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The map label for this gene is ttcA [H]

Identifier: 153935004

GI number: 153935004

Start: 387595

End: 388461

Strand: Direct

Name: ttcA [H]

Synonym: CLC_0399

Alternate gene names: 153935004

Gene position: 387595-388461 (Clockwise)

Preceding gene: 153937779

Following gene: 153935063

Centisome position: 10.31

GC content: 27.68

Gene sequence:

>867_bases
ATGAGTGGTATAGCTGGTAAAGGTTGTGAGGTTTTAGTACCTTTTAATGAAAGAATACCTCTTAAAGATATAGAAAGAAG
TATTGTTAAAAAATATAGAAAGCATATATGGAGTAAATTTGTTAAAGCTATTAAAGAATATAATCTTGTAGAAGACGGTG
ATAAAATAGCCGTGGCAGTTTCTGGTGGAAAAGATAGTATTTTAATGGCGAAATTATTTCAAGAGTTAAAAAAGCATGGT
CAGATAAATTTTGAAATAGAATTTATTTCAATGGACCCTGGTTATCATGAAGATATAAGAAAATTATTAGTAGATAACTG
CAATTATTTAAATATACCTATTAATTTGTTTAATTCTGATATATTTAAAGTTATAGACGACATAGCTAAGGATTACCCCT
GTTATATGTGTGCTAGAATGAGGAGAGGAGCTCTTTATTCTAAAGCCCAGGAATTAGGATGTAATAAATTAGCTTTAGGT
CATCATTTTAATGATGTTATAGAAACTATTTTATTGAACGTGCTTTATGCAGGAAATTTTAAAACTATGTTGCCTAAATT
TAGATCTACAAACTTTGAAGGATTGGAGTTAATAAGGCCATTGTACTATATAGAAGAAGAATATATACAAAAATTCATAC
AAAATAGTGGAATTTGGCCTCTAAACTGTGCTTGTATGGTGGCAGCAGGTAAAATAGGGAATAAAAGACATGAAATAAAA
GATTTAATTAAAGAATTAAAGAAAAACTTTAAGGACGTAGATAAATCTATATTTATGTCATCTAAAAATGTTAATATGGA
AGCTATATTAGGATGGGAAAAGAATAAAGAAAAATATTCTTACTTAGATTTTTATGATGAAGATTAA

Upstream 100 bases:

>100_bases
TTAAAAAAATATAATATAGCTTATTTTTGATTTATTAAAGATCTTTTAACACAAAATAATATAAAAGTGTTATAATATTT
TGCATAAGTGAGGTGAAAAT

Downstream 100 bases:

>100_bases
TATACTTAAATAAGACATAAATAATTAAAAAGATTTCCAAATATTTGTAAATGTAAATTTACTTTAATATTTGGAAATCT
TTTATCTATAAATAGCACAT

Product: PP-loop family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 288; Mature: 287

Protein sequence:

>288_residues
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHG
QINFEIEFISMDPGYHEDIRKLLVDNCNYLNIPINLFNSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALG
HHFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED

Sequences:

>Translated_288_residues
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHG
QINFEIEFISMDPGYHEDIRKLLVDNCNYLNIPINLFNSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALG
HHFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
>Mature_287_residues
SGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAVSGGKDSILMAKLFQELKKHGQ
INFEIEFISMDPGYHEDIRKLLVDNCNYLNIPINLFNSDIFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGH
HFNDVIETILLNVLYAGNFKTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIKD
LIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=241, Percent_Identity=30.7053941908714, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI193211090, Length=264, Percent_Identity=29.5454545454545, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17540090, Length=226, Percent_Identity=26.5486725663717, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24651972, Length=216, Percent_Identity=28.7037037037037, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 33368; Mature: 33237

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAV
CCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SGGKDSILMAKLFQELKKHGQINFEIEFISMDPGYHEDIRKLLVDNCNYLNIPINLFNSD
ECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHH
IFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGHHFNDVIETILLNVLYAGNF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCH
KTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHHHHH
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SGIAGKGCEVLVPFNERIPLKDIERSIVKKYRKHIWSKFVKAIKEYNLVEDGDKIAVAV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEE
SGGKDSILMAKLFQELKKHGQINFEIEFISMDPGYHEDIRKLLVDNCNYLNIPINLFNSD
ECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCEEEEEHHHHHHH
IFKVIDDIAKDYPCYMCARMRRGALYSKAQELGCNKLALGHHFNDVIETILLNVLYAGNF
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCH
KTMLPKFRSTNFEGLELIRPLYYIEEEYIQKFIQNSGIWPLNCACMVAAGKIGNKRHEIK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCCCCHHHHHH
DLIKELKKNFKDVDKSIFMSSKNVNMEAILGWEKNKEKYSYLDFYDED
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA