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The map label for this gene is wecG

Identifier: 153946840

GI number: 153946840

Start: 218360

End: 219100

Strand: Direct

Name: wecG

Synonym: YpsIP31758_0193

Alternate gene names: 153946840

Gene position: 218360-219100 (Clockwise)

Preceding gene: 153948608

Following gene: 153949165

Centisome position: 4.62

GC content: 51.82

Gene sequence:

>741_bases
ATGGAACCCAATACTGTCATTCCAAAATATAATGTCCGTGGCTTTGAAATCTGGGGTTTTCGTGACATGGCTCAGGTGCT
GGATCATCTACTGGGCAGTGGGCCGGTAAAAACGGGCACCTTGGTGGCGATGAATGCGGAAAAGCTATTAAAAGCCGAAG
ATGATACTGCACTGTGTGAACTGATCAAGAACGCGGAGTATCTGTACGCAGATGGCATCAGTATGGTTCGGGCTATCCGC
CGTAAATATCCGCAGGCCGAGCTATCACGCGTTGCGGGTGCTGACCTCTGGGAAGCCCTGATGCAGCGCGCTGGGCAGCA
AGGGACGCCAGTATTTTTGGTTGGCGGTAAGCCTGATGTATTGGCTGAAACCGAGGCGAAATTGCGTGCCCAATGGAACG
TGAATTTAGTCGGTAGCCAAGATGGCTATTTCACACCGGAGCAGCGTGAAGCCCTGTTTGCCCGTATTGCCGCCAGTGGT
GCAGCAATTGTCACTGTCGCCATGGGGTCTCCTAAACAGGAGATCTTCATGCGTGACTGCCGTAAATTTTACCCTGATGC
CCTGTATATGGGGGTTGGCGGCACTTACGATGTTTTCACCGGCCATGTCAAACGTGCCCCCAAAATTTGGCAGAATATGG
GGCTGGAGTGGTTATACCGGTTGCTGGCGCAACCCAGCCGCATTCGTCGTCAGCTTAAGCTGCTTAAGTTTGTTGGTTAT
TATTATAGTGGTCGTCTGTAG

Upstream 100 bases:

>100_bases
TGTACTGGTTGTTCGATACGGCGGGTTTGATAAAGCGTCAGGGGATTAAATCCAACCGATTATCAATGCCTAACGCGGGC
AATCAACTGTAAGGATTGTA

Downstream 100 bases:

>100_bases
TGTTTTGTTCTTAGTCGCGCCCCTTCTTACCTTGACGCCGCAGCGGTTAGCGGCGTCACTCAGTTGAATCACTTCACTTC
ACTTCACTTCACAGCTCTGC

Product: UDP-N-acetyl-D-mannosaminuronic acid transferase

Products: C55-PP-GlcNAc-ManNAcA; UDP [C]

Alternate protein names: UDP-ManNAcA transferase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCELIKNAEYLYADGISMVRAIR
RKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDVLAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASG
AAIVTVAMGSPKQEIFMRDCRKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGY
YYSGRL

Sequences:

>Translated_246_residues
MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCELIKNAEYLYADGISMVRAIR
RKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDVLAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASG
AAIVTVAMGSPKQEIFMRDCRKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGY
YYSGRL
>Mature_246_residues
MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCELIKNAEYLYADGISMVRAIR
RKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDVLAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASG
AAIVTVAMGSPKQEIFMRDCRKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGY
YYSGRL

Specific function: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in ECA synthesis

COG id: COG1922

COG function: function code M; Teichoic acid biosynthesis proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 26 family

Homologues:

Organism=Escherichia coli, GI2367289, Length=246, Percent_Identity=71.1382113821138, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WECG_YERP3 (A7FD62)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001399190.1
- STRING:   A7FD62
- GeneID:   5386545
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_0193
- eggNOG:   COG1922
- HOGENOM:   HBG685240
- OMA:   ENFIQNN
- ProtClustDB:   PRK03692
- BioCyc:   YPSE349747:YPSIP31758_0193-MONOMER
- HAMAP:   MF_01001
- InterPro:   IPR023085
- InterPro:   IPR004629
- TIGRFAMs:   TIGR00696

Pfam domain/function: PF03808 Glyco_tran_WecB

EC number: 2.4.1.- [C]

Molecular weight: Translated: 27646; Mature: 27646

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCE
CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCHHHHHH
LIKNAEYLYADGISMVRAIRRKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDV
HHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCC
LAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASGAAIVTVAMGSPKQEIFMRDC
CHHHHHHHEEEECEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGY
HHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
YYSGRL
HHCCCC
>Mature Secondary Structure
MEPNTVIPKYNVRGFEIWGFRDMAQVLDHLLGSGPVKTGTLVAMNAEKLLKAEDDTALCE
CCCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHCCCCHHHHHH
LIKNAEYLYADGISMVRAIRRKYPQAELSRVAGADLWEALMQRAGQQGTPVFLVGGKPDV
HHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCC
LAETEAKLRAQWNVNLVGSQDGYFTPEQREALFARIAASGAAIVTVAMGSPKQEIFMRDC
CHHHHHHHEEEECEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHH
RKFYPDALYMGVGGTYDVFTGHVKRAPKIWQNMGLEWLYRLLAQPSRIRRQLKLLKFVGY
HHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHH
YYSGRL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosaminuronic-acid; undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate [C]

Specific reaction: UDP-N-acetyl-D-mannosaminuronic-acid + undecaprenyl-N-acetyl-alpha-D-glucosaminyl-pyrophosphate = C55-PP-GlcNAc-ManNAcA + UDP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA