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The map label for this gene is panF [H]

Identifier: 153935356

GI number: 153935356

Start: 419442

End: 420857

Strand: Direct

Name: panF [H]

Synonym: CLC_0425

Alternate gene names: 153935356

Gene position: 419442-420857 (Clockwise)

Preceding gene: 153934845

Following gene: 153936091

Centisome position: 11.15

GC content: 30.16

Gene sequence:

>1416_bases
GTGAAGGGATATTTAATATTTATAATAATATATGCCATAATACTTATATTAGCAGGATTTTTTGTAAAAAAATATGTAAA
AAGTGCTGCAGATTTTTTTGTGGCAGGAAGAAAACTTAACTCTAAATTATTATGTACTACTTTAATAGCAGCAAATATAG
GGGCAGGGTCCACTGTAGGCATAACGGGGATTGCATATAAGTATGGAGTATCTTCTTATTGGTGGATATTTATGTCTGCT
ATAGGAACAGCTGTACTAGCTTTTTTGGTAGGGCCTAAAATATGGGAAAAATCTATGAAATACAATTTGTATACCTTAGG
AGATTATTTGGATATAAGATATTCTAAATATTTCAAAGGAGCTATATCTATAATGATGACCATAGGTACATTAGCATTAT
TTGCAGGTCAACTTATGGGAATTGCATGGATATTAGATGTAACTTCAGGTATTGATAAAAATATAGGAATTTTAATTGGG
GCAGTAGTTGTGGTTCTTTATTTTTCATCCGGTGGGCTTTTGTCCTCAGCTATAGTAAACGTATTGGAATTAGTAATAAT
AATACTAGGTTTTATAATTGCAGTACCATTTTGTATAAAAAGCGTAAATGGATTTAGTGGATTACATACAGCCATATTAA
ATAATTTACCAGCAAATGAAGGTGTAAATTATTTTAGTTTAAAAGGTATAGGTATAAGTACTATAGTAGGATGGTTTTTA
ATGCTTACACCATCATTTTTTATATCACCAGGATTAATAGGGAAAGTTTATGGAGCAAAAGATATGAAAACTATAAAAAA
GGGAGCAGGAATATGTGCAGTAGTTCAAGGATTATTTGCATTTTTGCCCACTATATTAGGAATGTGTGCCTTTGCAGTGT
TCCCTAATCTTAATCAACAGGAATTAGCATTACCTATGGTTATGAAAAACCTAATGCCTTTTTCAGTATCGGCTTTAGCA
TTAGCGGCTATATTTGCAGCGGAGGTTAGTACAGCAGATGCAGTTTTGTATATGTTAACAACCACCTTTACAGAAGATAT
ATATAAAACTTTTATAAATCCCAAAATAGAAGATAAAAAGTTATTAAAAGCAGGGAGAATAGTTACAATTGTAGGAGGAA
TATTAGGAGTAGCTATGGCTTTTATATTACCTAATATAATAACAGCATTGTCTATATTTTATACACTAATGTCAGTTTCT
TTAACAGTACCACTATTATTTGGACTATTTTCAGAAAAACCAAATACGAAAATTGCTTTTACATCATCCATAATAGGAAT
AATAATAACATTATATTTACAATTTCAAAACAATGATAAAGGTATATGGATATTAAATGCACAATCTACAGGCATATTAT
GTTCTTTGATTGCAATGATAATCTTTCTAGCCCTAAAAAAGAAAACTACTACTTAA

Upstream 100 bases:

>100_bases
TAAAACCTGGTGCAATTGCATCAGGTTTTAAGTTATAATATAATGAAAAATATTATATATAAAATATTTATTAAACAAAC
ATATTTAAGAGGAGGGCATT

Downstream 100 bases:

>100_bases
CAGGTTTTAAAGATTGAGAATTAAAACAAGAAATACTTTTGTTCAATATATAGCTATAAAAATATTTCTTGTTTTAATGC
CTTTAAAGGCTGTTATAATA

Product: sodium:solute symporter family protein

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKSAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFLVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGIDKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIAMIIFLALKKKTTT

Sequences:

>Translated_471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKSAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFLVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGIDKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIAMIIFLALKKKTTT
>Mature_471_residues
MKGYLIFIIIYAIILILAGFFVKKYVKSAADFFVAGRKLNSKLLCTTLIAANIGAGSTVGITGIAYKYGVSSYWWIFMSA
IGTAVLAFLVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKGAISIMMTIGTLALFAGQLMGIAWILDVTSGIDKNIGILIG
AVVVVLYFSSGGLLSSAIVNVLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQELALPMVMKNLMPFSVSALA
LAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKKLLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVS
LTVPLLFGLFSEKPNTKIAFTSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIAMIIFLALKKKTTT

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI14140236, Length=402, Percent_Identity=23.3830845771144, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI11141885, Length=487, Percent_Identity=23.8193018480493, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI87082237, Length=423, Percent_Identity=25.7683215130024, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790113, Length=366, Percent_Identity=23.7704918032787, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787251, Length=388, Percent_Identity=22.680412371134, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24648033, Length=452, Percent_Identity=22.787610619469, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356865, Length=452, Percent_Identity=22.787610619469, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 50838; Mature: 50838

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGYLIFIIIYAIILILAGFFVKKYVKSAADFFVAGRKLNSKLLCTTLIAANIGAGSTVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
ITGIAYKYGVSSYWWIFMSAIGTAVLAFLVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AISIMMTIGTLALFAGQLMGIAWILDVTSGIDKNIGILIGAVVVVLYFSSGGLLSSAIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
VLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQ
HHCHHHHCCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELALPMVMKNLMPFSVSALALAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVSLTVPLLFGLFSEKPNTKIAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIAMIIFLALKKKTTT
HHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKGYLIFIIIYAIILILAGFFVKKYVKSAADFFVAGRKLNSKLLCTTLIAANIGAGSTVG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCC
ITGIAYKYGVSSYWWIFMSAIGTAVLAFLVGPKIWEKSMKYNLYTLGDYLDIRYSKYFKG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCEEEECCHHHHHHHHHHHH
AISIMMTIGTLALFAGQLMGIAWILDVTSGIDKNIGILIGAVVVVLYFSSGGLLSSAIVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHH
VLELVIIILGFIIAVPFCIKSVNGFSGLHTAILNNLPANEGVNYFSLKGIGISTIVGWFL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHH
MLTPSFFISPGLIGKVYGAKDMKTIKKGAGICAVVQGLFAFLPTILGMCAFAVFPNLNQQ
HHCHHHHCCCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ELALPMVMKNLMPFSVSALALAAIFAAEVSTADAVLYMLTTTFTEDIYKTFINPKIEDKK
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
LLKAGRIVTIVGGILGVAMAFILPNIITALSIFYTLMSVSLTVPLLFGLFSEKPNTKIAF
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
TSSIIGIIITLYLQFQNNDKGIWILNAQSTGILCSLIAMIIFLALKKKTTT
HHHHHHHHHHHHEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]