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The map label for this gene is strD [H]

Identifier: 153935912

GI number: 153935912

Start: 2124316

End: 2125377

Strand: Direct

Name: strD [H]

Synonym: CLC_1999

Alternate gene names: 153935912

Gene position: 2124316-2125377 (Clockwise)

Preceding gene: 153936349

Following gene: 153935869

Centisome position: 56.49

GC content: 35.31

Gene sequence:

>1062_bases
ATGAAAGCGTTAATTTTAAGTGGTGGTACAGGTACAAGACTAAGGCCATTAACCTATACCAATGCAAAACAATTGTTGCC
TTTGGCGAATAAACCAATATTGTTTTATATCATTGAAAAGATTGTAAAAGCAGGAATATACGATATTGGCATTATTGTTG
GTGATACTCGTGAAGAGGTAAAAAAGATGGTGGGAAACGGAGACCGATGGGGTGTAAAAATTAGTTATTTATATCAACCT
ATGCCATTAGGCCTTGCCCATGCAGTTAAAACGGCATCAGAATTCTTAATGGAAGATGATTTTTTAATGGTGCTGGGAGA
TAACGTATTTAATATGGAACTGAATAAATTGATTGATAGCTTTTATTCAAATAATGCAAACTCAGCTTTATTGCTTCACA
AAGTTGAAAATCCTTCACAATATGGGGTTGCCGTAGTAGAAGACACCCTTATCATAAAGCTCGTTGAAAAGCCGAAGGAA
TTCGTTAGTGATTTGATAATAACAGGAGTATATATTTTTGATAAGAGCATTTTTATGGCTATCGATAATATTAAACCATC
CCAAAGAGGAGAGTTGGAAATAACCGATGCTATTCAAAAGCAGTTGGAAACAGGGGGAAGAGTCACATATGAGCTTATTC
AAGGCTGGTGGAAAGACACTGGGCAACTGCAGGATATTTTGGAGGCCAATAGGTTAATGCTTGATGAGATTGATTGTGAG
TTCAAGACTTTACCTCAATCTAATTCTGTATTTATGGGAAAAATCCAAATCGGGAAAAATGTTATTATCGAAAACAGTAC
AATTATAGGGCCTGTTGCCATAGCAGATGATACAACTATTACAAATAGTTGTATAGGGCCTTATACCTCTATAGATAAAG
CGGTTACGGTTAATGACTGTGAGATTGATAATTGTATTATTCTTGAAAATGCCAAAATTGATGGCATACACAAAAGAATC
AGCGGCAGTCTCATTGGAAGAAAAGTTCAAATCAAAGAACTTCATAAGAGACCGTTTTCTCATACTTTCCTTTTAGGTGA
TGATAGTGAAATTGATCTTTAG

Upstream 100 bases:

>100_bases
TTTAATAGAAACTATTTTTATGCACCATTATGATACTCGAGAATATTATGTAAATATAAGAAATACATTAAAGCGCCAGA
AGGTATAAAGGAGGTATAAC

Downstream 100 bases:

>100_bases
AGAAAATTAAATATAAATTCATGATTGGAGGAAGTTTTTAAATGAGAGTTTTACTTGTAACAGGTGGTGCAGGCTTTATT
GGCAGCAATTTTATACGATA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
MPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDEIDCE
FKTLPQSNSVFMGKIQIGKNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL

Sequences:

>Translated_353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
MPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDEIDCE
FKTLPQSNSVFMGKIQIGKNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
>Mature_353_residues
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEVKKMVGNGDRWGVKISYLYQP
MPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDSFYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKE
FVSDLIITGVYIFDKSIFMAIDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDEIDCE
FKTLPQSNSVFMGKIQIGKNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDCEIDNCIILENAKIDGIHKRI
SGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=355, Percent_Identity=31.2676056338028, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI11761619, Length=340, Percent_Identity=31.7647058823529, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI31881779, Length=368, Percent_Identity=24.4565217391304, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI45447090, Length=368, Percent_Identity=24.4565217391304, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=38.135593220339, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=35.0210970464135, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788355, Length=270, Percent_Identity=25.1851851851852, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=337, Percent_Identity=31.7507418397626, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17509979, Length=332, Percent_Identity=25.6024096385542, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17509981, Length=319, Percent_Identity=24.7648902821317, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=359, Percent_Identity=30.6406685236769, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21355443, Length=346, Percent_Identity=30.635838150289, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24644084, Length=346, Percent_Identity=30.635838150289, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI24653912, Length=369, Percent_Identity=24.9322493224932, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39354; Mature: 39354

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEV
CCEEEEECCCCCEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHH
KKMVGNGDRWGVKISYLYQPMPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDS
HHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHH
FYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKEFVSDLIITGVYIFDKSIFMA
HHCCCCCCEEEEEECCCCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHEECCEEEEE
IDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDEIDCE
EECCCCCCCCCEEHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHEEHHCCCC
FKTLPQSNSVFMGKIQIGKNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDC
EEECCCCCCEEEEEEEECCEEEEECCEEEEEEEECCCCEECCCCCCCCCCCCCEEEECCC
EIDNCIILENAKIDGIHKRISGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
CCCCEEEEECCCCCHHHHHHHHHHHCCEEHHHHHHCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKALILSGGTGTRLRPLTYTNAKQLLPLANKPILFYIIEKIVKAGIYDIGIIVGDTREEV
CCEEEEECCCCCEEEEEEECCHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHH
KKMVGNGDRWGVKISYLYQPMPLGLAHAVKTASEFLMEDDFLMVLGDNVFNMELNKLIDS
HHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEHHHHHHHHH
FYSNNANSALLLHKVENPSQYGVAVVEDTLIIKLVEKPKEFVSDLIITGVYIFDKSIFMA
HHCCCCCCEEEEEECCCCCCCCEEEEECCEEEHHHHHHHHHHHHHHHHHHHEECCEEEEE
IDNIKPSQRGELEITDAIQKQLETGGRVTYELIQGWWKDTGQLQDILEANRLMLDEIDCE
EECCCCCCCCCEEHHHHHHHHHHCCCCEEHHHHHHHHCCCHHHHHHHHHHHHEEHHCCCC
FKTLPQSNSVFMGKIQIGKNVIIENSTIIGPVAIADDTTITNSCIGPYTSIDKAVTVNDC
EEECCCCCCEEEEEEEECCEEEEECCEEEEEEEECCCCEECCCCCCCCCCCCCEEEECCC
EIDNCIILENAKIDGIHKRISGSLIGRKVQIKELHKRPFSHTFLLGDDSEIDL
CCCCEEEEECCCCCHHHHHHHHHHHCCEEHHHHHHCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]