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The map label for this gene is asnC

Identifier: 153935177

GI number: 153935177

Start: 669052

End: 670443

Strand: Direct

Name: asnC

Synonym: CLC_0651

Alternate gene names: 153935177

Gene position: 669052-670443 (Clockwise)

Preceding gene: 153934999

Following gene: 153937059

Centisome position: 17.79

GC content: 31.68

Gene sequence:

>1392_bases
ATGGATATAACTTTAGTAAAATCACTTTATAGAGAAACAGAAAAACACATGGACAAAGAAGTTAAAATTAATGGATGGGT
AAGAACTGTAAGAGATTCTAAAAACTTTGCCTTTGTAGAAGTAAATGACGGAAGTTTCTTTAAAAATGTTCAAGTAATAC
TTGAGTCTTCTTTAGAAAACTTTAAAGAACTATGCAAAATGCCAATAAGTACATCAGTAGAAGTAGAAGGAATAGTTCAA
CCTACACCAAATGCAAAGCAACCTTTCGAAATAAAGGCTACAAGAATTTCAATAGAAGGTAAATCAAGCACAGATTATCC
CTTACAAAAGAAAAGACATACTTTTGAATATTTAAGAACTATAGCTCATTTAAGACCAAGAAGCAATGCTTTTTCAGCAG
TATTTAGAGTACGTTCTTTAGCAGCTTATGCAGTGCATAAATTTTTCCAAGAAAGAGGATTTGTTTATACAAACACCCCA
ATAATAACAGGTAGTGACTGCGAAGGGGCAGGAGAAATGTTCCAATTAACTACTATGGATTTAAACAATATACCAAAAAC
TGAAGAAGGAAAAATAGATTTTTCAAAGGATTTCTTTGGATCACCTGCAAACCTTACAGTAAGTGGTCAGCTTTCAGCAG
AAACTTTTGCTTTAGCTTTTAGAAACGTATATACTTTTGGACCAACTTTTAGAGCTGAAAATTCAAACACTGCAAGACAC
GCATCAGAATTTTGGATGATAGAACCTGAAATGGCATTTGCAGAACTTACAGATTATTTAGATAATGCAGAGGATATGGT
TAAATTTGTAATAAACTATGTAATGGAAAATGCTCCAGAAGAAATGGCATTTTTCAATAGTTTCGTAGATAAAGGTTTAT
TTGATAGATTAGATAATGTTGTGAATTCTGACTTCAAGAGAATAACTTATACAGAAGCAGTAGAATTACTTCAAAAATCA
GGAGTAAAATTTGATTATGAAGTAGAATGGGGAATAGACCTTCAAACTGAACATGAAAGATATTTAACAGAACAAATATT
TAAAAAACCAGTATTTGTAACAGATTATCCAAAGGACATAAAAGCCTTCTATATGAGATTAAATGATGATGGAAAAACTG
TTGCAGCAGCAGACTTACTTGTACCAGGAGTAGGAGAAATTATAGGTGGAAGCCAAAGGGAAGAAAGATTAGATGTATTA
GAAAAAAGAATGGAAGAATTAAATCTAAATAAAGAAGATTACTGGTGGTATTTAGAATTAAGAAAATATGGAGAAACTAA
ACACTCAGGATATGGTTTAGGTTTTGAAAGAATATTAATGTACATCACAGGAATGACTAATATAAGAGACGTAATACCAT
TCCCAAGAACTCCAGGCTCAGCTGAATTCTAA

Upstream 100 bases:

>100_bases
GGCAATTTGGGTGGTACCGCGGAATATATACCTTTCGTCCCTGTAGGGATGAGAGGTTTTTTTATTATTATGAAATAAAA
TCCAAAGAGGAGGAAAAAAC

Downstream 100 bases:

>100_bases
AATAAAAAATATTTAAGTTGATTATATAATTTAAAAAGATAAATTTATAAAAAGTAGCACAATTTTATTTGGTGCTACTT
TTTATATTTTTATCAATAGA

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDITLVKSLYRETEKHMDKEVKINGWVRTVRDSKNFAFVEVNDGSFFKNVQVILESSLENFKELCKMPISTSVEVEGIVQ
PTPNAKQPFEIKATRISIEGKSSTDYPLQKKRHTFEYLRTIAHLRPRSNAFSAVFRVRSLAAYAVHKFFQERGFVYTNTP
IITGSDCEGAGEMFQLTTMDLNNIPKTEEGKIDFSKDFFGSPANLTVSGQLSAETFALAFRNVYTFGPTFRAENSNTARH
ASEFWMIEPEMAFAELTDYLDNAEDMVKFVINYVMENAPEEMAFFNSFVDKGLFDRLDNVVNSDFKRITYTEAVELLQKS
GVKFDYEVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDIKAFYMRLNDDGKTVAAADLLVPGVGEIIGGSQREERLDVL
EKRMEELNLNKEDYWWYLELRKYGETKHSGYGLGFERILMYITGMTNIRDVIPFPRTPGSAEF

Sequences:

>Translated_463_residues
MDITLVKSLYRETEKHMDKEVKINGWVRTVRDSKNFAFVEVNDGSFFKNVQVILESSLENFKELCKMPISTSVEVEGIVQ
PTPNAKQPFEIKATRISIEGKSSTDYPLQKKRHTFEYLRTIAHLRPRSNAFSAVFRVRSLAAYAVHKFFQERGFVYTNTP
IITGSDCEGAGEMFQLTTMDLNNIPKTEEGKIDFSKDFFGSPANLTVSGQLSAETFALAFRNVYTFGPTFRAENSNTARH
ASEFWMIEPEMAFAELTDYLDNAEDMVKFVINYVMENAPEEMAFFNSFVDKGLFDRLDNVVNSDFKRITYTEAVELLQKS
GVKFDYEVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDIKAFYMRLNDDGKTVAAADLLVPGVGEIIGGSQREERLDVL
EKRMEELNLNKEDYWWYLELRKYGETKHSGYGLGFERILMYITGMTNIRDVIPFPRTPGSAEF
>Mature_463_residues
MDITLVKSLYRETEKHMDKEVKINGWVRTVRDSKNFAFVEVNDGSFFKNVQVILESSLENFKELCKMPISTSVEVEGIVQ
PTPNAKQPFEIKATRISIEGKSSTDYPLQKKRHTFEYLRTIAHLRPRSNAFSAVFRVRSLAAYAVHKFFQERGFVYTNTP
IITGSDCEGAGEMFQLTTMDLNNIPKTEEGKIDFSKDFFGSPANLTVSGQLSAETFALAFRNVYTFGPTFRAENSNTARH
ASEFWMIEPEMAFAELTDYLDNAEDMVKFVINYVMENAPEEMAFFNSFVDKGLFDRLDNVVNSDFKRITYTEAVELLQKS
GVKFDYEVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDIKAFYMRLNDDGKTVAAADLLVPGVGEIIGGSQREERLDVL
EKRMEELNLNKEDYWWYLELRKYGETKHSGYGLGFERILMYITGMTNIRDVIPFPRTPGSAEF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=446, Percent_Identity=45.9641255605381, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI4758762, Length=453, Percent_Identity=28.9183222958057, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI45439306, Length=490, Percent_Identity=25.5102040816327, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1787161, Length=451, Percent_Identity=56.3192904656319, Blast_Score=542, Evalue=1e-155,
Organism=Escherichia coli, GI1790571, Length=368, Percent_Identity=24.4565217391304, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788173, Length=109, Percent_Identity=33.9449541284404, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71984122, Length=460, Percent_Identity=31.9565217391304, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17556372, Length=426, Percent_Identity=31.4553990610329, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17551876, Length=477, Percent_Identity=24.9475890985325, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6319872, Length=490, Percent_Identity=39.7959183673469, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6321807, Length=472, Percent_Identity=27.9661016949153, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6323011, Length=343, Percent_Identity=29.1545189504373, Blast_Score=123, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19922416, Length=450, Percent_Identity=36, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI19921528, Length=462, Percent_Identity=29.004329004329, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI17136276, Length=354, Percent_Identity=26.271186440678, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_CLOB1 (A7FRK8)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001382985.1
- ProteinModelPortal:   A7FRK8
- SMR:   A7FRK8
- STRING:   A7FRK8
- GeneID:   5396979
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_0637
- eggNOG:   COG0017
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- ProtClustDB:   PRK03932
- BioCyc:   CBOT441770:CLB_0637-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 53324; Mature: 53324

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITLVKSLYRETEKHMDKEVKINGWVRTVRDSKNFAFVEVNDGSFFKNVQVILESSLEN
CCHHHHHHHHHHHHHHCCCEEEECHHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHH
FKELCKMPISTSVEVEGIVQPTPNAKQPFEIKATRISIEGKSSTDYPLQKKRHTFEYLRT
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
IAHLRPRSNAFSAVFRVRSLAAYAVHKFFQERGFVYTNTPIITGSDCEGAGEMFQLTTMD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCCCCCCEEEEEEEC
LNNIPKTEEGKIDFSKDFFGSPANLTVSGQLSAETFALAFRNVYTFGPTFRAENSNTARH
CCCCCCCCCCCEEECHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCHHH
ASEFWMIEPEMAFAELTDYLDNAEDMVKFVINYVMENAPEEMAFFNSFVDKGLFDRLDNV
HHHEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNSDFKRITYTEAVELLQKSGVKFDYEVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDI
HCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEECCCHHH
KAFYMRLNDDGKTVAAADLLVPGVGEIIGGSQREERLDVLEKRMEELNLNKEDYWWYLEL
HEEEEEECCCCCEEEEHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
RKYGETKHSGYGLGFERILMYITGMTNIRDVIPFPRTPGSAEF
ECCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDITLVKSLYRETEKHMDKEVKINGWVRTVRDSKNFAFVEVNDGSFFKNVQVILESSLEN
CCHHHHHHHHHHHHHHCCCEEEECHHEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHH
FKELCKMPISTSVEVEGIVQPTPNAKQPFEIKATRISIEGKSSTDYPLQKKRHTFEYLRT
HHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHH
IAHLRPRSNAFSAVFRVRSLAAYAVHKFFQERGFVYTNTPIITGSDCEGAGEMFQLTTMD
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCCCCCCEEEEEEEC
LNNIPKTEEGKIDFSKDFFGSPANLTVSGQLSAETFALAFRNVYTFGPTFRAENSNTARH
CCCCCCCCCCCEEECHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEECCCCCCHHH
ASEFWMIEPEMAFAELTDYLDNAEDMVKFVINYVMENAPEEMAFFNSFVDKGLFDRLDNV
HHHEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
VNSDFKRITYTEAVELLQKSGVKFDYEVEWGIDLQTEHERYLTEQIFKKPVFVTDYPKDI
HCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCEEECCCHHH
KAFYMRLNDDGKTVAAADLLVPGVGEIIGGSQREERLDVLEKRMEELNLNKEDYWWYLEL
HEEEEEECCCCCEEEEHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
RKYGETKHSGYGLGFERILMYITGMTNIRDVIPFPRTPGSAEF
ECCCCCCCCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA