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The map label for this gene is cmeA [H]

Identifier: 153951714

GI number: 153951714

Start: 1405392

End: 1406495

Strand: Direct

Name: cmeA [H]

Synonym: JJD26997_1590

Alternate gene names: 153951714

Gene position: 1405392-1406495 (Clockwise)

Preceding gene: 153952460

Following gene: 153950964

Centisome position: 76.17

GC content: 32.43

Gene sequence:

>1104_bases
ATGAAATTATTTCAAAAAAATACTATTTTAGTTTTAGGTGTTGTGTTTTTACTCACTGCTTGCAGCAAAGAAGAAGCGCC
AAAAATACAAATGCCGCCTCAACCTGTAACAACCATGAGTGCTAAATCTGAAGATTTACCACTTAATTTTACCTATCCTG
CCAAACTTGTCAGTGATTATGATGTTATTATAAAACCTCAAGTTAGCGGTGTGATAGTAAATAAACTTTTTAAGGCTGGA
GATAAGGTAAAAAGAGGACAAACATTATTTATTATAGAACAAGCCAAATTTAAAGCTAGCGTTGATTCAGCCTACGGACA
AGCGTTAATGGCTAAAGCAACTTTCGAAAATGCAAGTAAAGATTTTAATCGCTCTGAGGCTCTTTTTAGCAAAAACGCAA
TCTCTCAAAAAGAATACGACTCTTCTCTTGCTACATTTAATAATGCAAAAGCTAGTCTAGCAAGTGCTAGAGCACAGCTT
GCAAATGCAAGAATTGATCTAGATCATACCGAAATAAAAGCTCCTTTTGATGGTACTATAGGAGATGCTTTAGTTAATAT
AGGAGATTATGTAAGCACTTCAACAACTGAACTAGTTAGAGTTACAAATTTAAATCCTATTTACGCAGATTTCTTTATTT
CAGATACAGATAAACTAAATTTAGTCCGCAATACTCAAAGTGGAAAATGGGATTTAGACAGCATTCATGCAAATTTAAAT
CTTAACGGAGAAACTGTTCAAGGCAAACTTTATTTTATTGATTCTGTTATAGATGCCAATAGTGGAACAGTAAAAGCCAA
AGCTGTATTTGATAACAACAACTCGACACTTTTACCAGGTGCTTTTGCAACGATTACCTCAGAAGGTTTTATACAAAAAA
ATGGCTTTAAGGTACCTCAAATAGCTATTAAACAAGATCAAAATGATGTTTATGTTCTTCTTGTTAAAAATGGAAAAGTA
GAAAAATCTTCTGTACATATAAGCTACCAAAACAATGAATACGCTATTATTGACAAAGGATTGCAAAATGGCGATAAAAT
CATTTTGGATAATTTTAAAAAAATTCAAGTTGGTAGCGAAGTTAAAGAAATTGGAGCACAATAA

Upstream 100 bases:

>100_bases
GCTTAAAAAATAATTTTATTAACCAAAATTAAGATATAATTAGCCAAAAATTTTTGTAATAAATATTACAATTTTTAATT
TAATTTTTCAAGGCAAAATC

Downstream 100 bases:

>100_bases
TGTTTTCTAAATTTTTTATCGAAAGACCTGTTTTTGCCTCAGTTGTTGCAATTATCATTTCTTTAGCTGGAGTCATAGGT
CTTACAAATTTACCTATAGA

Product: RND efflux system, membrane fusion protein CmeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAG
DKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQL
ANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLN
LNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKV
EKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVKEIGAQ

Sequences:

>Translated_367_residues
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAG
DKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQL
ANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLN
LNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKV
EKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVKEIGAQ
>Mature_367_residues
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDYDVIIKPQVSGVIVNKLFKAG
DKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASKDFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQL
ANARIDLDHTEIKAPFDGTIGDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLN
LNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQIAIKQDQNDVYVLLVKNGKV
EKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSEVKEIGAQ

Specific function: Cell membrane lipoprotein, involved in cell membrane permeability to hydrophobic compounds such as antibiotics, dyes and detergents [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=354, Percent_Identity=31.3559322033898, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1789929, Length=376, Percent_Identity=31.3829787234043, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786668, Length=364, Percent_Identity=30.7692307692308, Blast_Score=151, Evalue=7e-38,
Organism=Escherichia coli, GI87082036, Length=345, Percent_Identity=28.4057971014493, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87081951, Length=132, Percent_Identity=34.8484848484849, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789637, Length=179, Percent_Identity=30.7262569832402, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40178; Mature: 40178

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDY
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCHHHHCCC
DVIIKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASK
EEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEHHHHHCCCC
DFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTI
CCCHHHHHHHHCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHCEEECCHHEECCCCCCCH
GDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLN
HHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCEEHEEEEEEEE
LNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQ
ECCCEEEEEEEEEEEEEECCCCEEEEEEEEECCCCEECCCCCEEECCCCEEECCCCCCCE
IAIKQDQNDVYVLLVKNGKVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSE
EEEEECCCCEEEEEECCCCEEEEEEEEEEECCEEEEEECCCCCCCEEEECCCEEEECCCH
VKEIGAQ
HHHHCCC
>Mature Secondary Structure
MKLFQKNTILVLGVVFLLTACSKEEAPKIQMPPQPVTTMSAKSEDLPLNFTYPAKLVSDY
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEECCHHHHCCC
DVIIKPQVSGVIVNKLFKAGDKVKRGQTLFIIEQAKFKASVDSAYGQALMAKATFENASK
EEEEECCCCHHHHHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHEEEHHHHHCCCC
DFNRSEALFSKNAISQKEYDSSLATFNNAKASLASARAQLANARIDLDHTEIKAPFDGTI
CCCHHHHHHHHCCCCHHHHCCHHHHCCCCHHHHHHHHHHHHHCEEECCHHEECCCCCCCH
GDALVNIGDYVSTSTTELVRVTNLNPIYADFFISDTDKLNLVRNTQSGKWDLDSIHANLN
HHHHHHCCCCCCCCCEEEEEEECCCCEEEEEEECCCCCEEEEECCCCCCEEHEEEEEEEE
LNGETVQGKLYFIDSVIDANSGTVKAKAVFDNNNSTLLPGAFATITSEGFIQKNGFKVPQ
ECCCEEEEEEEEEEEEEECCCCEEEEEEEEECCCCEECCCCCEEECCCCEEECCCCCCCE
IAIKQDQNDVYVLLVKNGKVEKSSVHISYQNNEYAIIDKGLQNGDKIILDNFKKIQVGSE
EEEEECCCCEEEEEECCCCEEEEEEEEEEECCEEEEEECCCCCCCEEEECCCEEEECCCH
VKEIGAQ
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8196548 [H]