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The map label for this gene is iscS [H]

Identifier: 153947823

GI number: 153947823

Start: 2309013

End: 2310212

Strand: Direct

Name: iscS [H]

Synonym: YpsIP31758_2004

Alternate gene names: 153947823

Gene position: 2309013-2310212 (Clockwise)

Preceding gene: 153948168

Following gene: 153950371

Centisome position: 48.89

GC content: 52.42

Gene sequence:

>1200_bases
ATGTACAGTCAGAACCCACCGATATATCTCGATAATAACGCGACAACGGCACTAGACCCTGCCGTCCTGCAGGCGATGAT
GCCATACCTAACCCACGCTTATGGCAATGCCGCCAGTAAGAGCCACCCCTTTGGCTGGGAAGCGAGCCAGGCTGTTCAAC
GGGCCAGAACATTAATCGCAACCGCTATCAATGCAGTCAGTCCCGCCGATATCATCTTCACCTCTGGCGCGACAGAATCC
ATCAATCTTGCCATCTTAGGCCTTCAGTATCAGGGGAATTGGGGGCATATCATCACCTCCATGATTGAACACAAGTCAGT
TCTGGACTGCTGTGCCAAACTTGCCGACAGTGGGGTTAGTGTGACTTATCTGCAGCCACAGCGTGACGGTATTGTTTCCC
TTGATACCCTCTTCCAAGCTATCCGGCCCGATACGCGTCTGGTCTCAATCATGACTGCCAACAACGAGACAGGTACCTTG
CAAAAAGTGGCAGAAATTGGCGCACTCTGCCGGGATAAGGGCATTTTATTTCATACCGATGCCACACAGGCGTTCGGGAA
AATCGCTTTAGATATGCAACGGATGAATATCAGTATGGCCACTTTTTCCGCACATAAAGTTTACGGCCCCATGGGGGTCG
GGGCACTTTATGTCAATACCGCCGATCCGCATCTTATGCTTTCACCACTCATCGTTGGCGGAGGGCATGAGCGAGGTTTA
CGCTCCGGCACACTCAATGTACCGGGCATTGTCGGCTTTGGACGCGCCGCCGAACTGGCGATGGAAAACATGTCAGTAGA
ATCGGCCAGGCTATGTGATTTACGAAACAGGCTACGGCAGCACATTCTCGATACCGTACCGAATGTGCAGGTCAACGGCC
ACCTTACTGAATGCCTGCCCGGCGTGTTAAACGTGTCCTTTGAGGGTATCGATGCCGACTCGCTGTTGCTCGAACTCTCT
GACGTTGCCTTGTCCTCAGGATCCGCCTGCACCTCCGATCAACAGATACCATCACACGTGTTACAGGCTCTAGGGGCGAG
TGATGAGCAGATCCGGGGGAGTGTGCGCTTTGGACTCGGACGGTTTAATAACGAAAGTGAAATCGATTACGTCTGCCAGC
GTCTGGAAAATACGGTGAAAATGCTGAGATCAATGGCTCCGCTCTCATCTGCTACAACCACAAACGAGACAGGAGTCTGA

Upstream 100 bases:

>100_bases
GAGGCCGGTGAAGTCAGTCGGGGGGAGAAAATAATCGCTCAATTCACCTCTGCCCCAAAAAAGCCGTTGTCGTCTCGCTC
ATGATTAAGGAAAAATCATT

Downstream 100 bases:

>100_bases
ATCATGCGAAAAACTTCATCACTGTTTCTCCTGTTTGGCACGTTGTTCAGCGCAGGAGGCTATGGTGCCACATTTCTCAT
TTCTGCTTGGTTTCACTCGC

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAEIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGHERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGASDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV

Sequences:

>Translated_399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAEIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGHERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGASDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
>Mature_399_residues
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIATAINAVSPADIIFTSGATES
INLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVSVTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTL
QKVAEIGALCRDKGILFHTDATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGHERGL
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLPGVLNVSFEGIDADSLLLELS
DVALSSGSACTSDQQIPSHVLQALGASDEQIRGSVRFGLGRFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of ThiI in a transpersulfida

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=384, Percent_Identity=48.9583333333333, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI156713448, Length=417, Percent_Identity=34.7721822541966, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI48994898, Length=386, Percent_Identity=50.5181347150259, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787970, Length=317, Percent_Identity=27.7602523659306, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=25.1870324189526, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=385, Percent_Identity=45.4545454545455, Blast_Score=343, Evalue=8e-95,
Organism=Caenorhabditis elegans, GI17533177, Length=322, Percent_Identity=34.472049689441, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319831, Length=384, Percent_Identity=47.65625, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI20129463, Length=388, Percent_Identity=48.7113402061856, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010240
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 42803; Mature: 42803

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TAINAVSPADIIFTSGATESINLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVS
HHHHCCCCCCEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTLQKVAEIGALCRDKGILFHTD
EEEECCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECC
ATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGHERGL
HHHHHHHHHHHHHHHEEEEEEEEHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCC
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLP
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
GVLNVSFEGIDADSLLLELSDVALSSGSACTSDQQIPSHVLQALGASDEQIRGSVRFGLG
HHHCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHEECCC
RFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MYSQNPPIYLDNNATTALDPAVLQAMMPYLTHAYGNAASKSHPFGWEASQAVQRARTLIA
CCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
TAINAVSPADIIFTSGATESINLAILGLQYQGNWGHIITSMIEHKSVLDCCAKLADSGVS
HHHHCCCCCCEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTYLQPQRDGIVSLDTLFQAIRPDTRLVSIMTANNETGTLQKVAEIGALCRDKGILFHTD
EEEECCCCCCEEEHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECC
ATQAFGKIALDMQRMNISMATFSAHKVYGPMGVGALYVNTADPHLMLSPLIVGGGHERGL
HHHHHHHHHHHHHHHEEEEEEEEHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCCCCC
RSGTLNVPGIVGFGRAAELAMENMSVESARLCDLRNRLRQHILDTVPNVQVNGHLTECLP
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHH
GVLNVSFEGIDADSLLLELSDVALSSGSACTSDQQIPSHVLQALGASDEQIRGSVRFGLG
HHHCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHCCHHEECCC
RFNNESEIDYVCQRLENTVKMLRSMAPLSSATTTNETGV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA