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The map label for this gene is yrkA [H]

Identifier: 153951504

GI number: 153951504

Start: 179866

End: 181152

Strand: Direct

Name: yrkA [H]

Synonym: JJD26997_0191

Alternate gene names: 153951504

Gene position: 179866-181152 (Clockwise)

Preceding gene: 153951263

Following gene: 153951136

Centisome position: 9.75

GC content: 31.78

Gene sequence:

>1287_bases
ATGGTTGTTGTTGCACTTGCTCTAGTGTTTTTAAATAGTTTTTTTGTTTTGTCTGAATTTAGTATTGTTAAAGTACGTCG
TTCCAAGCTTGAAGAGATGGTAAAAGAAAAAAAAGCCAGTGCTAAGAAAGCTTTGGAGGTTACTTCAAGACTCGATACTT
ATCTTAGTGCTTGTCAATTAGGAATTACTTTAAGTTCTCTAGCTCTTGGTTGGATAGGTGAGCCCGCTATTGCAAAAATG
CTAGAAATTCCGCTTATTAATCTTGGTTTTAGCACTGTTATTATCCATACTATAGCTTTTATTATTGCTTTTAGCATTAT
TACTCTTTTACATGTGGTTTTAGGAGAACTTGTGCCAAAAAGTATAGCTATTGCAGTTGCAGATAAAGCAGTTTTATTTA
TAGCTAGACCGCTTCATTGGTTTTGGATACTCTTTTTGCCTTGTATTAAAATTTTCGATTTTTTAGCAGGTATAAGTTTG
AAACTTTTTGGAATAAAACCTGCTAAAGAAAGCGAGCTAACTCATAGCGAAGAAGAAATTAAAATCATAGCAAGTGAGAG
TCAAAAAGGTGGAGTTTTAGATGAATTTGAAACAGAGATCATACGCAATGCTGTTGATTTTTCAGATACTGTTGCTAAAG
AGATTATGACTCCTAGAAAAGATATGATTTGTCTAAATAAACAAAAAAATTACGAAGAAAATATGCAAATCATTTGTGAA
CATAAACATACTCGCTTTCCTTATATTGATGGTTCTAAAGATACTATTTTAGGGATGATACACATACGAGATATAATACA
AAATGAATTAAGCCATAAAAGTCAAAATTTAGATACTTTTGTTAAACCTTTGATTTTGGTTCCTGAAAATATCAGTATTT
CAAAAGTACTTGTAATGATGAATAAAGAACGCTCTCATACTGCATTAGTAGTTGATGAGTATGGTGGAACTGCTGGAATT
TTAACCATGGAAGATATCATGGAAGAAATTATTGGCGAAATTAAAAGCGAGCATGAAGAAGACAGCTATAAAAAACTTGC
TGAAAATATCTATGAATTTCAAGGACGATGCGATATAGAAACTGTTGAAGAAATGCTTGTAATAAACTATGATGAGGATT
TAGAACAAGTTACCATAGGTGGATATGTATTTAATCTTTTAGGACGCTTGCCTATGGTAGGAGATCGCATTGAAGATGAA
CTTTGTTACTATGAAGTTAAAAAAATGGATGGGAATTCTATAGAGCGTGTTAAGGTGGTTAAAAAAACAAATAAAGATGA
AGAATAA

Upstream 100 bases:

>100_bases
AATAATATTTTATTTTTAAGGAGCTTCATTGGACCCCAGTCAGGTTTTGGATTTAAACCAAACTTCTACAGCATCTTTTG
ATGCAGGATATTCTATACTT

Downstream 100 bases:

>100_bases
GCCTCTTTAGGCTTATTTCTTTTTGTAAATTTGGTTTTTAATTTCTATACACTCAAAACCTTTTTTATCTAGTGTAACTA
CGCGTAAATATCCACCATCA

Product: putative transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MVVVALALVFLNSFFVLSEFSIVKVRRSKLEEMVKEKKASAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWILFLPCIKIFDFLAGISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKNYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELSHKSQNLDTFVKPLILVPENISISKVLVMMNKERSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE

Sequences:

>Translated_428_residues
MVVVALALVFLNSFFVLSEFSIVKVRRSKLEEMVKEKKASAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWILFLPCIKIFDFLAGISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKNYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELSHKSQNLDTFVKPLILVPENISISKVLVMMNKERSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE
>Mature_428_residues
MVVVALALVFLNSFFVLSEFSIVKVRRSKLEEMVKEKKASAKKALEVTSRLDTYLSACQLGITLSSLALGWIGEPAIAKM
LEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPKSIAIAVADKAVLFIARPLHWFWILFLPCIKIFDFLAGISL
KLFGIKPAKESELTHSEEEIKIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKNYEENMQIICE
HKHTRFPYIDGSKDTILGMIHIRDIIQNELSHKSQNLDTFVKPLILVPENISISKVLVMMNKERSHTALVVDEYGGTAGI
LTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDE
LCYYEVKKMDGNSIERVKVVKKTNKDEE

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=386, Percent_Identity=40.9326424870466, Blast_Score=295, Evalue=7e-80,
Organism=Escherichia coli, GI1790664, Length=427, Percent_Identity=23.1850117096019, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1786879, Length=257, Percent_Identity=28.7937743190661, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI145693175, Length=431, Percent_Identity=22.969837587007, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87082033, Length=237, Percent_Identity=26.1603375527426, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1788119, Length=239, Percent_Identity=21.7573221757322, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48465; Mature: 48465

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVVALALVFLNSFFVLSEFSIVKVRRSKLEEMVKEKKASAKKALEVTSRLDTYLSACQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITLSSLALGWIGEPAIAKMLEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPK
HHHHHHHHHHCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SIAIAVADKAVLFIARPLHWFWILFLPCIKIFDFLAGISLKLFGIKPAKESELTHSEEEI
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCE
KIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKNYEENMQIICE
EEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHEEEECCCCCCHHHHHEEEC
HKHTRFPYIDGSKDTILGMIHIRDIIQNELSHKSQNLDTFVKPLILVPENISISKVLVMM
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHEEE
NKERSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIE
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMDGNSIERVKVV
HHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KKTNKDEE
HHCCCCCC
>Mature Secondary Structure
MVVVALALVFLNSFFVLSEFSIVKVRRSKLEEMVKEKKASAKKALEVTSRLDTYLSACQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GITLSSLALGWIGEPAIAKMLEIPLINLGFSTVIIHTIAFIIAFSIITLLHVVLGELVPK
HHHHHHHHHHCCCCHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SIAIAVADKAVLFIARPLHWFWILFLPCIKIFDFLAGISLKLFGIKPAKESELTHSEEEI
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCE
KIIASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKNYEENMQIICE
EEEECCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHEEEECCCCCCHHHHHEEEC
HKHTRFPYIDGSKDTILGMIHIRDIIQNELSHKSQNLDTFVKPLILVPENISISKVLVMM
CCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHEECCCCCCHHHHHEEE
NKERSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSEHEEDSYKKLAENIYEFQGRCDIE
CCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHH
TVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMDGNSIERVKVV
HHHHHHEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
KKTNKDEE
HHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 8969508; 7608059 [H]