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The map label for this gene is hisS

Identifier: 153949863

GI number: 153949863

Start: 1398314

End: 1399588

Strand: Direct

Name: hisS

Synonym: YpsIP31758_1187

Alternate gene names: 153949863

Gene position: 1398314-1399588 (Clockwise)

Preceding gene: 153950353

Following gene: 153948923

Centisome position: 29.6

GC content: 50.67

Gene sequence:

>1275_bases
GTGGCAAAGAACATTCAAGCCATCCGTGGTATGAACGATTACCTGCCAGCCGATACGGCAATATGGCAGCGTATCGAAAG
CATCTTGAAGCAAGTGCTAAGCGGTTACGGTTACAGTGAAATCCGTATGCCGATTGTAGAGCAGACCCCGTTATTCAAAC
GCGCTATCGGTGAAGTGACCGATGTGGTTGAAAAAGAGATGTACACCTTTGATGATCGCAATGGCGAAAGTCTGACACTG
CGCCCGGAAGGGACTGCAGGCTGTGTGCGCGCGGGTATTGAACATGGTCTGCTGTACAATCAGGAACAGCGTCTGTGGTA
CATCGGTCCGATGTTCCGCTATGAACGTCCGCAAAAAGGTCGTTATCGTCAGTTCCATCAGTTGGGGGCCGAAGTCTTTG
GTCTGCCAGGGCCAGATATTGATGCCGAGCTGATTTTACTGACAGCCCGCTGGTGGCGTGCATTAGGTATCTTTGAACAT
GTGAAGTTGGAGCTGAACTCTATTGGTTCGTTGGCTGCCCGTGCTGACTATCGAGAAGCGCTGGTGGCGTTCCTGGAGCA
ACATGTTGAGGTATTGGACGAAGATTGTAAGCGCCGTATGTACAGCAATCCGTTGCGGGTGTTAGATTCCAAAAACCCTG
ATGTTCAGCAGTTGCTTGATGATGCGCCAAAACTGTCTGATTATCTGGATGAAGAGTCAAAACAACATTTTGCCGGGTTG
TGTGAACTTTTAGATAAGGCCAGCATCCCATATACCGTTAATGAGCGTTTAGTTCGTGGTTTAGATTATTACAACCGTAC
GGTATTTGAGTGGGTAACGCACAGCCTGGGCGCACAAGGCACAGTCTGTGCGGGTGGGCGTTATGATGGGTTGGTCGAGC
AACTCGGTGGTCGTGCAACACCGGCCGTGGGTTTTGCGATGGGCCTTGAGCGCTTGGTTCTGCTGGTGCAGGCTGTTAAT
GCTGATTTCCAGGTGCCTGCGACAGTTGATGCTTATGTTATCTCCTCCGGTGAGGGGTCGCAAAGTGCTGCGATGCTCCT
TGCTGAGAGCCTACGTGATGCCTTACCAACGCTAAAAATAATGACCAATTACGGTGGCGGTAATGTTAAGAAACAATTTA
CACGCGCTGATAAGTGCGGCGCTCGTGTCGCTTTAATGCTGGGTGAAAGCGAAGTGGCCGCGCAGCAAGTCGTTGTAAAA
GATTTGCGAAATGGTGAACAAGAAACGCTGGCGCAAGCGGATGTTGCTGCGCGTCTGGCTTTGATGTTGGGTTAA

Upstream 100 bases:

>100_bases
ATTGCGCCAATAGAGTTAACGAGCCGTCCCCATTGAATATGCGGGCGGCAAGCCTCTATAATCGGCTTTATTTCTTGCAC
TAAAACTATAGAGAACTGAC

Downstream 100 bases:

>100_bases
GGAGAGAGACACCGTGGAAGTCTATACCACTGAAAATGACCAGGTTGATGCAGTGCGCCGTTTCTTTAGTGAAAATGGTA
AAGCACTGGCCGTGGGTGTG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTL
RPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEH
VKLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGL
CELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVN
ADFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVK
DLRNGEQETLAQADVAARLALMLG

Sequences:

>Translated_424_residues
MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTL
RPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEH
VKLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGL
CELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVN
ADFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVK
DLRNGEQETLAQADVAARLALMLG
>Mature_423_residues
AKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVTDVVEKEMYTFDDRNGESLTLR
PEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKGRYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHV
KLELNSIGSLAARADYREALVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGLC
ELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRATPAVGFAMGLERLVLLVQAVNA
DFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKIMTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVKD
LRNGEQETLAQADVAARLALMLG

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=352, Percent_Identity=26.9886363636364, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788861, Length=424, Percent_Identity=81.8396226415094, Blast_Score=722, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_YERP3 (A7FFZ0)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400168.1
- ProteinModelPortal:   A7FFZ0
- SMR:   A7FFZ0
- STRING:   A7FFZ0
- GeneID:   5385959
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1187
- NMPDR:   fig|349747.3.peg.1358
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   YPSE349747:YPSIP31758_1187-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47196; Mature: 47064

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVT
CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCHHCCCHHHHHHHHHHH
DVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKG
HHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCHHHCCCCCCC
RYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHVKLELNSIGSLAARADYREA
HHHHHHHHHHHHCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
CELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRAT
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCC
PAVGFAMGLERLVLLVQAVNADFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEE
MTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVKDLRNGEQETLAQADVAARLA
EECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LMLG
HHCC
>Mature Secondary Structure 
AKNIQAIRGMNDYLPADTAIWQRIESILKQVLSGYGYSEIRMPIVEQTPLFKRAIGEVT
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEECCHHCCCHHHHHHHHHHH
DVVEKEMYTFDDRNGESLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRYERPQKG
HHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHCCEECCCCCEEEECCHHHCCCCCCC
RYRQFHQLGAEVFGLPGPDIDAELILLTARWWRALGIFEHVKLELNSIGSLAARADYREA
HHHHHHHHHHHHCCCCCCCCCHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAFLEQHVEVLDEDCKRRMYSNPLRVLDSKNPDVQQLLDDAPKLSDYLDEESKQHFAGL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHH
CELLDKASIPYTVNERLVRGLDYYNRTVFEWVTHSLGAQGTVCAGGRYDGLVEQLGGRAT
HHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCC
PAVGFAMGLERLVLLVQAVNADFQVPATVDAYVISSGEGSQSAAMLLAESLRDALPTLKI
CHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEE
MTNYGGGNVKKQFTRADKCGARVALMLGESEVAAQQVVVKDLRNGEQETLAQADVAARLA
EECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LMLG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA