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The map label for this gene is menC

Identifier: 153948854

GI number: 153948854

Start: 1727516

End: 1728487

Strand: Direct

Name: menC

Synonym: YpsIP31758_1485

Alternate gene names: 153948854

Gene position: 1727516-1728487 (Clockwise)

Preceding gene: 153947086

Following gene: 153948224

Centisome position: 36.57

GC content: 57.2

Gene sequence:

>972_bases
ATGCGCACGGCTACCCTTTACCGCTACAGTGTACCGATGGAAGCGGGGGTGATACTGCGCCATCAGCGGCTGAAAAGTCG
CGATGGGTTGCTGGTCAAATTACAGCAAGGTGAATTGAGCGGCTGGGGCGAAATTGCCCCGTTACCGGAATTCAGTCAAG
AAACACTGGATCAAGCCCAAGTGGCGGCAGAGTGTTGGCTGCAACACTGGGTCAGTGGTGTCGAATCGGATGACAGCGTG
TTGCCCTCCGTGGCTTTTGGTCTCAGTTGTGCGCAGGCCGAACTCAACCAAACCTTACCGCTGTCAGCGGATTATCGCAA
AGCGCCACTGTGTACCGGCGATCCTGATGAGCTGTTTGCGGTACTCCAGGCATTGCCGGGTGAGAAGGTTGCCAAGGTGA
AGGTCGGGCTGTATGAAGCGGTGCGTGATGGCATGATCGTTAATGTTCTGTTGGAAGCCCTGCCTGATCTGACACTGCGG
CTGGACGCCAATCGCAGTTGGAGCCGAGCGAAGGCCGATGGGTTCGCGAAGTATGTCAATCCGGCGCTGCGTTCGCGTAT
TGCCTTTCTGGAGGAACCGTGCAAAACCCGCGCTGAATCCCGTGAGTTTGCTCAAGATACCGGTATTGCTATTGCCTGGG
ATGAAAGTGTGCGTGAGGCGGATTTTCAGGTTGAAGCCGAGCCGGGAGTGGCGGCAATTGTGATCAAACCAACGCTGGTG
GGCAGTCTTTCTCGCTGTCAGCAACTGGTGCAACAAGCGCATCAGGCCGGTTTGGTTGCGGTTATTAGCTCCAGTATTGA
ATCCAGTCTGGGTCTGACGCAATTGGCCCGTTTGGCCGCTTGGTTGACCCCCGCCACGGTTCCGGGGTTGGATACGCTGG
ACCTGATGCAGGCGCAAGTCGTGCGGCCGTGGCCAGACAGCCCGTTGCCGCTAATCACGACCGAGCAGTTGGGCGTGGTA
TGGCATCGTTAG

Upstream 100 bases:

>100_bases
CCACCATGCTGTTCTATATGACCGATGAAGGGCAGGAGGGGCGTAACGCATTCAATGAAAAACGCCAGCCGGACTTCAGC
AAATTCAAGCGTAATCCGTA

Downstream 100 bases:

>100_bases
GCCATCCGCCTTGGGAGCATTGGCCTTGGCAGTATTGGGCCAATCTGCGGCCTCAAGCGCTCGCTATACGTTCTGGGGGG
CAACGGATCAGTTGGCAACA

Product: O-succinylbenzoate synthase

Products: NA

Alternate protein names: OSB synthase; OSBS; 4-(2'-carboxyphenyl)-4-oxybutyric acid synthase; o-succinylbenzoic acid synthase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSV
LPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLR
LDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLV
GSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVV
WHR

Sequences:

>Translated_323_residues
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSV
LPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLR
LDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLV
GSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVV
WHR
>Mature_323_residues
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQVAAECWLQHWVSGVESDDSV
LPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFAVLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLR
LDANRSWSRAKADGFAKYVNPALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLV
GSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQVVRPWPDSPLPLITTEQLGVV
WHR

Specific function: Converts SHCHC to OSB

COG id: COG1441

COG function: function code H; O-succinylbenzoate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1788596, Length=317, Percent_Identity=66.2460567823344, Blast_Score=424, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENC_YERP3 (A7FGT5)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001400463.1
- ProteinModelPortal:   A7FGT5
- SMR:   A7FGT5
- STRING:   A7FGT5
- GeneID:   5388010
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_1485
- NMPDR:   fig|349747.3.peg.1047
- eggNOG:   COG1441
- HOGENOM:   HBG644552
- OMA:   YEANRDG
- ProtClustDB:   PRK05105
- BioCyc:   YPSE349747:YPSIP31758_1485-MONOMER
- HAMAP:   MF_00470
- InterPro:   IPR013342
- InterPro:   IPR010196
- SMART:   SM00922
- TIGRFAMs:   TIGR01927

Pfam domain/function: PF01188 MR_MLE

EC number: =4.2.1.113

Molecular weight: Translated: 35272; Mature: 35272

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: ACT_SITE 134-134 ACT_SITE 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQ
CCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
VAAECWLQHWVSGVESDDSVLPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
VLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLRLDANRSWSRAKADGFAKYVN
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
PALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCEEECCCCEEEEEECCHHH
GSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VRPWPDSPLPLITTEQLGVVWHR
CCCCCCCCCCEEEECCCCCEECC
>Mature Secondary Structure
MRTATLYRYSVPMEAGVILRHQRLKSRDGLLVKLQQGELSGWGEIAPLPEFSQETLDQAQ
CCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHH
VAAECWLQHWVSGVESDDSVLPSVAFGLSCAQAELNQTLPLSADYRKAPLCTGDPDELFA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
VLQALPGEKVAKVKVGLYEAVRDGMIVNVLLEALPDLTLRLDANRSWSRAKADGFAKYVN
HHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHC
PALRSRIAFLEEPCKTRAESREFAQDTGIAIAWDESVREADFQVEAEPGVAAIVIKPTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHCCCEEECCCCEEEEEECCHHH
GSLSRCQQLVQQAHQAGLVAVISSSIESSLGLTQLARLAAWLTPATVPGLDTLDLMQAQV
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
VRPWPDSPLPLITTEQLGVVWHR
CCCCCCCCCCEEEECCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA