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The map label for this gene is galE [C]

Identifier: 153934595

GI number: 153934595

Start: 2165580

End: 2166503

Strand: Reverse

Name: galE [C]

Synonym: CLC_2043

Alternate gene names: 153934595

Gene position: 2166503-2165580 (Counterclockwise)

Preceding gene: 153936842

Following gene: 153935655

Centisome position: 57.61

GC content: 27.27

Gene sequence:

>924_bases
ATGAAGGTATTAGTTAGTGGTGGTGCAGGATTTATAGGATCTAATTTAGTAGATAAACTTATAAATCTAGGACACAATGT
ATGTATAATAGATAATTTATCTACTGGAAATATAAATAATGTAAATAAAAAAGCTCAATTATATATAAATGATATTTTGG
ATCCTAATGTATCAAAAATATTTGAAAAGGAAAAGTTTGATATAGTCTATCATCTAGCAGCGCAGATAGATGTGCAAAAA
TCTATAACGAATCCTATATTTGATTCTAATGTAAATGTATGTGGTACTATAAATATAATAAATAATTGTGTTAACTATAA
TGTTAAAAAAATAGTATATTCTTCTTCAGCAGCTGTCTATGGTTATCCCGGATACTTACCTATAGATGAAAAAAATGGAA
TAATGCCTATATCTTATTACGGATTATCTAAATATACTGCTGAAGAATATATAAGATTATTTAGTAATTTAAATAATTTA
GACTTCACCATACTTAGATATGCAAATGTATATGGAATAAGGCAAGATCCAAAGGGGGAAGGTGGCGTAATATCCATATT
TATGAATAGTTTATTTAAAAAACAACCATTATATATATTTGGAGATGGTAGTGCCTTAAGAGATTACATCTTTGTAGAAG
ATATCGTTGACGCTAATATTGCAGCTCTCAGCAGTGGAAGCAAAGAGAGATTTAATATAGGCACTGGAGTTTATACTTCT
GTCAAGGAACTAGCTGAAAATATGATAGATATCATTGGGCTAAAATGTAATATAGAGTATGAATCAGCTAGAAAAGGAGA
TATAACAAATTCATATTTTAATATTAGTAAAGCTAAAAATAAACTTAACTGGATTCCAAAATTTAGTTTGAAAGATGGAC
TGGAGAAAACTATAGAATATTATAAAAATAATCTAGAAGATTAA

Upstream 100 bases:

>100_bases
TTATTTTCACAACATGATACCTATCATAATATTATGAAAATATGGATTACTACATCCATTAGTTGGTTATTTTAATTTGC
TGTAAAAAGGAGAGAGCTTT

Downstream 100 bases:

>100_bases
AAAGTAAAAAAGAAGAACGCAGCAAGTCTTAGTTGTTTGAGCAAATGGAGCCTGTAAAAAATTTTGTGTAAACTAAATAA
AAGCACTCTTTCTATGCAAT

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKVLVSGGAGFIGSNLVDKLINLGHNVCIIDNLSTGNINNVNKKAQLYINDILDPNVSKIFEKEKFDIVYHLAAQIDVQK
SITNPIFDSNVNVCGTINIINNCVNYNVKKIVYSSSAAVYGYPGYLPIDEKNGIMPISYYGLSKYTAEEYIRLFSNLNNL
DFTILRYANVYGIRQDPKGEGGVISIFMNSLFKKQPLYIFGDGSALRDYIFVEDIVDANIAALSSGSKERFNIGTGVYTS
VKELAENMIDIIGLKCNIEYESARKGDITNSYFNISKAKNKLNWIPKFSLKDGLEKTIEYYKNNLED

Sequences:

>Translated_307_residues
MKVLVSGGAGFIGSNLVDKLINLGHNVCIIDNLSTGNINNVNKKAQLYINDILDPNVSKIFEKEKFDIVYHLAAQIDVQK
SITNPIFDSNVNVCGTINIINNCVNYNVKKIVYSSSAAVYGYPGYLPIDEKNGIMPISYYGLSKYTAEEYIRLFSNLNNL
DFTILRYANVYGIRQDPKGEGGVISIFMNSLFKKQPLYIFGDGSALRDYIFVEDIVDANIAALSSGSKERFNIGTGVYTS
VKELAENMIDIIGLKCNIEYESARKGDITNSYFNISKAKNKLNWIPKFSLKDGLEKTIEYYKNNLED
>Mature_307_residues
MKVLVSGGAGFIGSNLVDKLINLGHNVCIIDNLSTGNINNVNKKAQLYINDILDPNVSKIFEKEKFDIVYHLAAQIDVQK
SITNPIFDSNVNVCGTINIINNCVNYNVKKIVYSSSAAVYGYPGYLPIDEKNGIMPISYYGLSKYTAEEYIRLFSNLNNL
DFTILRYANVYGIRQDPKGEGGVISIFMNSLFKKQPLYIFGDGSALRDYIFVEDIVDANIAALSSGSKERFNIGTGVYTS
VKELAENMIDIIGLKCNIEYESARKGDITNSYFNISKAKNKLNWIPKFSLKDGLEKTIEYYKNNLED

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=315, Percent_Identity=29.2063492063492, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI56237023, Length=338, Percent_Identity=32.5443786982249, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI56118217, Length=338, Percent_Identity=32.5443786982249, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI189083684, Length=338, Percent_Identity=32.5443786982249, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI7657641, Length=323, Percent_Identity=33.7461300309598, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI193211614, Length=350, Percent_Identity=22.2857142857143, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI8393516, Length=350, Percent_Identity=22.2857142857143, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786974, Length=336, Percent_Identity=29.1666666666667, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788353, Length=340, Percent_Identity=29.1176470588235, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI48994969, Length=335, Percent_Identity=27.1641791044776, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790049, Length=288, Percent_Identity=28.4722222222222, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788365, Length=327, Percent_Identity=19.5718654434251, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71982035, Length=329, Percent_Identity=33.434650455927, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982038, Length=331, Percent_Identity=33.2326283987915, Blast_Score=148, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17539532, Length=316, Percent_Identity=28.4810126582279, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17568069, Length=323, Percent_Identity=28.4829721362229, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI115532424, Length=321, Percent_Identity=26.791277258567, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319493, Length=338, Percent_Identity=31.0650887573964, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356223, Length=314, Percent_Identity=30.2547770700637, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI19923002, Length=338, Percent_Identity=31.3609467455621, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34345; Mature: 34345

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVSGGAGFIGSNLVDKLINLGHNVCIIDNLSTGNINNVNKKAQLYINDILDPNVSKI
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHH
FEKEKFDIVYHLAAQIDVQKSITNPIFDSNVNVCGTINIINNCVNYNVKKIVYSSSAAVY
HHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEE
GYPGYLPIDEKNGIMPISYYGLSKYTAEEYIRLFSNLNNLDFTILRYANVYGIRQDPKGE
ECCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHEEECCCCCCC
GGVISIFMNSLFKKQPLYIFGDGSALRDYIFVEDIVDANIAALSSGSKERFNIGTGVYTS
CCEEHEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCCHHHH
VKELAENMIDIIGLKCNIEYESARKGDITNSYFNISKAKNKLNWIPKFSLKDGLEKTIEY
HHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHH
YKNNLED
HHHCCCC
>Mature Secondary Structure
MKVLVSGGAGFIGSNLVDKLINLGHNVCIIDNLSTGNINNVNKKAQLYINDILDPNVSKI
CEEEEECCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCHHHH
FEKEKFDIVYHLAAQIDVQKSITNPIFDSNVNVCGTINIINNCVNYNVKKIVYSSSAAVY
HHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHCCCEEEEEEECCCEEE
GYPGYLPIDEKNGIMPISYYGLSKYTAEEYIRLFSNLNNLDFTILRYANVYGIRQDPKGE
ECCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEHHHEEECCCCCCC
GGVISIFMNSLFKKQPLYIFGDGSALRDYIFVEDIVDANIAALSSGSKERFNIGTGVYTS
CCEEHEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCCCHHHH
VKELAENMIDIIGLKCNIEYESARKGDITNSYFNISKAKNKLNWIPKFSLKDGLEKTIEY
HHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCCCHHHHHHHHHHHH
YKNNLED
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]