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The map label for this gene is accC-2 [H]

Identifier: 153951320

GI number: 153951320

Start: 380637

End: 381968

Strand: Direct

Name: accC-2 [H]

Synonym: JJD26997_0432

Alternate gene names: 153951320

Gene position: 380637-381968 (Clockwise)

Preceding gene: 153952169

Following gene: 153951105

Centisome position: 20.63

GC content: 34.91

Gene sequence:

>1332_bases
ATGGAAATTAAAAGCATTTTAATTGCTAATCGTGGAGAAATAGCACTACGTGCTTTAAGAACGATTAAAGAAATGGGTAA
AAAAGCCATTTGTGTATATTCTGAAGCAGATAAAGATGCTTTATATTTAAAATACGCTGATGCAAGCATTTGTATAGGCA
AAGCAAGAAGTTCTGAAAGTTATTTAAATATCCCAGCTATTATTACAGCGGCTGAAATTGCTGAAGCAGATGCGATTTTT
CCAGGATATGGATTTTTAAGCGAAAATCAAAATTTTGTTGAAATTTGCGCTAAACATAACATCAAATTTATAGGTCCTTC
TGTGGAAGCTATGAATTTAATGAGTGATAAATCAAAAGCCAAACAAGTAATGCAAAGAGCAGGTGTACCTGTGATCCCAG
GAAGTGATGGAGCTTTAGCAGGAGCTGAAGCAGCTAAAAAACTTGCTAAAGAAATAGGTTATCCTGTGATTTTAAAAGCA
GCTGCAGGTGGTGGTGGTCGTGGTATGCGTGTAGTTGAAAATGAAAAAGATCTTGAAAAAGCGTATTGGTCAGCTGAAAG
TGAGGCCATGACAGCATTTGGTGATGGAACTATGTATATGGAAAAATATATACAAAATCCACGCCATATAGAAGTTCAGG
TTATAGGAGATAGTTTTGGTAATGTGATTCATGTGGGAGAAAGAGATTGTTCTATGCAAAGACGCCATCAAAAACTTATA
GAAGAATCCCCTGCAATTTTGCTTGATGAAAAAACACGTACTAGACTTCATGAAACTGCTATTAAGGCAGCTAAAGCTAT
AGGTTATGAAGGTGCGGGGACTTTTGAGTTTTTAGTAGATAAAAATTTAGACTTTTATTTTATAGAAATGAATACGCGTT
TGCAAGTTGAACACTGTGTAAGTGAAATGGTAAGTGGGATTGATATCATAGAACAAATGATTAAAGTAGCAGAAGGTTAT
GCTTTGCCAGCTCAAGAAAGTATTAAATTAAATGGGCATTCTATAGAATGTAGAATCACAGCTGAAGATTCTAAAACCTT
CTTGCCAAGTCCAGGTAAGATTACTAAATACATTCCACCCGCAGGACGCAATGTCAGAATGGAAAGTCATTGTTATCAAG
ACTATAGCGTGCCACCTTATTATGATTCTATGATAGGTAAGCTTGTAGTTTGGGCAGAAGATCGCAATAAAGCCATTGCA
AAAATGAAAGTAGCTTTAGATGAGTTACTTATAAGTGGGATAAAAACAACCAAAGATTTTCATCTTTCTATGATGGAAAA
TCCTGATTTTATCAATAATAACTACGATACAAATTATCTTGCAAGACATTAA

Upstream 100 bases:

>100_bases
ATTGAAGCGGAATTTGATTGTAGGATCGCTGAAATTTTAGTTGCTGATGGTCAGCCTGTAGAATTTGGAATGCCTTTATT
TGCGGTGGAGAAATTATAAA

Downstream 100 bases:

>100_bases
AATTTCCCTATTAAAGGGAAATTAATTGTAATTTTTATCTTAAATATTCTATATTGATTTTAGAGCGGAGTTTATCAAAA
TAATCTTGTATGAAATTTTG

Product: biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARSSESYLNIPAIITAAEIAEADAIF
PGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDKSKAKQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKA
AAGGGGRGMRVVENEKDLEKAYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQKLI
EESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVEHCVSEMVSGIDIIEQMIKVAEGY
ALPAQESIKLNGHSIECRITAEDSKTFLPSPGKITKYIPPAGRNVRMESHCYQDYSVPPYYDSMIGKLVVWAEDRNKAIA
KMKVALDELLISGIKTTKDFHLSMMENPDFINNNYDTNYLARH

Sequences:

>Translated_443_residues
MEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARSSESYLNIPAIITAAEIAEADAIF
PGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDKSKAKQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKA
AAGGGGRGMRVVENEKDLEKAYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQKLI
EESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVEHCVSEMVSGIDIIEQMIKVAEGY
ALPAQESIKLNGHSIECRITAEDSKTFLPSPGKITKYIPPAGRNVRMESHCYQDYSVPPYYDSMIGKLVVWAEDRNKAIA
KMKVALDELLISGIKTTKDFHLSMMENPDFINNNYDTNYLARH
>Mature_443_residues
MEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARSSESYLNIPAIITAAEIAEADAIF
PGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDKSKAKQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKA
AAGGGGRGMRVVENEKDLEKAYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQKLI
EESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVEHCVSEMVSGIDIIEQMIKVAEGY
ALPAQESIKLNGHSIECRITAEDSKTFLPSPGKITKYIPPAGRNVRMESHCYQDYSVPPYYDSMIGKLVVWAEDRNKAIA
KMKVALDELLISGIKTTKDFHLSMMENPDFINNNYDTNYLARH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=45.945945945946, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=44.5454545454545, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=44.5454545454545, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=44.5454545454545, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=43.5955056179775, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=43.5955056179775, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=43.5955056179775, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=30.511811023622, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=30.511811023622, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=30.511811023622, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=30.511811023622, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=30.511811023622, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI134142062, Length=511, Percent_Identity=30.1369863013699, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI18105007, Length=236, Percent_Identity=25.4237288135593, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789654, Length=442, Percent_Identity=53.393665158371, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1786216, Length=237, Percent_Identity=22.3628691983122, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=444, Percent_Identity=46.3963963963964, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17567343, Length=439, Percent_Identity=44.4191343963554, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=42.5389755011136, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=29.5275590551181, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=29.5275590551181, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI133931226, Length=489, Percent_Identity=29.6523517382413, Blast_Score=211, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI193204318, Length=272, Percent_Identity=23.1617647058824, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.9864559819413, Blast_Score=356, Evalue=5e-99,
Organism=Saccharomyces cerevisiae, GI6319695, Length=448, Percent_Identity=42.4107142857143, Blast_Score=332, Evalue=5e-92,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=42.6339285714286, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6323863, Length=456, Percent_Identity=33.3333333333333, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6324343, Length=514, Percent_Identity=31.1284046692607, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322569, Length=272, Percent_Identity=22.4264705882353, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24651757, Length=443, Percent_Identity=44.2437923250564, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=45.3125, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=45.3125, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651759, Length=405, Percent_Identity=44.1975308641975, Blast_Score=351, Evalue=6e-97,
Organism=Drosophila melanogaster, GI161076407, Length=501, Percent_Identity=30.1397205588822, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24586460, Length=501, Percent_Identity=30.1397205588822, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI161076409, Length=501, Percent_Identity=30.1397205588822, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24586458, Length=501, Percent_Identity=30.1397205588822, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI45555749, Length=285, Percent_Identity=22.4561403508772, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642586, Length=285, Percent_Identity=22.4561403508772, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49132; Mature: 49132

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARSSES
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCC
YLNIPAIITAAEIAEADAIFPGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDKSKA
EECCCHHEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
KQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKAAAGGGGRGMRVVENEKDLEK
HHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHH
AYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQKLI
HHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVEHCV
HCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCEEHHHHH
SEMVSGIDIIEQMIKVAEGYALPAQESIKLNGHSIECRITAEDSKTFLPSPGKITKYIPP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEECCCCEECCCCCCEEEECCC
AGRNVRMESHCYQDYSVPPYYDSMIGKLVVWAEDRNKAIAKMKVALDELLISGIKTTKDF
CCCCEEEHHHCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
HLSMMENPDFINNNYDTNYLARH
EEEEECCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MEIKSILIANRGEIALRALRTIKEMGKKAICVYSEADKDALYLKYADASICIGKARSSES
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCEEEEECCCCCCC
YLNIPAIITAAEIAEADAIFPGYGFLSENQNFVEICAKHNIKFIGPSVEAMNLMSDKSKA
EECCCHHEEHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCHHHHHHHHHHHHH
KQVMQRAGVPVIPGSDGALAGAEAAKKLAKEIGYPVILKAAAGGGGRGMRVVENEKDLEK
HHHHHHCCCCEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCHHHHHH
AYWSAESEAMTAFGDGTMYMEKYIQNPRHIEVQVIGDSFGNVIHVGERDCSMQRRHQKLI
HHHCCCCCEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCHHHHHHHHHHH
EESPAILLDEKTRTRLHETAIKAAKAIGYEGAGTFEFLVDKNLDFYFIEMNTRLQVEHCV
HCCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCEEHHHHH
SEMVSGIDIIEQMIKVAEGYALPAQESIKLNGHSIECRITAEDSKTFLPSPGKITKYIPP
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEEEEEEECCCCEECCCCCCEEEECCC
AGRNVRMESHCYQDYSVPPYYDSMIGKLVVWAEDRNKAIAKMKVALDELLISGIKTTKDF
CCCCEEEHHHCCCCCCCCCHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCE
HLSMMENPDFINNNYDTNYLARH
EEEEECCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]