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The map label for this gene is folE [H]

Identifier: 153951136

GI number: 153951136

Start: 190082

End: 190654

Strand: Direct

Name: folE [H]

Synonym: JJD26997_0204

Alternate gene names: 153951136

Gene position: 190082-190654 (Clockwise)

Preceding gene: 153951504

Following gene: 153951633

Centisome position: 10.3

GC content: 32.11

Gene sequence:

>573_bases
TTGCAAAAAAAATTTGAAGATTGTGTTAAAACCATGCTTGAAATTATAGGAGAAAATCCAAATCGTGAAGGACTTATTAA
AACACCAAATCGTGTTTTTAAAGCTTATGAATTTCTTACTAGTGGTTATACACAAAATGTCAAAGAAATTTTAAATGATG
CTTTATTTGAAAGCTCTAATAATGAAATGGTTTTGGTGCGTGATATAGAATTTTATAGTCTTTGTGAACATCATCTTTTA
CCTTTTTTTGGGCGTGCTCATGTAGCCTATATCCCTAATAAAAAAGTAGTAGGTTTAAGCAAAATTCCACGCCTTGTAGA
GGTGTTTGCAAGAAGACTTCAAATCCAAGAACAACTTACCGAACAAATCGCGCAAGCTTTAATGGAAAATGCCGATGCAA
AAGGTGTTGGCGTAATTATAGAAGCAAGACATATGTGTGTTGAAATGCGTGGAGTACAAAAAGCTAATTCTACCACTACA
ACTTCAGCTTTGCGTGGAATTTTCTTAAAAAATGAAAAAATTAGAGAAGAATTTTTTTCTCTCATAAACTCTGCTAAACA
GGTAAGATTTTAA

Upstream 100 bases:

>100_bases
AAATTTTTCCTTATTACTTGCATAAAATTTTAAAGTAATTTATGATAAAATTACAATGTTACATTATTATTAAAATATAA
AAATATTTTTGGAGAAAAAT

Downstream 100 bases:

>100_bases
TGAATCTTGAAAAACTGCGCTCCAAACTTGGCAAAGAAAATTTAAGTGCTATTTTTGGAGAGATTACAAAAATTTCTGCT
ACAAGTATAGAAATTCGTGG

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 190; Mature: 190

Protein sequence:

>190_residues
MQKKFEDCVKTMLEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENADAKGVGVIIEARHMCVEMRGVQKANSTTT
TSALRGIFLKNEKIREEFFSLINSAKQVRF

Sequences:

>Translated_190_residues
MQKKFEDCVKTMLEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENADAKGVGVIIEARHMCVEMRGVQKANSTTT
TSALRGIFLKNEKIREEFFSLINSAKQVRF
>Mature_190_residues
MQKKFEDCVKTMLEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSNNEMVLVRDIEFYSLCEHHLL
PFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLTEQIAQALMENADAKGVGVIIEARHMCVEMRGVQKANSTTT
TSALRGIFLKNEKIREEFFSLINSAKQVRF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=174, Percent_Identity=53.448275862069, Blast_Score=220, Evalue=6e-58,
Organism=Homo sapiens, GI4503949, Length=174, Percent_Identity=53.448275862069, Blast_Score=220, Evalue=6e-58,
Organism=Homo sapiens, GI66932972, Length=132, Percent_Identity=52.2727272727273, Blast_Score=169, Evalue=1e-42,
Organism=Homo sapiens, GI66932970, Length=132, Percent_Identity=52.2727272727273, Blast_Score=169, Evalue=1e-42,
Organism=Escherichia coli, GI1788476, Length=161, Percent_Identity=43.4782608695652, Blast_Score=112, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=174, Percent_Identity=54.5977011494253, Blast_Score=218, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=52.1978021978022, Blast_Score=204, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24656782, Length=175, Percent_Identity=51.4285714285714, Blast_Score=197, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24656791, Length=175, Percent_Identity=51.4285714285714, Blast_Score=197, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24656796, Length=175, Percent_Identity=51.4285714285714, Blast_Score=197, Evalue=5e-51,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21799; Mature: 21799

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKFEDCVKTMLEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSN
CCCHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
NEMVLVRDIEFYSLCEHHLLPFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLT
CCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EQIAQALMENADAKGVGVIIEARHMCVEMRGVQKANSTTTTSALRGIFLKNEKIREEFFS
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LINSAKQVRF
HHHHHHHCCC
>Mature Secondary Structure
MQKKFEDCVKTMLEIIGENPNREGLIKTPNRVFKAYEFLTSGYTQNVKEILNDALFESSN
CCCHHHHHHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
NEMVLVRDIEFYSLCEHHLLPFFGRAHVAYIPNKKVVGLSKIPRLVEVFARRLQIQEQLT
CCEEEEECCHHHHHHHHHHHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHH
EQIAQALMENADAKGVGVIIEARHMCVEMRGVQKANSTTTTSALRGIFLKNEKIREEFFS
HHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHH
LINSAKQVRF
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA