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The map label for this gene is accC1 [H]

Identifier: 152976588

GI number: 152976588

Start: 2950918

End: 2952270

Strand: Reverse

Name: accC1 [H]

Synonym: Bcer98_2877

Alternate gene names: 152976588

Gene position: 2952270-2950918 (Counterclockwise)

Preceding gene: 152976589

Following gene: 152976587

Centisome position: 72.24

GC content: 39.17

Gene sequence:

>1353_bases
ATGATAAAAAAAGTATTGATAGCCAATCGTGGGGAAATTGCAGTGCGCATTATTCGTGCATGTAAAGAGATGGATATTGA
AACAGTTGCTATTTATTCAGAAGCAGATAAAGAATCACTTCATGTACAGATAGCTGATGAGGCATATTGTGTTGGACCAA
CGATGTCAAAAGAAAGTTATTTGAATTTGACAAATATTATTAGTGTTGCTAAGTTAACGGGATGTGATGCAATTCATCCG
GGCTATGGATTTTTAGCTGAAAATGCTGATTTTGCTGAACTATGCCGTGAGTGTAATTTAATCTTTATTGGGCCGAGCCC
AGAAGCGATTTCAAAGATGGGTACAAAAGACGTTGCTCGTGATACAATGAAAGAAGCAGGGGTTCCGATTGTACCGGGTT
CACAAGGTATTATTAAAAACATAGAAGAAGCGATCGAACTTGCAAATGAAATTGGATATCCTGTTATTATTAAAGCGACA
GCTGGTGGTGGAGGAAAAGGAATTCGTGTTGCTCGCCATGAAGAGGAGCTTGTAAAGGGAATTCAAATTACACAGCAAGA
AGCTAGTACCGCTTTTGGAAACCCTGGTGTATACTTAGAAAAGTACGTTGAAGATTTCCGCCATGTTGAGATTCAAATAA
TGGCAGATGCACATGGCAATGCCATTCATTTAGGAGAACGTGATTGTACAATTCAGCGCCGTTTGCAAAAATTGTTAGAA
GAAAGCCCTTCACCTGCTTTGGATGCTGAAATTCGTCAAAAAATGGGTGAAGCGGCAGTGAAAGCGGCAGTAGCAGTTGA
TTATACAGGTGCTGGTACGGTTGAGTTTATTTATGAATATAAAACGAAAAGCTTTTATTTTATGGAAATGAACACACGAA
TTCAAGTGGAACATCCTGTGACTGAAATGGTGACAGGAATGGATTTAATTAAAGAACAAATCCGTGTTGCTTCTGGAGAA
AAGCTATCGTTACAGCAAGAAGAAGTACAATTTAATGGCTGGGCAATTGAATGTCGGATTAATGCGGAAAACCCTGCCAA
AAAATTTATGCCATCCCCAGGTAAAGTTGAAATGTATTTACCGCCAGGTGGGCTTGGTATTCGCGTCGATTCAGCTGTTT
ATCCAGGTTATTCAATTCCACCTTACTATGATTCGATGATTGCAAAGCTAATCGTTCACGGAAAAACTCGCGAAGAAGCA
ATTGCAAAGATGAAGCGAGCGCTTAGTGAGTTTGTCATTGAAGGCGTACATACAACAATCCCGTTCCATTTACAATTGCT
AAATCATCCGGATTTTGTAAAAGGTGAATTTAATACAAAGTTTTTGGAAGAACATGAACTTGTGACGCAGTGA

Upstream 100 bases:

>100_bases
GTAGAGGGCGAAATTGTTGAAATTCTTGTTAATAACGGACAACTTGTTGAATATGGACAACCGCTATTTCTTGTAAAAGC
GTAATAAGGGAGTCTTTGTA

Downstream 100 bases:

>100_bases
TAAAGTGAAACGATTATTGGTGGAACGTTCTGCTCCACTCATGTAGATTTCACGAATTGGGCATTTATAGGTAGGGAACC
TTCTATATGATTTTCTTTCG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A 1; ACC 1 [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTMSKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNIEEAIELANEIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADAHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDAEIRQKMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGMDLIKEQIRVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGLGIRVDSAVYPGYSIPPYYDSMIAKLIVHGKTREEA
IAKMKRALSEFVIEGVHTTIPFHLQLLNHPDFVKGEFNTKFLEEHELVTQ

Sequences:

>Translated_450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTMSKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNIEEAIELANEIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADAHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDAEIRQKMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGMDLIKEQIRVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGLGIRVDSAVYPGYSIPPYYDSMIAKLIVHGKTREEA
IAKMKRALSEFVIEGVHTTIPFHLQLLNHPDFVKGEFNTKFLEEHELVTQ
>Mature_450_residues
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTMSKESYLNLTNIISVAKLTGCDAIHP
GYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVARDTMKEAGVPIVPGSQGIIKNIEEAIELANEIGYPVIIKAT
AGGGGKGIRVARHEEELVKGIQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADAHGNAIHLGERDCTIQRRLQKLLE
ESPSPALDAEIRQKMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPVTEMVTGMDLIKEQIRVASGE
KLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYLPPGGLGIRVDSAVYPGYSIPPYYDSMIAKLIVHGKTREEA
IAKMKRALSEFVIEGVHTTIPFHLQLLNHPDFVKGEFNTKFLEEHELVTQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=445, Percent_Identity=50.1123595505618, Blast_Score=468, Evalue=1e-132,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=51.4672686230248, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=51.4672686230248, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=51.4672686230248, Blast_Score=458, Evalue=1e-129,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=47.8841870824053, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=47.8841870824053, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=47.8841870824053, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI38679960, Length=509, Percent_Identity=31.237721021611, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679974, Length=509, Percent_Identity=31.237721021611, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI38679977, Length=509, Percent_Identity=31.237721021611, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI38679967, Length=509, Percent_Identity=31.237721021611, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI38679971, Length=509, Percent_Identity=31.237721021611, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=31.3725490196078, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=54.8314606741573, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786216, Length=235, Percent_Identity=24.2553191489362, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71987519, Length=446, Percent_Identity=48.8789237668161, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.823927765237, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=46.7706013363029, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=30.5498981670061, Blast_Score=232, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=30.4347826086957, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=30.0395256916996, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI193204318, Length=427, Percent_Identity=22.248243559719, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319685, Length=447, Percent_Identity=45.1901565995526, Blast_Score=401, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319695, Length=449, Percent_Identity=44.3207126948775, Blast_Score=377, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=44.988864142539, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=32.3913043478261, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324343, Length=517, Percent_Identity=30.9477756286267, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=46.5168539325843, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=49.2204899777283, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24651759, Length=407, Percent_Identity=46.1916461916462, Blast_Score=390, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24586458, Length=504, Percent_Identity=30.7539682539683, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI161076409, Length=504, Percent_Identity=30.7539682539683, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI161076407, Length=504, Percent_Identity=30.7539682539683, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24586460, Length=504, Percent_Identity=30.7539682539683, Blast_Score=224, Evalue=1e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49822; Mature: 49822

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTMSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNLTNIISVAKLTGCDAIHPGYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMKEAGVPIVPGSQGIIKNIEEAIELANEIGYPVIIKATAGGGGKGIRVARHEEELVKG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
IQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADAHGNAIHLGERDCTIQRRLQKLLE
HHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDAEIRQKMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPV
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEECCCH
TEMVTGMDLIKEQIRVASGEKLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGLGIRVDSAVYPGYSIPPYYDSMIAKLIVHGKTREEAIAKMKRALSEFVIEGVHTTI
CCCCCEEEECCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLQLLNHPDFVKGEFNTKFLEEHELVTQ
CEEEEEECCCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MIKKVLIANRGEIAVRIIRACKEMDIETVAIYSEADKESLHVQIADEAYCVGPTMSKESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCCEEEECCCCCCHHH
LNLTNIISVAKLTGCDAIHPGYGFLAENADFAELCRECNLIFIGPSPEAISKMGTKDVAR
CCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHCCEEEECCCHHHHHHCCCHHHHH
DTMKEAGVPIVPGSQGIIKNIEEAIELANEIGYPVIIKATAGGGGKGIRVARHEEELVKG
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEECHHHHHHH
IQITQQEASTAFGNPGVYLEKYVEDFRHVEIQIMADAHGNAIHLGERDCTIQRRLQKLLE
HHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHH
ESPSPALDAEIRQKMGEAAVKAAVAVDYTGAGTVEFIYEYKTKSFYFMEMNTRIQVEHPV
CCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCCEEEEEEECCCEEEEEEECCEEEECCCH
TEMVTGMDLIKEQIRVASGEKLSLQQEEVQFNGWAIECRINAENPAKKFMPSPGKVEMYL
HHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCHHHHCCCCCCEEEEE
PPGGLGIRVDSAVYPGYSIPPYYDSMIAKLIVHGKTREEAIAKMKRALSEFVIEGVHTTI
CCCCCEEEECCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PFHLQLLNHPDFVKGEFNTKFLEEHELVTQ
CEEEEEECCCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7592499; 8969508; 9384377 [H]