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The map label for this gene is pepA [H]

Identifier: 152977214

GI number: 152977214

Start: 3600474

End: 3601955

Strand: Reverse

Name: pepA [H]

Synonym: Bcer98_3532

Alternate gene names: 152977214

Gene position: 3601955-3600474 (Counterclockwise)

Preceding gene: 152977215

Following gene: 152977212

Centisome position: 88.13

GC content: 38.73

Gene sequence:

>1482_bases
ATGTTTCAAGTACAAACTGAATTAGCGAACCATGGAGCAGTCATTGTTGCTTTATTTGAAGAAGAAACGAGCCGTTTTGT
CCAAGAATTAGACAAGGCATTTGAGGGACAATTGCAAGGTTTATTAGATGAAAAAGAACTGAGTACAAAGAAGAAATCTA
TTTCAAAAGTACATAGCTTAGGGAAAACAAATGTAAAACGTTACTACTTTGTTGGCCTTGGAAAAAAAGAAGCATATACA
ACCGAAACATTACGTGCTTCACTGAGTAAAACATTTAAAACATTACAAGCGGAAAAGATACAAGACGCTGCGATCTTGCT
TGACTCATTTGTCACAGAGAAGTTAGATGCAATTGATGTGGCGCATATTGCAGCTGAAGTATATTGCCTTGGCACATACA
GATTACAAACATATAAAACAGATAAAAAAGAACATGTAGAATTAGAAAAACTTGTTGTTATTACAGCAGAGGATGCAAAA
GAAATTGAAGCAGCGTTAACAGTTGGATATGTTCATGGACGTGCTACAAATTCAGCTCGTACGCTTGTAAATATGCCTCC
GAACATGTTAACAGCAACAAAACTGGCAGAATATGCAGTGGAATTAGCTGAAAAATATGATATGGATTATAAAGTATTAG
AGAAAGAGGAAATGGAAGAACTAGGTATGGGTGCTTTACTTGCAGTTAATCAAGGCTCTACAGAACCGCCCAAAATGATT
GCCCTCATTTATAAAGGAAAAGAAGAGTGGAAAGATGTCATTGGGTTGATTGGAAAAGGAATTACATATGATACAGGTGG
TTACTCTTTAAAACCACGCGATGGCATGGTTGGTATGAAGGGTGATATGGGTGGTGCGGCAGCAGTTCTTGGTGCAATGG
AAATTATCGGAGAACTTCGCCCTGAACAAAATGTAATTGCAATTATTCCATCAACAGACAATGTAGTGAGTGGAACTGCA
TTTAAACCAGATGATGTTATCACATCTATGAGCGGGAAAACGATTGAAGTATTAAATACAGATGCAGAAGGTCGCCTTGC
ATTAGCTGATGGAATTACGTATGCGAAGAAGCTTGGTGCAAACTATCTTGTTGATGTGGCAACCTTAACAGGAGGGGTTA
TCGTTGCGCTAGGAAACCATACAACAGGTGCAATGACAAATAATGAAACATTATTTGAACAAGTATTAGAAGCGTCAATG
GAAACAGATGAACGAATTTGGCAATTACCGATTTTTGAACGTGATAAAGAGCGTGTTCGTAACAGTAAATTTGCAGATTT
AAACAACTCACCAGGGCGTGATGGACATGCGGTAATGGCCGGCACATTTCTTGGTGAATTTGCGGAAGACACACCCTGGG
TACATTTAGATATTGCTGGAACTTCTGATACAACGAGTACACATGATTTAGGACCGGCAGGAGCAACAGGTGTAATGGTT
CGTACACTTGCAACACTTGTTGAACGGTTTGGAGAAGAATAA

Upstream 100 bases:

>100_bases
ACCTTTATTGTATATATGAAGCGGAAGAAAAGTTAGAATTATCGCATTTTCGAAAAAATACAGTTATAATAAAAAATAGA
GAAACCAAGGGGGGCTGAAT

Downstream 100 bases:

>100_bases
GAAGCTTAGAAGGGTAGGCGAAATGGCTACCCTTTTTTATCTTGCTATTTTAGGGTAAGCAAGATTGGTGAGGGGCATCA
TTAGTGGTGGGTAAAGAAAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MFQVQTELANHGAVIVALFEEETSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSLGKTNVKRYYFVGLGKKEAYT
TETLRASLSKTFKTLQAEKIQDAAILLDSFVTEKLDAIDVAHIAAEVYCLGTYRLQTYKTDKKEHVELEKLVVITAEDAK
EIEAALTVGYVHGRATNSARTLVNMPPNMLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMI
ALIYKGKEEWKDVIGLIGKGITYDTGGYSLKPRDGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAIIPSTDNVVSGTA
FKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLVDVATLTGGVIVALGNHTTGAMTNNETLFEQVLEASM
ETDERIWQLPIFERDKERVRNSKFADLNNSPGRDGHAVMAGTFLGEFAEDTPWVHLDIAGTSDTTSTHDLGPAGATGVMV
RTLATLVERFGEE

Sequences:

>Translated_493_residues
MFQVQTELANHGAVIVALFEEETSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSLGKTNVKRYYFVGLGKKEAYT
TETLRASLSKTFKTLQAEKIQDAAILLDSFVTEKLDAIDVAHIAAEVYCLGTYRLQTYKTDKKEHVELEKLVVITAEDAK
EIEAALTVGYVHGRATNSARTLVNMPPNMLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMI
ALIYKGKEEWKDVIGLIGKGITYDTGGYSLKPRDGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAIIPSTDNVVSGTA
FKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLVDVATLTGGVIVALGNHTTGAMTNNETLFEQVLEASM
ETDERIWQLPIFERDKERVRNSKFADLNNSPGRDGHAVMAGTFLGEFAEDTPWVHLDIAGTSDTTSTHDLGPAGATGVMV
RTLATLVERFGEE
>Mature_493_residues
MFQVQTELANHGAVIVALFEEETSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSLGKTNVKRYYFVGLGKKEAYT
TETLRASLSKTFKTLQAEKIQDAAILLDSFVTEKLDAIDVAHIAAEVYCLGTYRLQTYKTDKKEHVELEKLVVITAEDAK
EIEAALTVGYVHGRATNSARTLVNMPPNMLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMI
ALIYKGKEEWKDVIGLIGKGITYDTGGYSLKPRDGMVGMKGDMGGAAAVLGAMEIIGELRPEQNVIAIIPSTDNVVSGTA
FKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGANYLVDVATLTGGVIVALGNHTTGAMTNNETLFEQVLEASM
ETDERIWQLPIFERDKERVRNSKFADLNNSPGRDGHAVMAGTFLGEFAEDTPWVHLDIAGTSDTTSTHDLGPAGATGVMV
RTLATLVERFGEE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=490, Percent_Identity=32.6530612244898, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI47155554, Length=365, Percent_Identity=32.0547945205479, Blast_Score=152, Evalue=1e-36,
Organism=Escherichia coli, GI1790710, Length=488, Percent_Identity=36.2704918032787, Blast_Score=284, Evalue=9e-78,
Organism=Escherichia coli, GI87082123, Length=386, Percent_Identity=33.9378238341969, Blast_Score=187, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=297, Percent_Identity=36.026936026936, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=201, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24661038, Length=362, Percent_Identity=33.9779005524862, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21355725, Length=359, Percent_Identity=34.5403899721448, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI20129969, Length=381, Percent_Identity=31.2335958005249, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355645, Length=496, Percent_Identity=28.4274193548387, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI24662223, Length=496, Percent_Identity=28.4274193548387, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI21357381, Length=292, Percent_Identity=35.6164383561644, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI161077148, Length=445, Percent_Identity=27.8651685393258, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20130057, Length=445, Percent_Identity=27.8651685393258, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24662227, Length=378, Percent_Identity=29.8941798941799, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221379063, Length=292, Percent_Identity=35.6164383561644, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI221379062, Length=292, Percent_Identity=35.6164383561644, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19922386, Length=467, Percent_Identity=26.9807280513919, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI20129963, Length=345, Percent_Identity=29.8550724637681, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646701, Length=311, Percent_Identity=28.6173633440514, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646703, Length=311, Percent_Identity=28.6173633440514, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21358201, Length=311, Percent_Identity=28.6173633440514, Blast_Score=106, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53722; Mature: 53722

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVQTELANHGAVIVALFEEETSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSL
CCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GKTNVKRYYFVGLGKKEAYTTETLRASLSKTFKTLQAEKIQDAAILLDSFVTEKLDAIDV
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHIAAEVYCLGTYRLQTYKTDKKEHVELEKLVVITAEDAKEIEAALTVGYVHGRATNSAR
HHHHHEEEEEEEEEEEEECCCCHHHCEEEEEEEEECCCHHHHHHHHEEEEEECCCCCCCC
TLVNMPPNMLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMI
EEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCEE
ALIYKGKEEWKDVIGLIGKGITYDTGGYSLKPRDGMVGMKGDMGGAAAVLGAMEIIGELR
EEEECCHHHHHHHHHHHCCCCEECCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHHCC
PEQNVIAIIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGA
CCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEECCHHHHHHCCC
NYLVDVATLTGGVIVALGNHTTGAMTNNETLFEQVLEASMETDERIWQLPIFERDKERVR
CCEEEHEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHEEECCCCCCHHHHHC
NSKFADLNNSPGRDGHAVMAGTFLGEFAEDTPWVHLDIAGTSDTTSTHDLGPAGATGVMV
CCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHH
RTLATLVERFGEE
HHHHHHHHHHCCC
>Mature Secondary Structure
MFQVQTELANHGAVIVALFEEETSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSL
CCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
GKTNVKRYYFVGLGKKEAYTTETLRASLSKTFKTLQAEKIQDAAILLDSFVTEKLDAIDV
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHIAAEVYCLGTYRLQTYKTDKKEHVELEKLVVITAEDAKEIEAALTVGYVHGRATNSAR
HHHHHEEEEEEEEEEEEECCCCHHHCEEEEEEEEECCCHHHHHHHHEEEEEECCCCCCCC
TLVNMPPNMLTATKLAEYAVELAEKYDMDYKVLEKEEMEELGMGALLAVNQGSTEPPKMI
EEEECCCCHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHCCCCEEEEECCCCCCCCCEE
ALIYKGKEEWKDVIGLIGKGITYDTGGYSLKPRDGMVGMKGDMGGAAAVLGAMEIIGELR
EEEECCHHHHHHHHHHHCCCCEECCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHHCC
PEQNVIAIIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKKLGA
CCCCEEEEECCCCCEECCCCCCCHHHHHCCCCCEEEEEECCCCCCEEEECCHHHHHHCCC
NYLVDVATLTGGVIVALGNHTTGAMTNNETLFEQVLEASMETDERIWQLPIFERDKERVR
CCEEEHEECCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCHHEEECCCCCCHHHHHC
NSKFADLNNSPGRDGHAVMAGTFLGEFAEDTPWVHLDIAGTSDTTSTHDLGPAGATGVMV
CCCCCCCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHH
RTLATLVERFGEE
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA