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The map label for this gene is hom [H]

Identifier: 152977585

GI number: 152977585

Start: 3975906

End: 3977201

Strand: Reverse

Name: hom [H]

Synonym: Bcer98_3923

Alternate gene names: 152977585

Gene position: 3977201-3975906 (Counterclockwise)

Preceding gene: 152977586

Following gene: 152977584

Centisome position: 97.31

GC content: 38.73

Gene sequence:

>1296_bases
ATGAATGAAATTCAGGTAGGGTTATTAGGACTTGGAACAGTCGGAAGCGGTGTGGTTCGTATTATTGAGAACCATCAGGA
TCGATTAATGCACCAAGTAGGTTGCCCAGTGAAAGTAGCAAAAGTACTAGTACAAAATATAGATAAAGAACGTGAGGTCC
AAGTCCCCCCTCATTTATTAACGAAGCGTGCAAATGAAATTATAGATGATCCGAATATTGATGTTGTTATTGAAGTAATG
GGTGGAATAGAAGAAGCAAAAGCTTACATTTTACAAGCTTTAAAGAATGGAAAACATGTTGTTACTGCCAATAAAGATTT
AATGGCATTACATGGGGCAGAGCTTTTAACAGTAGCAAAAGAAAACAGTGCGGATTTATTTTATGAGGCAAGTGTTGCAG
GTGGCATCCCTATTTTACGAAGCATTGTAGAGGGGCTTTCCTCAGATTTGATTACAAAAGTAATGGGGATTGTGAATGGT
ACAACAAATTTTATTTTGACAAAAATGTCTGACGAAGGGAGAGCGTATGACGACGTGTTAAGGGAAGCGCAACAGCTTGG
ATTTGCTGAGGCAGATCCAACATCAGACGTAGAAGGGTTAGATGCGGCAAGAAAGATGACGATTTTAGCAACTCTTGGTT
TCTCTACCAATGTAGAACTTGGAGATGTGAAAGTGAAGGGGATTACTTCTATTACGGAAGAAGATATTGCATATAGCAAA
AGTTTAGGCTATACCATCAAGCTAATCGGACTTGCAAAGCGTGATGGTGACAGGTTAGAAGTAACAGTTGAGCCAACGTT
GCTTTCTAATACACATCCTCTAGCAGCTGTTCAAAATGAATATAATGCTGTATATGTATACGGGGAGGCAGTAGGAGAGA
CGATGTTTTATGGACCGGGTGCTGGAAGTTTACCAACAGCAACAGCGGTTGTTTCTGACCTCGTTGCTGTTATGCAAAAT
ATTCGCCTTGGTGTAACGGGGAATAGTGCAGTTTCTCCACAGTATGAGAAAGTATTAAAAGAGCCTCATGAAATTTTTGT
GAAAAAGTTTTTACGATTGCATGTAAAAGATGAAATTGGTGTATTTGCAAAAATTACATCGCTATTCTCTGAACGAGGTG
TAAGCTTTGAAAAAATTATTCAAATGCCACTTCAGGAGAAAGGAAAAGCTGAAATTGTTATCGTTACTCATCGTGCATCT
CTTGCAGACTATGAATATATTTTACATACATTGGGATCATATGAGGAAGTAGATTGTGTGAAAGCAAACTATCGAATTGA
AGGGGATGCGAAGTAA

Upstream 100 bases:

>100_bases
ACCAATTTTTATTTTTTGAATGTTCTAAATACATTGTTTTTCGGAATTTTAAACTATATAATGACATCTAAATACATTTT
TTAGAGGGGTGAAGAGTGTT

Downstream 100 bases:

>100_bases
TATGGAAAGGCTTCACTGAATATTATGAAAGGCTAGGGGCTGGTTTGAAAGACTTGAGTATTGTAAGTGATACAAAACAG
ATGAATCCAGTTTCCAAATA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNEIQVGLLGLGTVGSGVVRIIENHQDRLMHQVGCPVKVAKVLVQNIDKEREVQVPPHLLTKRANEIIDDPNIDVVIEVM
GGIEEAKAYILQALKNGKHVVTANKDLMALHGAELLTVAKENSADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYDDVLREAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIAYSK
SLGYTIKLIGLAKRDGDRLEVTVEPTLLSNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVSPQYEKVLKEPHEIFVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLQEKGKAEIVIVTHRAS
LADYEYILHTLGSYEEVDCVKANYRIEGDAK

Sequences:

>Translated_431_residues
MNEIQVGLLGLGTVGSGVVRIIENHQDRLMHQVGCPVKVAKVLVQNIDKEREVQVPPHLLTKRANEIIDDPNIDVVIEVM
GGIEEAKAYILQALKNGKHVVTANKDLMALHGAELLTVAKENSADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYDDVLREAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIAYSK
SLGYTIKLIGLAKRDGDRLEVTVEPTLLSNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVSPQYEKVLKEPHEIFVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLQEKGKAEIVIVTHRAS
LADYEYILHTLGSYEEVDCVKANYRIEGDAK
>Mature_431_residues
MNEIQVGLLGLGTVGSGVVRIIENHQDRLMHQVGCPVKVAKVLVQNIDKEREVQVPPHLLTKRANEIIDDPNIDVVIEVM
GGIEEAKAYILQALKNGKHVVTANKDLMALHGAELLTVAKENSADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNG
TTNFILTKMSDEGRAYDDVLREAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIAYSK
SLGYTIKLIGLAKRDGDRLEVTVEPTLLSNTHPLAAVQNEYNAVYVYGEAVGETMFYGPGAGSLPTATAVVSDLVAVMQN
IRLGVTGNSAVSPQYEKVLKEPHEIFVKKFLRLHVKDEIGVFAKITSLFSERGVSFEKIIQMPLQEKGKAEIVIVTHRAS
LADYEYILHTLGSYEEVDCVKANYRIEGDAK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=265, Percent_Identity=27.1698113207547, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790376, Length=369, Percent_Identity=24.1192411924119, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46848; Mature: 46848

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEIQVGLLGLGTVGSGVVRIIENHQDRLMHQVGCPVKVAKVLVQNIDKEREVQVPPHLL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
TKRANEIIDDPNIDVVIEVMGGIEEAKAYILQALKNGKHVVTANKDLMALHGAELLTVAK
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
ENSADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYDDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
REAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIAYSK
HHHHHCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCEECCEEEECCCCCHHHHHHHHH
SLGYTIKLIGLAKRDGDRLEVTVEPTLLSNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEEECCCCEEEEEECCEEECCCCCCCEECCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVSPQYEKVLKEPHEIFVKKFLRLHVKDEIG
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFAKITSLFSERGVSFEKIIQMPLQEKGKAEIVIVTHRASLADYEYILHTLGSYEEVDCV
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEE
KANYRIEGDAK
EECEEECCCCC
>Mature Secondary Structure
MNEIQVGLLGLGTVGSGVVRIIENHQDRLMHQVGCPVKVAKVLVQNIDKEREVQVPPHLL
CCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
TKRANEIIDDPNIDVVIEVMGGIEEAKAYILQALKNGKHVVTANKDLMALHGAELLTVAK
HHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCEEEECCCEEEEEEC
ENSADLFYEASVAGGIPILRSIVEGLSSDLITKVMGIVNGTTNFILTKMSDEGRAYDDVL
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHH
REAQQLGFAEADPTSDVEGLDAARKMTILATLGFSTNVELGDVKVKGITSITEEDIAYSK
HHHHHCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCEECCEEEECCCCCHHHHHHHHH
SLGYTIKLIGLAKRDGDRLEVTVEPTLLSNTHPLAAVQNEYNAVYVYGEAVGETMFYGPG
CCCCEEEEEEEEECCCCEEEEEECCEEECCCCCCCEECCCCCEEEEEECCCCCEEEECCC
AGSLPTATAVVSDLVAVMQNIRLGVTGNSAVSPQYEKVLKEPHEIFVKKFLRLHVKDEIG
CCCCCHHHHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFAKITSLFSERGVSFEKIIQMPLQEKGKAEIVIVTHRASLADYEYILHTLGSYEEVDCV
HHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCEEE
KANYRIEGDAK
EECEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]