_Identity=40.6113537117904, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI68303547, Length=458, Percent_Identity=40.3930131004367, Blast_Score=353, Evalue=2e-97,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=43.421052631579, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6321806, Length=455, Percent_Identity=41.5384615384615, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI221473854, Length=459, Percent_Identity=39.6514161220044, Blast_Score=348, Evalue=5e-96,
Organism=Drosophila melanogaster, GI78706858, Length=459, Percent_Identity=39.6514161220044, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 51788; Mature: 51788

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAI
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
VKGLEQVRSEIEQGKFIFDIKDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFK
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
LFVKKSHIELIKLLKELIQTMLEHAKVHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
DVKRLQNSLELAGFSPLGSCACAGTSYATNRELSAKILGFKDIMPNAMDGVSDRDFVLDL
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCHHHHCCCHHCCCCCHHHHHHH
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGNLISLLTIMKALPLAYNKDMQEDKEGLFDSVKTAKDSLIILNVMLKEIRINKENMLN
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
ACKKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEVQGIDISEIKDLSKIDPIFDE
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KAMELLNFEFSLNSKQSEGSSSIASVEKQIQILQEFIKKL
HHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKNEMWSGRFSGASDELLKEFNASLNVDKTLFNEDIQGSIAHATMLESCGILKKEELDAI
CCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHH
VKGLEQVRSEIEQGKFIFDIKDEDIHMAIEKRLSEIIGSEIGGRLHTARSRNDQVATDFK
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHH
LFVKKSHIELIKLLKELIQTMLEHAKVHKKTIMPSFTHLQHAQPVSFSFYILAYAFMLMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHH
DVKRLQNSLELAGFSPLGSCACAGTSYATNRELSAKILGFKDIMPNAMDGVSDRDFVLDL
HHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHCHHHHCCCHHCCCCCHHHHHHH
LYDIAVIFTHTSRLCEEMILFSSSEFSFITISDSFSTGSSIMPQKKNPDVCELIRGKTGR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCCCH
VYGNLISLLTIMKALPLAYNKDMQEDKEGLFDSVKTAKDSLIILNVMLKEIRINKENMLN
HHHHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHH
ACKKGHLLATDLADYLVREKNIPFRKAHFIVGNVVAQAEVQGIDISEIKDLSKIDPIFDE
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHH
KAMELLNFEFSLNSKQSEGSSSIASVEKQIQILQEFIKKL
HHHHHHHCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA