Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 153951135

GI number: 153951135

Start: 622868

End: 623401

Strand: Direct

Name: cobB [H]

Synonym: JJD26997_0686

Alternate gene names: 153951135

Gene position: 622868-623401 (Clockwise)

Preceding gene: 153952164

Following gene: 153952097

Centisome position: 33.76

GC content: 32.77

Gene sequence:

>534_bases
ATGAAACAAGCGATGTTGTTAAGTGGAGCAGGTTTGTCTGCTCCAAGTGGATTTAAAACTTTTAAAGACAATGATGGACT
TTTGGAAGAATACGATGTAATGGAGGTTTGCTCTGCAACAGGTTTTAGAAAAAATCCTAAAAAAGTGCTTGATTTTTATG
ATACAAGAAGGGCGCAACTTCAAAATGTAAAGCCAAATCATGCTCATGAAAAAATCACAGATAAACAATGCCTAAAATGT
AAAAGCAAGGATTTAAGACATAATATAGTCATGTTTGAAGAGCAAGCTCCTGCTTATGCTACGCTTTATTCTTTGTTAAA
TCAAACTTCGCTTTTTATTAGCATAGGCACAAGTGGGGCGGTTTTGCCTGTAGGGCGTTATGCTTCAATGTGTGAAAAAA
GTATTTTAAATATCTATGAAAAAGATGCGAATTTAGAGTGGTATTTTGATAAAATCTATATAGAAGATATTATAAGCGCT
ATCGATAAAATCGTACTTGATATAGAAAATTTTATGAAAGATGGTAATGTTTGA

Upstream 100 bases:

>100_bases
AATTTATTCCTTTTGATGTATTATATCAAAGTTATTTTTAAAAATAAAACTTAAATTTAAATATTTTTTGTTACTCTTTT
TAAAAAAATAAGGTTTAATA

Downstream 100 bases:

>100_bases
TTCTTTTTTAAGTGGAGTTTTTTTGGGCTTTGGAGTGAGTGTGCCTTTTGGACCTGTAAATATTTTGATTTTAACTTATG
CGTTAAAAGCTTTTAAAAAT

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MKQAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQLQNVKPNHAHEKITDKQCLKC
KSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLEWYFDKIYIEDIISA
IDKIVLDIENFMKDGNV

Sequences:

>Translated_177_residues
MKQAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQLQNVKPNHAHEKITDKQCLKC
KSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLEWYFDKIYIEDIISA
IDKIVLDIENFMKDGNV
>Mature_177_residues
MKQAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQLQNVKPNHAHEKITDKQCLKC
KSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPVGRYASMCEKSILNIYEKDANLEWYFDKIYIEDIISA
IDKIVLDIENFMKDGNV

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Escherichia coli, GI308199517, Length=69, Percent_Identity=46.3768115942029, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 20047; Mature: 20047

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQL
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QNVKPNHAHEKITDKQCLKCKSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCC
VLPVGRYASMCEKSILNIYEKDANLEWYFDKIYIEDIISAIDKIVLDIENFMKDGNV
EEECHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKQAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQL
CCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
QNVKPNHAHEKITDKQCLKCKSKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGA
HCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEECCCCC
VLPVGRYASMCEKSILNIYEKDANLEWYFDKIYIEDIISAIDKIVLDIENFMKDGNV
EEECHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10688204; 7607469 [H]