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The map label for this gene is vanR [H]

Identifier: 153935657

GI number: 153935657

Start: 682332

End: 683024

Strand: Direct

Name: vanR [H]

Synonym: CLC_0665

Alternate gene names: 153935657

Gene position: 682332-683024 (Clockwise)

Preceding gene: 153934731

Following gene: 153934812

Centisome position: 18.14

GC content: 29.15

Gene sequence:

>693_bases
ATGAATAATAATATTCTTGTGGTAGATGATGAAAAAGAAATAAGAGATTTATTAGAAATAAATCTTATAAATGAGGGGTA
TAATGTGTTTAAGGCAAGTTGCGGAGAAGAAGCCTTAGAAATATTAGAAAGAGAAGAAGTTAATTTAATGGTTTTAGATA
TAATGATGCCAGATATGGATGGTTTAGAAGTTTGCAAAAGAGCACGGGAAAAGTATAGCATACCAATTCTTATGCTAAGT
GCAAAAGTAGAGGATATGGATAGGATAGAAGGTATCATGACTGGTGCAGATGATTATGTATGTAAGCCTTTTAATCATTT
AGAACTTACAGTTAGGATAAGAGCATTACTTAGAAGAGCATATTTTTTAAATACTAAAATGCAAATCTCAGATAACATAA
TAAGAATTGAGTCAATGGTTATAGATAAGAAGCAACATAAGGTAACAATAAATGATAATGAAATAGATTTAACAGCAAGA
GAATTTGAAATTTTATATTTATTAGCTAACAATAGGGGAATGGTTTTTAGTGCAGAGGAAATTTTTGAAAAGGTTTGGAA
AGAAAGATATTTTCAATCTAATAATACTGTTATGGTACATATGAGTAGACTTAGAGATAAAATAGAACAACATATGGAAG
GTAGTAAGGTAATCCATACTGTGTGGGGAGTTGGTTACAAAATTGAAAAATAA

Upstream 100 bases:

>100_bases
ATATTAGATATGTTGGGAAAGAAGCTGCTAAATATATTTATGATAACAAAATTACCTTAGAGGAATACTTAGGTAAATAA
TCATATAATTGGAGGAAAAT

Downstream 100 bases:

>100_bases
AAGATTATATAAATATTGTTTATCGTCGTTGAGAGACATATTAATAGCTTTAATATTAACTTACACAACAGCGTATATAA
GTAAGAAAATATTAAACTAT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNNNILVVDDEKEIRDLLEINLINEGYNVFKASCGEEALEILEREEVNLMVLDIMMPDMDGLEVCKRAREKYSIPILMLS
AKVEDMDRIEGIMTGADDYVCKPFNHLELTVRIRALLRRAYFLNTKMQISDNIIRIESMVIDKKQHKVTINDNEIDLTAR
EFEILYLLANNRGMVFSAEEIFEKVWKERYFQSNNTVMVHMSRLRDKIEQHMEGSKVIHTVWGVGYKIEK

Sequences:

>Translated_230_residues
MNNNILVVDDEKEIRDLLEINLINEGYNVFKASCGEEALEILEREEVNLMVLDIMMPDMDGLEVCKRAREKYSIPILMLS
AKVEDMDRIEGIMTGADDYVCKPFNHLELTVRIRALLRRAYFLNTKMQISDNIIRIESMVIDKKQHKVTINDNEIDLTAR
EFEILYLLANNRGMVFSAEEIFEKVWKERYFQSNNTVMVHMSRLRDKIEQHMEGSKVIHTVWGVGYKIEK
>Mature_230_residues
MNNNILVVDDEKEIRDLLEINLINEGYNVFKASCGEEALEILEREEVNLMVLDIMMPDMDGLEVCKRAREKYSIPILMLS
AKVEDMDRIEGIMTGADDYVCKPFNHLELTVRIRALLRRAYFLNTKMQISDNIIRIESMVIDKKQHKVTINDNEIDLTAR
EFEILYLLANNRGMVFSAEEIFEKVWKERYFQSNNTVMVHMSRLRDKIEQHMEGSKVIHTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.0044052863436, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=35.6828193832599, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=30.9734513274336, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=32.4561403508772, Blast_Score=136, Evalue=9e-34,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=32.2869955156951, Blast_Score=133, Evalue=8e-33,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=32.034632034632, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=34.2105263157895, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=31.4159292035398, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=34.2222222222222, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=34.070796460177, Blast_Score=120, Evalue=5e-29,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.7359307359307, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=34.0807174887892, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=31.5315315315315, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=29.1304347826087, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788550, Length=117, Percent_Identity=32.4786324786325, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=35.3982300884956, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26981; Mature: 26981

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
6.1 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNILVVDDEKEIRDLLEINLINEGYNVFKASCGEEALEILEREEVNLMVLDIMMPDMD
CCCCEEEEECHHHHHHHHHHEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCC
GLEVCKRAREKYSIPILMLSAKVEDMDRIEGIMTGADDYVCKPFNHLELTVRIRALLRRA
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHH
YFLNTKMQISDNIIRIESMVIDKKQHKVTINDNEIDLTAREFEILYLLANNRGMVFSAEE
HHHCCEEEECCCEEEEHHHHCCCCCCEEEECCCEEEEEEEEEEEEEEEECCCCEEEEHHH
IFEKVWKERYFQSNNTVMVHMSRLRDKIEQHMEGSKVIHTVWGVGYKIEK
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEHHHHCCCEEECC
>Mature Secondary Structure
MNNNILVVDDEKEIRDLLEINLINEGYNVFKASCGEEALEILEREEVNLMVLDIMMPDMD
CCCCEEEEECHHHHHHHHHHEEECCCCHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCC
GLEVCKRAREKYSIPILMLSAKVEDMDRIEGIMTGADDYVCKPFNHLELTVRIRALLRRA
HHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHCCCCCCEECCCCCEEHHHHHHHHHHHH
YFLNTKMQISDNIIRIESMVIDKKQHKVTINDNEIDLTAREFEILYLLANNRGMVFSAEE
HHHCCEEEECCCEEEEHHHHCCCCCCEEEECCCEEEEEEEEEEEEEEEECCCCEEEEHHH
IFEKVWKERYFQSNNTVMVHMSRLRDKIEQHMEGSKVIHTVWGVGYKIEK
HHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCEEHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]