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The map label for this gene is vanR [H]

Identifier: 153935185

GI number: 153935185

Start: 304324

End: 305001

Strand: Direct

Name: vanR [H]

Synonym: CLC_0323

Alternate gene names: 153935185

Gene position: 304324-305001 (Clockwise)

Preceding gene: 153935768

Following gene: 153935782

Centisome position: 8.09

GC content: 27.43

Gene sequence:

>678_bases
ATGAAGGAAACTATACTTGTTATAGATGATGAAGTTAAGATAATAGAAGTTATAAAATTGTATTTAGAAAATGAGGGATA
TACTGTTATACAGGCTACAAGTGGGATTGAGGCATTAGAAAAGCAAAGTGAGTTTAATCCTGATCTATTAATATTAGATT
TAATGCTACCTGATATATCAGGTGAAAATGTCTGTGAGCGCATAAGGAGAGAATCTGAAGTACCAATAATTATGCTAACT
GCTAAATCAAGTGAAGATAGTATACTAAATGGATATTCAATTGGAAGTGATGACTATATAACAAAACCATTTAGTCCAAA
GCAATTAGTAGCAAAGGTTAATGCAGTTTTGAAAAGAGTTAAGGGAAATCAACGCGAAAACTTAATTTTTAATAATGAAT
TAATCATAGATATTGTTAATAAGAAAGTAGAATACAATAACAAAGAAATTATATTAACTGCTTCGGAATATAAAATACTA
TCTATACTAGCTAAAAATCCTAATAAAATATTTTCAAGGGAAGAGTTAATGGATTATATAAGTAGAGATAATACTTGTAT
CTATGATAGAATAATTGATACTCATATAAAAAATATAAGAGCCAAATTAGATCAAGATAGTAAAAATCCAACCTATATAA
AGACTATTCGTGGTATGGGATATAGGTTCAATGTTTAA

Upstream 100 bases:

>100_bases
AAATTTAGTGTATGATCATGTAGGAATCATTAATAAAGAAATACTTGATGAAAATATAAATAAGATAATTAATTAAGTAC
CTATATGGAGGTATAATTTT

Downstream 100 bases:

>100_bases
TAAATTAAGATATAGAGTAAGCTTGATTTTTATATTATTTTCATTGAGTATCATATTTTTAGCAAACATAGTAAACCATT
ATTGTATCGAAAAGAAGTTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDISGENVCERIRRESEVPIIMLT
AKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRVKGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKIL
SILAKNPNKIFSREELMDYISRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV

Sequences:

>Translated_225_residues
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDISGENVCERIRRESEVPIIMLT
AKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRVKGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKIL
SILAKNPNKIFSREELMDYISRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV
>Mature_225_residues
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDISGENVCERIRRESEVPIIMLT
AKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRVKGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKIL
SILAKNPNKIFSREELMDYISRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=39.4618834080717, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=35.2422907488987, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=36.036036036036, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=33.3333333333333, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=29.5454545454545, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.0396475770925, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=32.8947368421053, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=30.1801801801802, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=33.0357142857143, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=30.2752293577982, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.0810810810811, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=26.605504587156, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=30.2631578947368, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=29.8701298701299, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790299, Length=138, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=30, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25865; Mature: 25865

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDIS
CCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCC
GENVCERIRRESEVPIIMLTAKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRV
CHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
KGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKILSILAKNPNKIFSREELMDYI
CCCCCCCEEECCEEEEEEECCEEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHH
SRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV
CCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECC
>Mature Secondary Structure
MKETILVIDDEVKIIEVIKLYLENEGYTVIQATSGIEALEKQSEFNPDLLILDLMLPDIS
CCCEEEEEECCHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCEEEEEEECCCCC
GENVCERIRRESEVPIIMLTAKSSEDSILNGYSIGSDDYITKPFSPKQLVAKVNAVLKRV
CHHHHHHHHHCCCCCEEEEEECCCCCCEECCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
KGNQRENLIFNNELIIDIVNKKVEYNNKEIILTASEYKILSILAKNPNKIFSREELMDYI
CCCCCCCEEECCEEEEEEECCEEECCCCEEEEEECCCEEEEEEECCCHHHHHHHHHHHHH
SRDNTCIYDRIIDTHIKNIRAKLDQDSKNPTYIKTIRGMGYRFNV
CCCCCEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]