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The map label for this gene is (tetP [H]

Identifier: 153936842

GI number: 153936842

Start: 2171151

End: 2173106

Strand: Reverse

Name: (tetP [H]

Synonym: CLC_2046

Alternate gene names: 153936842

Gene position: 2173106-2171151 (Counterclockwise)

Preceding gene: 153936073

Following gene: 153934595

Centisome position: 57.79

GC content: 29.14

Gene sequence:

>1956_bases
ATGAATAAGACAATAGGAATATTAGCACATGTAGATGCGGGAAAAACCACATTTGCAGAACAAATATTATATCATACAAA
AAGTATCAAAAGTAGAGGAAGAGTGGATCATAAAAGCTCTTTTTTAGATAATCATAAAATTGAAAAAGAAAGAGGAATAA
CAGTATTTTCAGAGCAGGGAACCTTTCAGTATAAAGATTCTACATACTATCTTATAGATACTCCAGGACATATGGATTTT
TCATCTGAAATGGAAAGAGCCATTAAAGTTATGGATTATGCTGTAATTATAATAAGTGGAGTTGAAGGAATACAAGGACA
TACAGAAACAGTATGGAATCTTTTAAGAAAGCACAATATTCCTGTTCTTTTTTTCATAAATAAAATAGATAGAGTAGGAG
CTAATGCCGAAAATGTAATTGAAGAAATAAAGCTTAATTTTACTAAAAAGGCTTTTTTTATTGATAAATCATTAAGTAAT
GAAGAGTGTTCATCTGAGCTTATAGAATTTATTGCAGAGCAGGACGAATGTCTTTTAGAGAAATATTTAGAAGATAATTA
TGATAAAGAGTTATGGTTAAATTCTATGAAGAAACTTATTAAATCAAATAAGATTTTTCCTTGTTTTTCAGGTTCAGCAT
TACAGGATATAGGCATAGAAGAGTTTTTAGAAAATCTACATACTTTAAGCTATACAGAATACAATGAAGAAGAAAAATTT
AGTGGAAGAGTATATAAAATACGCCACGATGAACAAAAAAATAGATTAACCTATGTAAAGGCATTAAGTGGTAGCTTAAA
GGTGAAAGACGAAATAGCTTTACCTAATATTGAAGATGATTTTTGTGAGAAGGTTAATGAGATAAGAATATATAATGGTG
ATAAATATATAAATGTAGATAAAGCTGAAGCGGGACAGATTTTTGCAGTAACAGGTCTAAATTCTGCTAATGTAGGTGAT
GGAATTGGAACTTTAAAAGATAAAGCTACATATAATATGGTTCCCACTTTAAAATCAAAAGTTATATTTGATGAAACATT
AAATGTAAAAGACGTTTTAAGGTATTTTAAAATTTTAGAAGCAGAAGATCCTTCTTTAAATATAATTTGGAATGAAAAAT
TTCAAGAAATTCAAGTTTATATTATGGGTGTTATCCAATTAGAAGTTTTAAAGAATTTGATGGAAGAAAGATTTCATATA
TCAATAGATTTTGGCCCTTGTGAAATATTATATAAGGAAACTATTTTAGATACAGTAATAGGATATGGTCATTTTGAACC
TTTAGGACACTACTCAGAAGTCCATTTTAAATTAGAGCCAGGGGAGCGAAATAGTGGTATTACATTTGAAAATTTATGCC
ATACAGATGATTTAACAGTAGGAAATCAAAATTTAGTAAGAACTCACATTTTTGAAAGAGAGCATCATGGAATTTTAACA
GGCTCTCCTATAACAGATATAAATATAACACTTTTAACTGGAAGGGCACATAATAAACATACCAGCGGAGGAGATTTTAG
GGAAGCTACCTTTAGGGCTTTAAGACAAGGATTAGAAAAGGCTAAAAACGTATTATTAGAGCCTTATTATTCTTTTAAAA
TGGAAGTACCATTAGATTGTATGGGAAGAGTCTTATCAGATATACAAAAGTTAAAGGGCTCTTTTAATCCTCCAGAAACA
ATTGAGAATAGAGTTATTATAAAAGGAAGAGGACCCGTTGCAACATTTATGAATTATAGTGTGGAGTTTATTTCTTTTAC
TAAGGGAAAGGGTAAATTTAATTTCATATTTGATGGATACGATATTTGCCATAATGAAAAAGATATTATAGAAAAGATAG
CCTATGATAAAAATGCAGACATTGAATATACTTCAACTTCAATCTTCTGTTCTAAAGGACAAGCATTTCTAGTTAAGTAT
GATGAAGCAGATGGATATATGCATTGTTTGAAATAG

Upstream 100 bases:

>100_bases
AATAATTTGTTATTATAAAGTTATGTTTCTGGCTTAAATAGCTTATTCTGTGGTAATATAATAGTGTCATTAGAATGAAA
ATTACAATAGGAGATATATT

Downstream 100 bases:

>100_bases
ATTTTAGTTTGTAGAAGGGCACTTGAAAGAGTACTAGTTTATAATTTTAGCAAATGGCTCAAATCTATGGAAAAAATGCA
GAATATGCAAGCATTATAAA

Product: putative tetracycline resistance protein

Products: NA

Alternate protein names: TetB(P) [H]

Number of amino acids: Translated: 651; Mature: 651

Protein sequence:

>651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQGTFQYKDSTYYLIDTPGHMDF
SSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSN
EECSSELIEFIAEQDECLLEKYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKF
SGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVDKAEAGQIFAVTGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHI
SIDFGPCEILYKETILDTVIGYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILT
GSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKY
DEADGYMHCLK

Sequences:

>Translated_651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQGTFQYKDSTYYLIDTPGHMDF
SSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSN
EECSSELIEFIAEQDECLLEKYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKF
SGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVDKAEAGQIFAVTGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHI
SIDFGPCEILYKETILDTVIGYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILT
GSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKY
DEADGYMHCLK
>Mature_651_residues
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQGTFQYKDSTYYLIDTPGHMDF
SSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNIPVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSN
EECSSELIEFIAEQDECLLEKYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKF
SGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVDKAEAGQIFAVTGLNSANVGD
GIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILEAEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHI
SIDFGPCEILYKETILDTVIGYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILT
GSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDCMGRVLSDIQKLKGSFNPPET
IENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGYDICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKY
DEADGYMHCLK

Specific function: Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes [H]

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TetM/tetO subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923640, Length=696, Percent_Identity=26.0057471264368, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI18390331, Length=698, Percent_Identity=25.7879656160458, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI25306287, Length=659, Percent_Identity=26.2518968133536, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI25306283, Length=382, Percent_Identity=29.0575916230367, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI94966754, Length=134, Percent_Identity=37.3134328358209, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI157426893, Length=149, Percent_Identity=34.8993288590604, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=32.8767123287671, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI310132016, Length=106, Percent_Identity=36.7924528301887, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI310110807, Length=106, Percent_Identity=36.7924528301887, Blast_Score=73, Evalue=8e-13,
Organism=Homo sapiens, GI310123363, Length=106, Percent_Identity=36.7924528301887, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1789738, Length=691, Percent_Identity=27.2069464544139, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1790835, Length=457, Percent_Identity=23.1947483588621, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI48994988, Length=141, Percent_Identity=31.2056737588652, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788922, Length=147, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790412, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1789737, Length=127, Percent_Identity=30.7086614173228, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17533571, Length=689, Percent_Identity=25.2539912917271, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17556745, Length=677, Percent_Identity=25.2584933530281, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17557151, Length=142, Percent_Identity=34.5070422535211, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988819, Length=130, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988811, Length=130, Percent_Identity=34.6153846153846, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17506493, Length=175, Percent_Identity=28, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17552882, Length=135, Percent_Identity=32.5925925925926, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=701, Percent_Identity=27.1041369472183, Blast_Score=213, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6322359, Length=515, Percent_Identity=26.6019417475728, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6323320, Length=151, Percent_Identity=32.4503311258278, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324707, Length=145, Percent_Identity=32.4137931034483, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320593, Length=145, Percent_Identity=32.4137931034483, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324166, Length=205, Percent_Identity=30.7317073170732, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24582462, Length=684, Percent_Identity=25.4385964912281, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221458488, Length=697, Percent_Identity=23.9598278335725, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI78706572, Length=149, Percent_Identity=36.241610738255, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28574573, Length=139, Percent_Identity=35.2517985611511, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585709, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585711, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585713, Length=167, Percent_Identity=29.940119760479, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550900, Length=181, Percent_Identity=31.4917127071823, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR002127
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 74586; Mature: 74586

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCEEEECCC
TFQYKDSTYYLIDTPGHMDFSSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
EEEECCCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSNEECSSELIEFIAEQDECLLE
CEEEEEECHHHCCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHH
KYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHCCHHHHHHHHHHCEECCCCCCHHH
SGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVD
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHCCEEEECCCEEEEEC
KAEAGQIFAVTGLNSANVGDGIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCEEECCCCCHHHHHHHHHHHC
AEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHISIDFGPCEILYKETILDTVI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
GSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHH
MGRVLSDIQKLKGSFNPPETIENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGY
HHHHHHHHHHHCCCCCCCHHHCCEEEEECCCCHHHHHCCEEEEEEEECCCCEEEEEECCH
DICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKYDEADGYMHCLK
HHHCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCEEEEEEECCCCEEEECC
>Mature Secondary Structure
MNKTIGILAHVDAGKTTFAEQILYHTKSIKSRGRVDHKSSFLDNHKIEKERGITVFSEQG
CCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHCCCEEEECCC
TFQYKDSTYYLIDTPGHMDFSSEMERAIKVMDYAVIIISGVEGIQGHTETVWNLLRKHNI
EEEECCCEEEEEECCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHCCC
PVLFFINKIDRVGANAENVIEEIKLNFTKKAFFIDKSLSNEECSSELIEFIAEQDECLLE
CEEEEEECHHHCCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHHHCCHHHHHH
KYLEDNYDKELWLNSMKKLIKSNKIFPCFSGSALQDIGIEEFLENLHTLSYTEYNEEEKF
HHHHCCCCHHHHHHHHHHHHHCCCCCEEECCCCHHHCCHHHHHHHHHHCEECCCCCCHHH
SGRVYKIRHDEQKNRLTYVKALSGSLKVKDEIALPNIEDDFCEKVNEIRIYNGDKYINVD
CCCEEEEECCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHCCEEEECCCEEEEEC
KAEAGQIFAVTGLNSANVGDGIGTLKDKATYNMVPTLKSKVIFDETLNVKDVLRYFKILE
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHCEEECCCCCHHHHHHHHHHHC
AEDPSLNIIWNEKFQEIQVYIMGVIQLEVLKNLMEERFHISIDFGPCEILYKETILDTVI
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHH
GYGHFEPLGHYSEVHFKLEPGERNSGITFENLCHTDDLTVGNQNLVRTHIFEREHHGILT
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCEEE
GSPITDINITLLTGRAHNKHTSGGDFREATFRALRQGLEKAKNVLLEPYYSFKMEVPLDC
CCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEECCCHHH
MGRVLSDIQKLKGSFNPPETIENRVIIKGRGPVATFMNYSVEFISFTKGKGKFNFIFDGY
HHHHHHHHHHHCCCCCCCHHHCCEEEEECCCCHHHHHCCEEEEEEEECCCCEEEEEECCH
DICHNEKDIIEKIAYDKNADIEYTSTSIFCSKGQAFLVKYDEADGYMHCLK
HHHCCCHHHHHHHHCCCCCCEEEEEEEEEEECCCEEEEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8170402 [H]