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The map label for this gene is lexA [H]

Identifier: 153936900

GI number: 153936900

Start: 988435

End: 990042

Strand: Direct

Name: lexA [H]

Synonym: CLC_0963

Alternate gene names: 153936900

Gene position: 988435-990042 (Clockwise)

Preceding gene: 153935802

Following gene: 153934642

Centisome position: 26.28

GC content: 26.37

Gene sequence:

>1608_bases
ATGAAGCTAGAAAGTGGACAAAATAGAATAGCTAAAAGTAAACATTTAGGATACGGATTATTAAGAGGATCAAAAGGTAC
TGGAAAAACTACTGCAGCTATATATAGAGGTATTTATTTAAAAAATCAATATTGTATGTATGATAAAGATAAAGTATTAA
TACTATCAAAGAATGAAGAAAATTTAAACTATATTAAGAACATATATAATGATGCAGAAAAAACAGGGGTTCAATACATT
ACTTTATTTTCGTATAATGAGGACAAGCTACATTTTAGTAGTATATATAAAATTATAAACAAGTATTTTTGGGAGTACAT
AGAAAATAACAATTTACAATATGAGCTGGCAAGTGAAAAAGAAAAACTAGCTATAATTGAAGAATGTATAAATGATATAA
AAAATGAATACAAAAATTTAAAATATATAGATATAAAATATAGTAAATTCTTTTTAGAAGAAATACAATGGATGAAAGAC
TGTATGTATTATGATTTAGAAGAATATAAAAAAGCAGATAGAATAGGTAGAAAAACAAAAAAAGGTGAAGGTCCTCAAAG
AATTATAAAAAATTCAAAAATTAGAGAAGCAGTATTTAAAATTATGCTTTTATATAATGAAAAGTTAAAGTATAAAAATT
TGGTAGACTACAGTGATGTAGTATCTATGTCCTTAAAAGAAGCTTCCAAAAATAAAGAAAATAAATTTAATCACATAATA
GTAGATGAGGCACAAAATTTTACTAAACTAGAATTAAAATTTATAGAAGCTTTAGGAAGAAAAAATATATATTCAAGCAT
ACTATTTATTGCAGATAAAGAGAAAAATTCAAATCCTAAAGGATGGATAACTAAGGGACGGAAATTAAATAATCTTCAAT
TAGGGTTTGAATTTAAAAGATTTAATTTGAATAAAAAAATAGGTATTAATGTAAAAGAAGAAGTAGAAACATATATAGAT
GATTGCAATCTTAAAAGAAAAGCTTCAAATATTAATACAAAAAATGAAGATGTTTCGAATGTAGATAACTCTAATTCAGA
AGATAAGGGTTTAGATAAAAACATTAAAAATGAATGGCATAAAGATAAGGTAAATTATGATATGGATAAGTTTGAATATG
TAGATATGAAACACAGAAGATCTTATGAATTTTCTAGAGGCTTAGGTAGCAATGAAGAAATTATTGTAGAAGATCAAGGG
AGCAAAGAAGAGTACAAAGAGGATGAGTTAACAAAACTCCCAGTATTTAATGATATAGCGGCAGGAGAGCCTATACTTAT
GAATCCTTGTGTAGAAGGAGAATTTAATATACCTAAATATTGGGTAAGGGGTATGAAAAATTGCTTCATATTAAAGGTAA
AAGGGGATAGTATGATAGGTGCTAACATAGAAGATGGAGATCATGTGGTAATAAAGAGGCAGCAAATGGCTGAAAATAAA
GATATAGTAGCTGTTAACTTAGATGGAAGCGCAACCCTTAAAAGATTATTAATAAAAAAATCTGGAGCAGTACTTATGCC
AGAAAATAAAAAATATAAACCGATTGAAATATTAGAAGAGGGAGCAAGCATTATAGGAATAGCAGTGGGAATAATAAAAG
GGAAATAG

Upstream 100 bases:

>100_bases
TGCAATGGCATTGCTATTATAATAATTAAAATTTTGGCTAAAGTATAAGGTATTATATATAATGTTTTAGGGTAAAGAAT
TAGATAAGGAGGTGAAGAAA

Downstream 100 bases:

>100_bases
CAATATATAATTATTGAACTGCCTTATATTTGTTATAATATAATAAATATAAGGCAGTTTTTTGTTAATATGCTTTTTAA
AAAAGAGAAGATTATGCTTA

Product: putative LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKLESGQNRIAKSKHLGYGLLRGSKGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENLNYIKNIYNDAEKTGVQYI
TLFSYNEDKLHFSSIYKIINKYFWEYIENNNLQYELASEKEKLAIIEECINDIKNEYKNLKYIDIKYSKFFLEEIQWMKD
CMYYDLEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKYKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKIGINVKEEVETYID
DCNLKRKASNINTKNEDVSNVDNSNSEDKGLDKNIKNEWHKDKVNYDMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQG
SKEEYKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENK
DIVAVNLDGSATLKRLLIKKSGAVLMPENKKYKPIEILEEGASIIGIAVGIIKGK

Sequences:

>Translated_535_residues
MKLESGQNRIAKSKHLGYGLLRGSKGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENLNYIKNIYNDAEKTGVQYI
TLFSYNEDKLHFSSIYKIINKYFWEYIENNNLQYELASEKEKLAIIEECINDIKNEYKNLKYIDIKYSKFFLEEIQWMKD
CMYYDLEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKYKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKIGINVKEEVETYID
DCNLKRKASNINTKNEDVSNVDNSNSEDKGLDKNIKNEWHKDKVNYDMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQG
SKEEYKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENK
DIVAVNLDGSATLKRLLIKKSGAVLMPENKKYKPIEILEEGASIIGIAVGIIKGK
>Mature_535_residues
MKLESGQNRIAKSKHLGYGLLRGSKGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEENLNYIKNIYNDAEKTGVQYI
TLFSYNEDKLHFSSIYKIINKYFWEYIENNNLQYELASEKEKLAIIEECINDIKNEYKNLKYIDIKYSKFFLEEIQWMKD
CMYYDLEEYKKADRIGRKTKKGEGPQRIIKNSKIREAVFKIMLLYNEKLKYKNLVDYSDVVSMSLKEASKNKENKFNHII
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKRFNLNKKIGINVKEEVETYID
DCNLKRKASNINTKNEDVSNVDNSNSEDKGLDKNIKNEWHKDKVNYDMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQG
SKEEYKEDELTKLPVFNDIAAGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENK
DIVAVNLDGSATLKRLLIKKSGAVLMPENKKYKPIEILEEGASIIGIAVGIIKGK

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=131, Percent_Identity=34.3511450381679, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787431, Length=128, Percent_Identity=28.90625, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 62225; Mature: 62225

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLESGQNRIAKSKHLGYGLLRGSKGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEE
CCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHEEEECCEEEECCCEEEEEECCCC
NLNYIKNIYNDAEKTGVQYITLFSYNEDKLHFSSIYKIINKYFWEYIENNNLQYELASEK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
EKLAIIEECINDIKNEYKNLKYIDIKYSKFFLEEIQWMKDCMYYDLEEYKKADRIGRKTK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKYKNLVDYSDVVSMSLKEASKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEECCCEECCEEEEEEEEE
FNLNKKIGINVKEEVETYIDDCNLKRKASNINTKNEDVSNVDNSNSEDKGLDKNIKNEWH
ECCCCEECCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KDKVNYDMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEEYKEDELTKLPVFNDIA
HCCCCCCCCHHHHHCHHHHCCCHHHCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCC
AGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENK
CCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCEECCCCCCCCEEEEEEHHHCCCC
DIVAVNLDGSATLKRLLIKKSGAVLMPENKKYKPIEILEEGASIIGIAVGIIKGK
CEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCEEEEEEEEEECC
>Mature Secondary Structure
MKLESGQNRIAKSKHLGYGLLRGSKGTGKTTAAIYRGIYLKNQYCMYDKDKVLILSKNEE
CCCCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHHEEEECCEEEECCCEEEEEECCCC
NLNYIKNIYNDAEKTGVQYITLFSYNEDKLHFSSIYKIINKYFWEYIENNNLQYELASEK
HHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
EKLAIIEECINDIKNEYKNLKYIDIKYSKFFLEEIQWMKDCMYYDLEEYKKADRIGRKTK
HHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCC
KGEGPQRIIKNSKIREAVFKIMLLYNEKLKYKNLVDYSDVVSMSLKEASKNKENKFNHII
CCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEE
VDEAQNFTKLELKFIEALGRKNIYSSILFIADKEKNSNPKGWITKGRKLNNLQLGFEFKR
EECCCCCHHHHHHHHHHHCCCCHHHEEEEEEECCCCCCCCCCEECCCEECCEEEEEEEEE
FNLNKKIGINVKEEVETYIDDCNLKRKASNINTKNEDVSNVDNSNSEDKGLDKNIKNEWH
ECCCCEECCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KDKVNYDMDKFEYVDMKHRRSYEFSRGLGSNEEIIVEDQGSKEEYKEDELTKLPVFNDIA
HCCCCCCCCHHHHHCHHHHCCCHHHCCCCCCCEEEEECCCCHHHHCCCCCEECCCCCCCC
AGEPILMNPCVEGEFNIPKYWVRGMKNCFILKVKGDSMIGANIEDGDHVVIKRQQMAENK
CCCCEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCEECCCCCCCCEEEEEEHHHCCCC
DIVAVNLDGSATLKRLLIKKSGAVLMPENKKYKPIEILEEGASIIGIAVGIIKGK
CEEEEECCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA