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The map label for this gene is fghA [H]

Identifier: 153948145

GI number: 153948145

Start: 2794514

End: 2795356

Strand: Direct

Name: fghA [H]

Synonym: YpsIP31758_2474

Alternate gene names: 153948145

Gene position: 2794514-2795356 (Clockwise)

Preceding gene: 153947808

Following gene: 153947874

Centisome position: 59.16

GC content: 50.65

Gene sequence:

>843_bases
GTGAATACGTCACTTGAACTTCTCGAAGAGCATCGGATGTTTGGCGGCTGGCAACAGCGCTACCGCCATGCTGCCAGCAG
CCTGAATTGTCATATGACCTTCAGTATCTATCTGCCACCGCCACGGGACGATAACCCACCACCAGTCCTTTATTGGCTAT
CGGGCCTAACCTGTAATGATGAGAACTTTACGCTGAAAGCGGGCGCACAGCGGGTTGCCGCAGAACTCGGGCTGGTACTG
GTTATGCCTGATACCAGCCCCCGCGGTGATAATGTTCCCAACGATGACAGCTATGATTTAGGTCAGGGAGCGGGCTTCTA
CCTTAATGCGACGCAGGAGCCGTGGTCTGATCATTTCCAGATGTATGACTATATCAGCCAGGAATTGCCCTCACTGATCC
GCCAACATTTTAGTGTCAGTGAACGTCAATCAATCAGTGGTCATTCAATGGGCGGCCATGGTGCACTGATGCTAGCTCTG
CGTAATCCGCAACAATATCAGTCTGTTTCTGCTTTTGCGCCAATAGTTAACCCATGCCAAGTACCATGGGGCCGAAAAGC
CTTTACCGCTTATCTTGGCAGTGATGAAAACCAATGGCTGCAATATGATAGCTGCCATTTACTGACCCATGCACAGCATC
AGTTGCCTATATTGGTGGATCAGGGGGATGGTGATCAATTTCTTGCCGATCAACTCCAACCGGCAAAATTGGCGGAGCTG
GCGCGCCAGCGAGATTGGCCACTGACGTTGCGTATTCAGCCGGGTTATGATCACAGCTATTTTACCATAGCTACATTTAT
TGAAGATCACCTGCGCTTTCATGCTGCACACCTACAGCCGTAA

Upstream 100 bases:

>100_bases
ACGAAGCCTTTGATTTAATGCACGAGGGTAAATCTATCCGCAGTGTGATCCATTTTAATCACTCTTCCGAAAGCAAATAA
AGCAAGGAGGCAGACAAAAC

Downstream 100 bases:

>100_bases
CATTTGTCATTAGCCTAATTATTACACATAAAACCTCAAGCCCTTTCGAGGGCTTTTTATTCGATAGATAAAACCCCTCA
CATTAAAACCTCGTTTAAGA

Product: S-formylglutathione hydrolase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLTLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Sequences:

>Translated_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLTLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
>Mature_280_residues
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCNDENFTLKAGAQRVAAELGLVL
VMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQMYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLAL
RNPQQYQSVSAFAPIVNPCQVPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
ARQRDWPLTLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=280, Percent_Identity=51.0714285714286, Blast_Score=308, Evalue=4e-84,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=73.9130434782609, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1786551, Length=274, Percent_Identity=54.014598540146, Blast_Score=330, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI17510185, Length=281, Percent_Identity=46.9750889679715, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=43.7710437710438, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=49.1166077738516, Blast_Score=273, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24648347, Length=281, Percent_Identity=49.1103202846975, Blast_Score=271, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31750; Mature: 31750

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVNPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLTLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTSLELLEEHRMFGGWQQRYRHAASSLNCHMTFSIYLPPPRDDNPPPVLYWLSGLTCND
CCCHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCEEEEECCEEECC
ENFTLKAGAQRVAAELGLVLVMPDTSPRGDNVPNDDSYDLGQGAGFYLNATQEPWSDHFQ
CCEEEEHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHH
MYDYISQELPSLIRQHFSVSERQSISGHSMGGHGALMLALRNPQQYQSVSAFAPIVNPCQ
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCC
VPWGRKAFTAYLGSDENQWLQYDSCHLLTHAQHQLPILVDQGDGDQFLADQLQPAKLAEL
CCCCCHHEEEEECCCCCCEEEECCEEEEECCCCCCCEEEECCCCCHHHHHCCCHHHHHHH
ARQRDWPLTLRIQPGYDHSYFTIATFIEDHLRFHAAHLQP
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA