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The map label for this gene is trpS [H]

Identifier: 153947109

GI number: 153947109

Start: 4442559

End: 4443599

Strand: Reverse

Name: trpS [H]

Synonym: YpsIP31758_3960

Alternate gene names: 153947109

Gene position: 4443599-4442559 (Counterclockwise)

Preceding gene: 153950156

Following gene: 153948211

Centisome position: 94.08

GC content: 48.32

Gene sequence:

>1041_bases
ATGAGTGAACCCATGGTATTAAGCAAACCCACTGTATCCAGTAAACCTATCGTATTCAGCGGCGCACAGCCGTCCGGCGA
ATTGACCATTGGTAATTACATGGGTGCGCTTCGTCAGTGGGTACAGATGCAGGATGATTATGATTGCATCTATTGCATTG
TTGACCTGCATGCAATTACGGCTCGCCAAGATCCGGCACTGTTGAGAAAAAGAACATTAGATACGCTGGCGCTGTATCTG
GCCTGCGGTATTGATCCGAAGAAGAGCACCATTTTTGTTCAATCCCATGTACCTGAACACTCTCAATTGAGCTGGGCGTT
GAACTGCTATACCTACTTTGGTGAACTGAGCCGCATGACCCAGTTCAAAGACAAGTCGGCGCGCTATGCAGAAAACATCA
ATGCGGGCTTGTTCGATTACCCGGTGTTGATGGCGGCAGATATTTTACTGTATCAAACCAACCAGGTACCGGTGGGGGAA
GACCAAAAGCAGCATTTGGAGCTGAGCCGCGATATTGCGAGTCGTTTCAATAATCTGTATGGCGATATTTTTAAAATCCC
TGAGCCGTTTATTCCTAAAGCTGGCGCCCGCGTCATGTCTTTACAGGATCCGACCAAGAAAATGTCTAAATCGGATGACA
ACCGTAACAATGTGATCGAGTTACTGGAAGATCCTAAATCGGTGGTTAAAAAGATTAAGCGTGCCATGACAGACTCTGAT
GAACCTGCGCTCATTCGTTATGATGTAGAGAAAAAAGCCGGCGTGTCTAATTTGCTGGATATTCTGTCTGGTGTGACCGG
TCAATCGATCCCAGAGCTGGAAGCGCAGTTTACTGGCCAGATGTACGGTCATTTGAAAGGAGCGGTGGCAGATGCCGTTT
CTGGCATGTTGAGCGAGCTACAAGAGCGTTATCGTACTTATCGTGAAGATGAGGCGTTGTTGCAAGATGTGATGCGTGAA
GGTGCCGCCAAGGCCCGTACCCGCGCACAAGTAACCTTGGCTAAAGTGTACGAAGCCATCGGTTTTGTCGCGCAGCCGTA
A

Upstream 100 bases:

>100_bases
GAAGCGATTGCCACCAGTCATCCAGACTGCGTGCTGGCGCATTTTGCCGACCTGTTGCCCGCCATTGGGCTACCATCTTT
AAAAGATCAGGAAGTATAAA

Downstream 100 bases:

>100_bases
CGATCACAACGCATCAGTAATGTGAGGGGGAAATTTCCCCCTCATTAATCAGCATTAACCCATATTACTCACACAGCCAG
CCTTAACTGCATAGCTAACC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSEPMVLSKPTVSSKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCIYCIVDLHAITARQDPALLRKRTLDTLALYL
ACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGE
DQKQHLELSRDIASRFNNLYGDIFKIPEPFIPKAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSD
EPALIRYDVEKKAGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSELQERYRTYREDEALLQDVMRE
GAAKARTRAQVTLAKVYEAIGFVAQP

Sequences:

>Translated_346_residues
MSEPMVLSKPTVSSKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCIYCIVDLHAITARQDPALLRKRTLDTLALYL
ACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGE
DQKQHLELSRDIASRFNNLYGDIFKIPEPFIPKAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSD
EPALIRYDVEKKAGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSELQERYRTYREDEALLQDVMRE
GAAKARTRAQVTLAKVYEAIGFVAQP
>Mature_345_residues
SEPMVLSKPTVSSKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCIYCIVDLHAITARQDPALLRKRTLDTLALYLA
CGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGED
QKQHLELSRDIASRFNNLYGDIFKIPEPFIPKAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSDE
PALIRYDVEKKAGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSELQERYRTYREDEALLQDVMREG
AAKARTRAQVTLAKVYEAIGFVAQP

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=43.202416918429, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=53.072625698324, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1789786, Length=333, Percent_Identity=84.984984984985, Blast_Score=597, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71982800, Length=349, Percent_Identity=35.243553008596, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71982793, Length=349, Percent_Identity=35.243553008596, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=356, Percent_Identity=39.0449438202247, Blast_Score=234, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24666151, Length=329, Percent_Identity=43.4650455927052, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 38700; Mature: 38569

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPMVLSKPTVSSKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCIYCIVDLHAIT
CCCCCEEECCCCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHH
ARQDPALLRKRTLDTLALYLACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIASRFNNLY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
GDIFKIPEPFIPKAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSD
HHHHCCCCCCCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
EPALIRYDVEKKAGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSEL
CCEEEEECCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERYRTYREDEALLQDVMREGAAKARTRAQVTLAKVYEAIGFVAQP
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEPMVLSKPTVSSKPIVFSGAQPSGELTIGNYMGALRQWVQMQDDYDCIYCIVDLHAIT
CCCCEEECCCCCCCCEEEECCCCCCCEEHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHH
ARQDPALLRKRTLDTLALYLACGIDPKKSTIFVQSHVPEHSQLSWALNCYTYFGELSRMT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIASRFNNLY
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHH
GDIFKIPEPFIPKAGARVMSLQDPTKKMSKSDDNRNNVIELLEDPKSVVKKIKRAMTDSD
HHHHCCCCCCCCCCCCEEEECCCHHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHCCCC
EPALIRYDVEKKAGVSNLLDILSGVTGQSIPELEAQFTGQMYGHLKGAVADAVSGMLSEL
CCEEEEECCHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QERYRTYREDEALLQDVMREGAAKARTRAQVTLAKVYEAIGFVAQP
HHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]