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The map label for this gene is grxA [H]

Identifier: 153947544

GI number: 153947544

Start: 3002128

End: 3002391

Strand: Direct

Name: grxA [H]

Synonym: YpsIP31758_2648

Alternate gene names: 153947544

Gene position: 3002128-3002391 (Clockwise)

Preceding gene: 153949883

Following gene: 153948501

Centisome position: 63.56

GC content: 43.94

Gene sequence:

>264_bases
ATGTTTGCTGTGATTTTTGGACGTCCTGAGTGCCCTTACTGTGTCCGTGCCAAAGAGTTAGCTGAGAAACTGGCATCTGA
GCGTGACGATTTTAAATTCCGTTATGTCGACATTCATGCCGAAGGCATTTCCAAAGCTGATCTGGAAAAAACGGTCGGTA
AACCGGTTGAAACCGTGCCACAAATCTTTATTGATGAAAAACACATTGGCGGCTGTACTGATTTCGAAGCCTACGCCAAA
GAACATTTGAGCCTGTATAAGTAA

Upstream 100 bases:

>100_bases
CCCCAGTAAAAATGAGTAATACGCCAAATGTCATTTAACAGTTGAATATATCAGTAACTGTTGACGAAGTGATTATCTCA
ATTTAATCAAGGAGTTTTGC

Downstream 100 bases:

>100_bases
TCTGGCAGGCAACGTGGCAGTGACCGCATTTATCCGATAAGGGTGTCCAAGACACCCTTTCTTTATTGCTGGTATTTCGT
TCGGTGATAACCAAATAGTT

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1 [H]

Number of amino acids: Translated: 87; Mature: 87

Protein sequence:

>87_residues
MFAVIFGRPECPYCVRAKELAEKLASERDDFKFRYVDIHAEGISKADLEKTVGKPVETVPQIFIDEKHIGGCTDFEAYAK
EHLSLYK

Sequences:

>Translated_87_residues
MFAVIFGRPECPYCVRAKELAEKLASERDDFKFRYVDIHAEGISKADLEKTVGKPVETVPQIFIDEKHIGGCTDFEAYAK
EHLSLYK
>Mature_87_residues
MFAVIFGRPECPYCVRAKELAEKLASERDDFKFRYVDIHAEGISKADLEKTVGKPVETVPQIFIDEKHIGGCTDFEAYAK
EHLSLYK

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=83, Percent_Identity=69.8795180722892, Blast_Score=130, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9940; Mature: 9940

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAVIFGRPECPYCVRAKELAEKLASERDDFKFRYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFIDEKHIGGCTDFEAYAKEHLSLYK
HHHCCCCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MFAVIFGRPECPYCVRAKELAEKLASERDDFKFRYVDIHAEGISKADLEKTVGKPVETVP
CEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHCCCCHHHHH
QIFIDEKHIGGCTDFEAYAKEHLSLYK
HHHCCCCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]