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The map label for this gene is accB [H]

Identifier: 152976589

GI number: 152976589

Start: 2952287

End: 2952769

Strand: Reverse

Name: accB [H]

Synonym: Bcer98_2878

Alternate gene names: 152976589

Gene position: 2952769-2952287 (Counterclockwise)

Preceding gene: 152976590

Following gene: 152976588

Centisome position: 72.25

GC content: 37.47

Gene sequence:

>483_bases
ATGTTTAAAATTCAGGAAGTTCGTGAATTAATTAAATTAATTGATAGCTCTAATATTGATGAATTTGAATACAAAAAAGA
TGGTACAACAATTAAAATGAAAAAACGCGGTCACGAAGTAGTGGTAGGGCAAGCACCAGCAGTTATGCAAGCAGCGGCTC
CAGCTGTACAAGTAGAAACAACAGCGGCAGCAGCGCAGGTAAAAGTTCCGAAGCAGGAAGAGAAGGAAGTTGTTAAAGAT
GAGAATCTACATAAAATTACATCGCCTATGGTAGGGACATTTTATGCTTCTTCTTCACCTGATGCACCTCCATATGTAAT
GGTTGGAGATCGCGTATCAAAAGATTCTGTTGTATGTATTGTAGAAGCGATGAAGTTATTTAATGAGATTGAGGCAGATG
TAGAGGGCGAAATTGTTGAAATTCTTGTTAATAACGGACAACTTGTTGAATATGGACAACCGCTATTTCTTGTAAAAGCG
TAA

Upstream 100 bases:

>100_bases
TGTTTCCAGTAGAATGCATCGTATTTTTACAGCGAATCGCTTATTTCTCATAGGACGACTGTAAAAACGAGACAAACAAG
AGTATGGGAGTGGGTTTTAT

Downstream 100 bases:

>100_bases
TAAGGGAGTCTTTGTAATGATAAAAAAAGTATTGATAGCCAATCGTGGGGAAATTGCAGTGCGCATTATTCGTGCATGTA
AAGAGATGGATATTGAAACA

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: ADP; phosphate; malonyl-CoA

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGHEVVVGQAPAVMQAAAPAVQVETTAAAAQVKVPKQEEKEVVKD
ENLHKITSPMVGTFYASSSPDAPPYVMVGDRVSKDSVVCIVEAMKLFNEIEADVEGEIVEILVNNGQLVEYGQPLFLVKA

Sequences:

>Translated_160_residues
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGHEVVVGQAPAVMQAAAPAVQVETTAAAAQVKVPKQEEKEVVKD
ENLHKITSPMVGTFYASSSPDAPPYVMVGDRVSKDSVVCIVEAMKLFNEIEADVEGEIVEILVNNGQLVEYGQPLFLVKA
>Mature_160_residues
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGHEVVVGQAPAVMQAAAPAVQVETTAAAAQVKVPKQEEKEVVKD
ENLHKITSPMVGTFYASSSPDAPPYVMVGDRVSKDSVVCIVEAMKLFNEIEADVEGEIVEILVNNGQLVEYGQPLFLVKA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=158, Percent_Identity=37.3417721518987, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: 6.4.1.2

Molecular weight: Translated: 17593; Mature: 17593

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGHEVVVGQAPAVMQAAAPAVQVET
CCCHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCCEEEEECCCHHHHHCCCCEEEEC
TAAAAQVKVPKQEEKEVVKDENLHKITSPMVGTFYASSSPDAPPYVMVGDRVSKDSVVCI
CCCEEEEECCCHHHHHHHCCCCCHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHH
VEAMKLFNEIEADVEGEIVEILVNNGQLVEYGQPLFLVKA
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCEEEEEEC
>Mature Secondary Structure
MFKIQEVRELIKLIDSSNIDEFEYKKDGTTIKMKKRGHEVVVGQAPAVMQAAAPAVQVET
CCCHHHHHHHHHHHCCCCCCCEEECCCCCEEEEECCCCEEEEECCCHHHHHCCCCEEEEC
TAAAAQVKVPKQEEKEVVKDENLHKITSPMVGTFYASSSPDAPPYVMVGDRVSKDSVVCI
CCCEEEEECCCHHHHHHHCCCCCHHHHCCCEEEEEECCCCCCCCEEEECCCCCCCCHHHH
VEAMKLFNEIEADVEGEIVEILVNNGQLVEYGQPLFLVKA
HHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetyl-CoA; HCO3-

Specific reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]