Click here to switch to the map view.

The map label for this gene is tkt [H]

Identifier: 153951644

GI number: 153951644

Start: 1767097

End: 1768995

Strand: Direct

Name: tkt [H]

Synonym: JJD26997_2005

Alternate gene names: 153951644

Gene position: 1767097-1768995 (Clockwise)

Preceding gene: 153952306

Following gene: 153951693

Centisome position: 95.77

GC content: 36.12

Gene sequence:

>1899_bases
ATGAACATTCAAATTTTACAAGAACAGGCAAATACTCTAAGATTTTTAAGTGCTGATATGGTACAAAAAGCAAACTCAGG
ACACCCAGGTGCACCTTTGGGCTTAGCAGATATTTTAAGTGTTTTAAGTTATCATTTAAAACACAATCCCAAAAATCCAA
CTTGGCTAAACCGAGATAGACTTGTATTTTCAGGCGGACATGCAAGTGCTTTGCTTTATAGTTTTTTACATTTAAGTGGT
TATGATTTAAGCTTAGAAGATCTTAAAAATTTCCGCCAACTTCATTCTAAAACCCCTGGACACCCTGAAATTTCAACTCT
TGGAGTAGAAATCGCTACAGGTCCTTTAGGACAAGGCGTTGCCAACGCTGTAGGCTTTGCTATGGCAGCAAAAAAAGCGC
AAAATTTACTAGGTGGTGATTTAATCGATCATAAAATTTATTGTCTTTGTGGAGATGGGGATTTACAAGAAGGCATTTCT
TATGAAGCTTGTTCTTTAGCAGGACTTCACAAACTTGATAATTTCATACTCGTTTATGATAGCAACAATATCTCCATAGA
AGGCGATGTAGGTTTAGCCTTTAACGAAAATATAAAAATGCGTTTTGAAGCACAAGGATTTGAAGTTTTAAGTATAAATG
GACACGATTATGAAGAAATCAATAAAGCCTTAGAACAAGCTAAAAAAACTACAAAACCTTGTCTTATCATCGCAAAAACA
ACTATAGCAAAGGGTGCAGGAGAGCTTGAAGGCAGCCATAAAAGCCATGGCGCACCTTTGGGTGAAGAAGTGATTAAAAA
AGCCAAAGAACAAGCAGGTTTTGATCCAAATATCAGTTTTCACATCCCACAAGCAAGTAAAATCCGCTTTGAAAGTGCTG
TAGAACTTGGGGATTTAGAAGAAGCAAAATGGAAAGATAAGCTTGAAAAAAGTGGTAAAAAAGAACTTTTAGAAAGACTA
TTAAATCCTGCTTTTAGCAAGATAGCTTATCCTGATTTTAAAGGAAAAGATCTTGCTACAAGAGATAGCAATGGTGAAAT
TTTAAATGTTTTAGCTAAAAATTTAGAAGGATTTTTAGGTGGAAGTGCGGATTTAGGCCCTTCAAATAAAACAGAACTTC
ACGGCATGGGGGACTTTGTAGAAGGTAAAAATATCCATTTTGGTATCAGAGAACACGCTATGGCAGCGATTAACAATGCT
TTTGCAAGATATGGAATTTTCTTACCATTTTCGGCAACTTTTTTCATCTTTAGCGAGTACTTAAAACCTGCCGCAAGAAT
AGCAGCCCTAATGAAAATCAAACATTTTTTTATTTTCACGCACGATAGCATAGGCGTGGGTGAAGATGGGCCAACACACC
AGCCTATAGAACAACTTAGCACCTTTAGGGCTATGCCAAATTTTTTAACCTTTAGACCTGCTGATGGGGTAGAAAATGTC
AAAGCTTGGCAAATAGCCCTAAATGCTGATATTCCGAGTGCTTTTGTACTTTCACGCCAAAAACTCAAAGCCCTAAACGA
ACCTGTTTTTGGAGATGTAAAAAACGGAGCGTATTTGCTTAAAGAAAGCAAAGATGCTAAATTTACACTTCTAGCAAGTG
GAAGTGAAGTTTGGCTTTGCCTAGAAAGTGCAAACGAACTTGAAAAACAAGGTTTTGCTTGTAATGTTGTTTCCATGCCT
TGTTTTGAACTTTTTGAAAAACAAGATAAAGCTTATCAAGAAAGATTGTTAAAAGGTGAAGTTATAGGCGTTGAAGCAGC
ACATTCTAATGAACTTTATAAATTTTGCCACAAAGTGTATGGTATAAAAAGTTTTGGAGAAAGCGGCAAAGACAAAGATG
TGTTTGAACACTTTGACTTTAGCGTTTCAAAGCTGATGAATTTCATCCTTAGCAAATAA

Upstream 100 bases:

>100_bases
AATCTTCTTAGTGAATGCGAACAAGACTTAGAAAAACTTAATGAAAAACTCGCACAAATGATACAAAATTTAATAATTCA
ATACTTATAAAGGCAAAATA

Downstream 100 bases:

>100_bases
AATGAATACAAATTTCAAATTTCAAAATAACACTCTTTTCATCTTTGGAATTTGGGATAAAACAAGCATTTATAAGTTAA
AAATAAAAGATTTTTTAGCT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 632; Mature: 632

Protein sequence:

>632_residues
MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGGDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILVYDSNNISIEGDVGLAFNENIKMRFEAQGFEVLSINGHDYEEINKALEQAKKTTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSGKKELLERL
LNPAFSKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKDAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIKSFGESGKDKDVFEHFDFSVSKLMNFILSK

Sequences:

>Translated_632_residues
MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGGDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILVYDSNNISIEGDVGLAFNENIKMRFEAQGFEVLSINGHDYEEINKALEQAKKTTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSGKKELLERL
LNPAFSKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKDAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIKSFGESGKDKDVFEHFDFSVSKLMNFILSK
>Mature_632_residues
MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDRLVFSGGHASALLYSFLHLSG
YDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGVANAVGFAMAAKKAQNLLGGDLIDHKIYCLCGDGDLQEGIS
YEACSLAGLHKLDNFILVYDSNNISIEGDVGLAFNENIKMRFEAQGFEVLSINGHDYEEINKALEQAKKTTKPCLIIAKT
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLEEAKWKDKLEKSGKKELLERL
LNPAFSKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLGGSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNA
FARYGIFLPFSATFFIFSEYLKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKDAKFTLLASGSEVWLCLESANELEKQGFACNVVSMP
CFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVYGIKSFGESGKDKDVFEHFDFSVSKLMNFILSK

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=591, Percent_Identity=28.595600676819, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI4507521, Length=591, Percent_Identity=28.595600676819, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI133778974, Length=645, Percent_Identity=25.8914728682171, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI225637459, Length=597, Percent_Identity=24.9581239530988, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI225637463, Length=486, Percent_Identity=25.7201646090535, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI225637461, Length=486, Percent_Identity=25.7201646090535, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=44.2922374429224, Blast_Score=516, Evalue=1e-147,
Organism=Escherichia coli, GI1788808, Length=663, Percent_Identity=42.684766214178, Blast_Score=485, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17539652, Length=591, Percent_Identity=29.6108291032149, Blast_Score=209, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6325331, Length=642, Percent_Identity=44.392523364486, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6319593, Length=644, Percent_Identity=40.9937888198758, Blast_Score=458, Evalue=1e-129,
Organism=Drosophila melanogaster, GI45551847, Length=563, Percent_Identity=27.708703374778, Blast_Score=195, Evalue=1e-49,
Organism=Drosophila melanogaster, GI45550715, Length=563, Percent_Identity=27.708703374778, Blast_Score=195, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24666278, Length=598, Percent_Identity=27.4247491638796, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24645119, Length=526, Percent_Identity=27.1863117870722, Blast_Score=171, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 69562; Mature: 69562

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDR
CCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCC
LVFSGGHASALLYSFLHLSGYDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGV
EEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHH
ANAVGFAMAAKKAQNLLGGDLIDHKIYCLCGDGDLQEGISYEACSLAGLHKLDNFILVYD
HHHHHHHHHHHHHHHHHCCCEECCEEEEEECCCCHHHCCCCCHHHHHHHHHCCCEEEEEE
SNNISIEGDVGLAFNENIKMRFEAQGFEVLSINGHDYEEINKALEQAKKTTKPCLIIAKT
CCCEEEECCEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEH
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHCCHHHHCCCCCCH
EAKWKDKLEKSGKKELLERLLNPAFSKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNAFARYGIFLPFSATFFIFSEY
CCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCEEECHHHHHHHHHHH
LKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
HHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKDAKFTLLASGSEVWLC
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEEEE
LESANELEKQGFACNVVSMPCFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVY
ECCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
GIKSFGESGKDKDVFEHFDFSVSKLMNFILSK
CHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCC
>Mature Secondary Structure
MNIQILQEQANTLRFLSADMVQKANSGHPGAPLGLADILSVLSYHLKHNPKNPTWLNRDR
CCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEECCCC
LVFSGGHASALLYSFLHLSGYDLSLEDLKNFRQLHSKTPGHPEISTLGVEIATGPLGQGV
EEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHH
ANAVGFAMAAKKAQNLLGGDLIDHKIYCLCGDGDLQEGISYEACSLAGLHKLDNFILVYD
HHHHHHHHHHHHHHHHHCCCEECCEEEEEECCCCHHHCCCCCHHHHHHHHHCCCEEEEEE
SNNISIEGDVGLAFNENIKMRFEAQGFEVLSINGHDYEEINKALEQAKKTTKPCLIIAKT
CCCEEEECCEEEEECCCEEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEH
TIAKGAGELEGSHKSHGAPLGEEVIKKAKEQAGFDPNISFHIPQASKIRFESAVELGDLE
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHCCHHHHCCCCCCH
EAKWKDKLEKSGKKELLERLLNPAFSKIAYPDFKGKDLATRDSNGEILNVLAKNLEGFLG
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GSADLGPSNKTELHGMGDFVEGKNIHFGIREHAMAAINNAFARYGIFLPFSATFFIFSEY
CCCCCCCCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCEEECHHHHHHHHHHH
LKPAARIAALMKIKHFFIFTHDSIGVGEDGPTHQPIEQLSTFRAMPNFLTFRPADGVENV
HHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCCCC
KAWQIALNADIPSAFVLSRQKLKALNEPVFGDVKNGAYLLKESKDAKFTLLASGSEVWLC
EEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCEEEEE
LESANELEKQGFACNVVSMPCFELFEKQDKAYQERLLKGEVIGVEAAHSNELYKFCHKVY
ECCHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHH
GIKSFGESGKDKDVFEHFDFSVSKLMNFILSK
CHHHHCCCCCCCHHHHHHCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]