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The map label for this gene is ttcA [H]

Identifier: 153937030

GI number: 153937030

Start: 3380317

End: 3381066

Strand: Direct

Name: ttcA [H]

Synonym: CLC_3239

Alternate gene names: 153937030

Gene position: 3380317-3381066 (Clockwise)

Preceding gene: 153936500

Following gene: 153934762

Centisome position: 89.89

GC content: 27.2

Gene sequence:

>750_bases
TTGATTATATTTGAAAAAAACTACAATAAGATATTTTTAAAGTATGTAAGAAGAGCTATAGATGACTATAATATGATATC
CCCAAGAGACAAAATCGCTGTAGCTGTTTCTGGTGGTAAAGATAGCATCTTCTTGTTATTTTGTTTAAAGCTAATACAAT
TAACAGCTATAAAAGATATTGAAATAGTAGCTATTCATGTAGACTTAGGCCTAAATATGGATCTAGAACCATTAAAAATT
TTTTGCAAGAAAAATAGCATAGACTTAGTAATAGAAAAAACCAATATTGCAAATGTAGTATTCAATGAAAGAAAAGAAAA
AAATCCATGTTCCCTTTGTTCTAAACTAAGAAAAGGTTGCCTTGTAAGAGTTTCTAAATCCATAGGTGCCACAAAAATAG
CTCTTGGTCATAATTGTGATGATGTAATAGAAACTTTATTTATGAATGTTTTAAAAATTGGTAAATTTGGGTCTTTTAGT
CCCCATATAGATTACAAAGATAAATATGTACATATAATCAGACCTTTAATATATTTAAGAGAAGATCTTATTAAGAATTT
GGTAAAAAAACACAATTTACCTGTGGTTAAAAGTACTTGTCCTGAGGATAAAAAGACTACTAGAGAAGAAATGAAAAATT
TAATGTTTAAGCTAGAAGAAACTTACCCTAAAGCTATAGATAGACTTATGACCTCCCTATGTAATATAGATATGAAAAAT
CTTTGGAAACAAAGAGATAATAATTTTTAA

Upstream 100 bases:

>100_bases
TGAAAATCTATTTAATATTATTATAAAATCTATTTATATCTACTATTTAGTATTGTAAATTATATATGTTTTTATGTAAA
TTGAGAAAGGGGTTATTTTA

Downstream 100 bases:

>100_bases
TAATAAAAATGATATCATATTAACTACAAAAATAAAAATAAGAAACTCTATATAAAGAGTCTCTTATTTTTATTTTCATT
AATACATTCCATCCATTCCC

Product: PP-loop family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLNMDLEPLKI
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFS
PHIDYKDKYVHIIRPLIYLREDLIKNLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNNF

Sequences:

>Translated_249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLNMDLEPLKI
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFS
PHIDYKDKYVHIIRPLIYLREDLIKNLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNNF
>Mature_249_residues
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDIEIVAIHVDLGLNMDLEPLKI
FCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGCLVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFS
PHIDYKDKYVHIIRPLIYLREDLIKNLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
LWKQRDNNF

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=226, Percent_Identity=33.1858407079646, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193211090, Length=227, Percent_Identity=29.9559471365639, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17540090, Length=236, Percent_Identity=24.5762711864407, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=26.4957264957265, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 28816; Mature: 28816

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDI
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCE
EIVAIHVDLGLNMDLEPLKIFCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGC
EEEEEEEECCCCCCHHHHHHEEECCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFSPHIDYKDKYVHIIRPLIYLR
EEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDLIKNLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
HHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LWKQRDNNF
HHHHHCCCC
>Mature Secondary Structure
MIIFEKNYNKIFLKYVRRAIDDYNMISPRDKIAVAVSGGKDSIFLLFCLKLIQLTAIKDI
CEEEECCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCE
EIVAIHVDLGLNMDLEPLKIFCKKNSIDLVIEKTNIANVVFNERKEKNPCSLCSKLRKGC
EEEEEEEECCCCCCHHHHHHEEECCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHHH
LVRVSKSIGATKIALGHNCDDVIETLFMNVLKIGKFGSFSPHIDYKDKYVHIIRPLIYLR
EEHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
EDLIKNLVKKHNLPVVKSTCPEDKKTTREEMKNLMFKLEETYPKAIDRLMTSLCNIDMKN
HHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LWKQRDNNF
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA