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The map label for this gene is tlpC [H]

Identifier: 153936163

GI number: 153936163

Start: 518972

End: 520663

Strand: Direct

Name: tlpC [H]

Synonym: CLC_0512

Alternate gene names: 153936163

Gene position: 518972-520663 (Clockwise)

Preceding gene: 153935206

Following gene: 153936996

Centisome position: 13.8

GC content: 29.08

Gene sequence:

>1692_bases
GTGAGTGGCTTGAAAAATAAGCTTATAAGACAAATAGCTCTTTTGTTTAATGTATTAATACTTATATTATGTGCCACTTT
TTTCATTGGAACTAAATCTATCTTAAAAGGATTAGAAAATAATGATCCCAATTTATTAGCAAGCTTTAGCAGTTCTTACT
TAAAATTTATAGCTATAATGTTTATAATAATGTTAGCAGTTTCTTATATAGTAGTTAGGGTTTTTGTGACTAAAGCATAC
AATTCAATAGAAGAAGTAGCAGAAATAATAGATAGGGTATCTAAAGGTGAATTTGCAACAAGAGTTCCAGAAGAAGGAAT
TTTAGAACCTATTGGAGTAAGTGTAAATGCTATAGTTAGAAATACTAAAAAAATATTATCAGATTTATTACAGATATCAC
AAAAAAATAGGATTATATCAAATACATTACATGAAAATGCACTAGATAGTAACCAAGCTACAGAAAATATAGCATCCTCT
GTGATTTCTGTAGCAGAAACAGCAACAACTCAAGCAGATTCAACTACATCTACAAGAAATAATACAAGTGAAATGGCAGA
AAATTCAACTGTAATAGCAGAAAAAGCTCAAAATACTAAAAATATAGCTGAGGAAATGGTTAAAACAATAAAAGAAAATC
AAAAGACTTTCGAAACTATGATATACAAAATAAAATCTACAGGAGATGTTAGTAAAAAATTAGCTAAGAATGTAAGAATA
TTAGAAAGCGAAGCAGAAGAAATAAGTAAAATAACAGATGTAGTAACAGAAATAAGTGAAAGAACTAATTTGCTTGCATT
AAATGCAGCTATTGAAGCTGCTAGGGCAGGAGAGCATGGGAAAGGATTCTCTGTAGTAGCGGATGAAGTAAGGAAACTTG
CAGAACAATCCTCAGAATCTGCTGGAGAAATAAGAAAATTAATAGAAAAAATTACTTATCAAATAACCAATATAACAGAA
GAAGCAGAAAATCAAAGTAAAGAGGTGGAAGAGGATATAGTTTATGCAGATGAGTCTAGGGAATCATTTAATGAAATAAT
ATCTTCAACAGATGAAACATATAATTCAGTAGAGCAAATATATGATTTATCAGATAAGAATACTACAATATCTAAAGAAG
TAGACCAATTAATGGAAACTATAGCTTCAGGAGCTCAGCAAAGTGCCTCTATGACAGAAGAAATTTCTGCAGCAGTAGAA
GAACAATCTGCATCAATAAATGAGATAACTCAATTAATAAAAGAAATGAATGTATGTACAGATGAGATAGATAGTGAATT
AAAAGCTTTTGTAACCAATATAACTATAAAAGGAGAGCAAAAACAATTAGTCAATGAAGGATTTAATATATTAGAAAAAA
TAAGTAGAGAAATAAATTCTAATAATTTAAGTGTAGATGCCTGTTCTAACATATGCAAACAGTATGTAGAAGCAAATAAT
CAATTTGAATACATTGGTGTAATAGATAAAGAGGGTATAATGAAATCTGCTAATGTACCTATAACAAAAGGAAATGATGA
CTTTTCCCATAGACCTTATTTTAAAAAGGCTATTTTAGGAGAGAAATATGCCAGCAAACCATATATATCTAGTGTTAGTT
ATAACTATTGTATAGCTATAGCTATTTCACTAAAGGATAAAAATGGAAATATTCAAGCTGTAGTAATGGGAGATGTTTGC
ATAGAACAATAG

Upstream 100 bases:

>100_bases
TTTGTAAAAAAATTAACAAATAAGAAGGGAAAAAAATAATATTGTAGAAAATTATATATATTATGTAAAATTAAAATTTT
TATAAATTTAAGGAAGGTTG

Downstream 100 bases:

>100_bases
TATATTGTAGAATATAAGTAAACAATTACAAAAAATATAAATAAAAACCAAAATTTGTTTTAAAGGGGGATCATTAATGA
AAGATGTATTAGAAAGATTC

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSGLKNKLIRQIALLFNVLILILCATFFIGTKSILKGLENNDPNLLASFSSSYLKFIAIMFIIMLAVSYIVVRVFVTKAY
NSIEEVAEIIDRVSKGEFATRVPEEGILEPIGVSVNAIVRNTKKILSDLLQISQKNRIISNTLHENALDSNQATENIASS
VISVAETATTQADSTTSTRNNTSEMAENSTVIAEKAQNTKNIAEEMVKTIKENQKTFETMIYKIKSTGDVSKKLAKNVRI
LESEAEEISKITDVVTEISERTNLLALNAAIEAARAGEHGKGFSVVADEVRKLAEQSSESAGEIRKLIEKITYQITNITE
EAENQSKEVEEDIVYADESRESFNEIISSTDETYNSVEQIYDLSDKNTTISKEVDQLMETIASGAQQSASMTEEISAAVE
EQSASINEITQLIKEMNVCTDEIDSELKAFVTNITIKGEQKQLVNEGFNILEKISREINSNNLSVDACSNICKQYVEANN
QFEYIGVIDKEGIMKSANVPITKGNDDFSHRPYFKKAILGEKYASKPYISSVSYNYCIAIAISLKDKNGNIQAVVMGDVC
IEQ

Sequences:

>Translated_563_residues
MSGLKNKLIRQIALLFNVLILILCATFFIGTKSILKGLENNDPNLLASFSSSYLKFIAIMFIIMLAVSYIVVRVFVTKAY
NSIEEVAEIIDRVSKGEFATRVPEEGILEPIGVSVNAIVRNTKKILSDLLQISQKNRIISNTLHENALDSNQATENIASS
VISVAETATTQADSTTSTRNNTSEMAENSTVIAEKAQNTKNIAEEMVKTIKENQKTFETMIYKIKSTGDVSKKLAKNVRI
LESEAEEISKITDVVTEISERTNLLALNAAIEAARAGEHGKGFSVVADEVRKLAEQSSESAGEIRKLIEKITYQITNITE
EAENQSKEVEEDIVYADESRESFNEIISSTDETYNSVEQIYDLSDKNTTISKEVDQLMETIASGAQQSASMTEEISAAVE
EQSASINEITQLIKEMNVCTDEIDSELKAFVTNITIKGEQKQLVNEGFNILEKISREINSNNLSVDACSNICKQYVEANN
QFEYIGVIDKEGIMKSANVPITKGNDDFSHRPYFKKAILGEKYASKPYISSVSYNYCIAIAISLKDKNGNIQAVVMGDVC
IEQ
>Mature_562_residues
SGLKNKLIRQIALLFNVLILILCATFFIGTKSILKGLENNDPNLLASFSSSYLKFIAIMFIIMLAVSYIVVRVFVTKAYN
SIEEVAEIIDRVSKGEFATRVPEEGILEPIGVSVNAIVRNTKKILSDLLQISQKNRIISNTLHENALDSNQATENIASSV
ISVAETATTQADSTTSTRNNTSEMAENSTVIAEKAQNTKNIAEEMVKTIKENQKTFETMIYKIKSTGDVSKKLAKNVRIL
ESEAEEISKITDVVTEISERTNLLALNAAIEAARAGEHGKGFSVVADEVRKLAEQSSESAGEIRKLIEKITYQITNITEE
AENQSKEVEEDIVYADESRESFNEIISSTDETYNSVEQIYDLSDKNTTISKEVDQLMETIASGAQQSASMTEEISAAVEE
QSASINEITQLIKEMNVCTDEIDSELKAFVTNITIKGEQKQLVNEGFNILEKISREINSNNLSVDACSNICKQYVEANNQ
FEYIGVIDKEGIMKSANVPITKGNDDFSHRPYFKKAILGEKYASKPYISSVSYNYCIAIAISLKDKNGNIQAVVMGDVCI
EQ

Specific function: Mediates Taxis To The Sugars Ribose And Galactose VIa An Interaction With The Periplasmic Ribose- Or Galactose-Binding Proteins. Chemotactic-Signal Transducers Respond To Changes In The Concentration Of Attractants And Repellents In The Environment, Trans

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=360, Percent_Identity=27.2222222222222, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI2367378, Length=322, Percent_Identity=26.7080745341615, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1789453, Length=239, Percent_Identity=28.8702928870293, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788194, Length=366, Percent_Identity=25.1366120218579, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788195, Length=256, Percent_Identity=29.6875, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 62259; Mature: 62128

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2 ; PS50192 T_SNARE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGLKNKLIRQIALLFNVLILILCATFFIGTKSILKGLENNDPNLLASFSSSYLKFIAIM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FIIMLAVSYIVVRVFVTKAYNSIEEVAEIIDRVSKGEFATRVPEEGILEPIGVSVNAIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHH
NTKKILSDLLQISQKNRIISNTLHENALDSNQATENIASSVISVAETATTQADSTTSTRN
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NTSEMAENSTVIAEKAQNTKNIAEEMVKTIKENQKTFETMIYKIKSTGDVSKKLAKNVRI
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LESEAEEISKITDVVTEISERTNLLALNAAIEAARAGEHGKGFSVVADEVRKLAEQSSES
HHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
AGEIRKLIEKITYQITNITEEAENQSKEVEEDIVYADESRESFNEIISSTDETYNSVEQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
YDLSDKNTTISKEVDQLMETIASGAQQSASMTEEISAAVEEQSASINEITQLIKEMNVCT
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DEIDSELKAFVTNITIKGEQKQLVNEGFNILEKISREINSNNLSVDACSNICKQYVEANN
HHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
QFEYIGVIDKEGIMKSANVPITKGNDDFSHRPYFKKAILGEKYASKPYISSVSYNYCIAI
CEEEEEEECCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCEEEEE
AISLKDKNGNIQAVVMGDVCIEQ
EEEEECCCCCEEEEEECCHHHCC
>Mature Secondary Structure 
SGLKNKLIRQIALLFNVLILILCATFFIGTKSILKGLENNDPNLLASFSSSYLKFIAIM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
FIIMLAVSYIVVRVFVTKAYNSIEEVAEIIDRVSKGEFATRVPEEGILEPIGVSVNAIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCHHHHHHH
NTKKILSDLLQISQKNRIISNTLHENALDSNQATENIASSVISVAETATTQADSTTSTRN
HHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
NTSEMAENSTVIAEKAQNTKNIAEEMVKTIKENQKTFETMIYKIKSTGDVSKKLAKNVRI
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LESEAEEISKITDVVTEISERTNLLALNAAIEAARAGEHGKGFSVVADEVRKLAEQSSES
HHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
AGEIRKLIEKITYQITNITEEAENQSKEVEEDIVYADESRESFNEIISSTDETYNSVEQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
YDLSDKNTTISKEVDQLMETIASGAQQSASMTEEISAAVEEQSASINEITQLIKEMNVCT
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DEIDSELKAFVTNITIKGEQKQLVNEGFNILEKISREINSNNLSVDACSNICKQYVEANN
HHHHHHHHHHHHHCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
QFEYIGVIDKEGIMKSANVPITKGNDDFSHRPYFKKAILGEKYASKPYISSVSYNYCIAI
CEEEEEEECCCCCHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCEEEEE
AISLKDKNGNIQAVVMGDVCIEQ
EEEEECCCCCEEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7921238; 7704255; 8969502; 9384377 [H]